ArticleNanoscale2018
Measurement of cytokine biomarkers using an aptamer-based affinity graphene nanosensor on a flexible substrate toward wearable applications.
Article in Nanoscale, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
38 citing papers in PubMed.
- Tissue-adhesive hydrogel-MXene biosensor for in situ intraoral TNF-α detection.Science advances · 2026Article
- Noninvasive On-Skin Biosensors for Monitoring Diabetes Mellitus.Nano-micro letters · 2025Review
- Graphene-based wearable biosensors for point-of-care diagnostics: From surface functionalization to biomarker detection.Materials today. Bio · 2025Review
- Modeling reproductive and pregnancy-associated tissues using organ-on-chip platforms: challenges, limitations, and the high throughput data frontier.Frontiers in bioengineering and biotechnology · 2025Review
- Flexible Graphene Field-Effect Transistors and Their Application in Flexible Biomedical Sensing.Nano-micro letters · 2024Review
- Non-invasive ventral cervical magnetoneurography as a proxy of in vivo lipopolysaccharide-induced inflammation.Communications biology · 2024Article
- Nanostructured wearable electrochemical and biosensor towards healthcare management: a review.RSC advances · 2023Review
- Aptamer-functionalized field-effect transistor biosensors for disease diagnosis and environmental monitoring.Exploration (Beijing, China) · 2023Review
- Review on two-dimensional material-based field-effect transistor biosensors: accomplishments, mechanisms, and perspectives.Journal of nanobiotechnology · 2023Review
- Systemic inflammation as a biomarker of seizure propensity and a target for treatment to reduce seizure propensity.Epilepsia open · 2023Review
- Monitoring CdNanoscale advances · 2023Article
- Smart Wearable Systems for Health Monitoring.Sensors (Basel, Switzerland) · 2023Review
- Graphene-Based Field-Effect Transistors in Biosensing and Neural Interfacing Applications: Recent Advances and Prospects.Analytical chemistry · 2023Review
- Advances in flexible graphene field-effect transistors for biomolecule sensing.Frontiers in bioengineering and biotechnology · 2023Review
- In vitro selection of aptamers and their applications.Nature reviews. Methods primers · 2023Article
- Ultrasensitive rapid cytokine sensors based on asymmetric geometry two-dimensional MoSNature communications · 2022Article
- Review
- Aptamers Targeting Cardiac Biomarkers as an Analytical Tool for the Diagnostics of Cardiovascular Diseases: A Review.Biomedicines · 2022Review
- Graphene-Based Biosensors for Molecular Chronic Inflammatory Disease Biomarker Detection.Biosensors · 2022Review
- Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
We present an approach for the label-free detection of cytokine biomarkers using an aptamer-functionalized, graphene-based field effect transistor (GFET) nanosensor on a flexible, SiO2-coated substrate of the polymer polyethylene naphthalate (PEN). The nanosensor conforms to the underlying nonplanar surface and performs GFET-based rapid transduction of the aptamer-biomarker binding, thereby potentially allowing the detection of cytokine biomarkers that are sampled reliably from human bodily fluids (e.g., sweat) in wearable sensing applications. In characterizing the suitability of the nanosensor for wearable applications, we investigate the effects of substrate bending on the equilibrium dissociation constant between the aptamer and the biomarker as well as the graphene transconductance. The utility of the nanosensor is demonstrated by the detection of tumor necrosis factor-α (TNF-α), an inflammatory cytokine biomarker. Experimental results show that the flexible nanosensor can specifically respond to changes in the TNF-α concentration within 5 minutes with a limit of detection as low as 26 pM in a repeatable manner.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.