Evidence map›Paper›PMID 30430872›Full record

ArticleClinical toxicology (Philadelphia, Pa.)2019

Intramuscular cobinamide versus saline for treatment of severe hydrogen sulfide toxicity in swine.

Patrick C Ng, Tara B Hendry-Hofer, Norma Garrett, Matthew Brenner, Sari B Mahon, Joseph K Maddry, Philippe Haouzi, Gerry R Boss, Thomas F Gibbons, Allyson A Araña and 1 more

Registry-linked trialOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical toxicology (Philadelphia, Pa.), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03783091 (A Phase II Double Blind Randomized Controlled Trial of High Dose Vitamin B12 in Septic Shock), which is not on this map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03783091 phase2completednot on this map

A Phase II Double Blind Randomized Controlled Trial of High Dose Vitamin B12 in Septic Shock

TypeinterventionalSponsorMedical College of WisconsinRan2019 to 2023Enrolled20ConditionsSeptic ShockArmsHydroxocobalamin, Placebo
3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Hydrogen Sulfide Toxicity: Mechanism of Action, Clinical Presentation, and Countermeasure Development.Journal of medical toxicology : official journal of the American College of Medical Toxicology · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 8 institutions in 1 country.

Patrick C Nga Rocky Mountain Poison and Drug Center , Denver Health and Hospital Authority , Denver , CO , USA.
Tara B Hendry-Hoferb Department of Emergency Medicine , University of Colorado, School of Medicine , Aurora , CO , USA.
Norma Garrettc Medical Toxicology and the Department of Emergency Medicine , San Antonio Military Medical Center , San Antonio , TX , USA.
Matthew Brennerd Beckman Laser Institute , University of California, Irvine , Irvine , CA , USA.
Sari B Mahond Beckman Laser Institute , University of California, Irvine , Irvine , CA , USA.
Joseph K Maddrye USAF En Route Care Research Center , US Army Institute of Surgical Research , San Antonio , TX , USA.
Philippe Haouzif Division of Pulmonary and Critical Care Medicine , Pennsylvania State University, College of Medicine , Hershey , PA , USA.
Gerry R Bossg Department of Medicine , University of California, San Diego , La Jolla , CA , USA.
Thomas F Gibbonsh Laboratory Services Branch , Clinical Research Division, Wilford Hall Ambulatory Surgical Center , San Antonio , TX , USA.
Allyson A Arañae USAF En Route Care Research Center , US Army Institute of Surgical Research , San Antonio , TX , USA.
Vikhyat S Bebartab Department of Emergency Medicine , University of Colorado, School of Medicine , Aurora , CO , USA.
University of Colorado Denver · USUnited States Army Institute of Surgical Research · USBeckman Laser Institute and Medical Clinic · USPennsylvania State University · USSan Antonio Military Medical Center · USUniversity of California, Irvine · USUniversity of California, San Diego · USWilford Hall Medical Center · US

Funding

Development of the Vitamin B12 Analog cobinamide as a Hydrogen Sulfide AntidoteU01NS087964 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BOSS, GERRY R · 2015 to 2019
$4.3M
NINDS NIH HHS U01 NS087964
6 · The paper itself

Abstract

introductionHydrogen sulfide (H

methodsEleven swine (45-55 kg) were anesthetized, intubated, and instrumented with continuous femoral and pulmonary artery pressure monitoring. After stabilization, anesthesia was adjusted such that animals ventilated spontaneously with a FiO

resultsThe amount of NaHS required to produce apnea or hypotension was not statistically different in both groups (cobinamide: 9.0 mg/kg ±6.1; saline: 5.9 mg/kg ±5.5; mean difference: -3.1, 95% CI: -11.3, 5.0). All of the cobinamide treated animals survived (5/5), none of the control (0/6) animals survived (p < .01). Mean time to return to spontaneous ventilation in the cobinamide treated animals was 3.2 (±1.1) min. Time to return to baseline systolic blood pressure (±5%) in cobinamide-treated animals was 5 min.

conclusionIntramuscular cobinamide was effective in improving survival in this large swine model of severe hydrogen sulfide toxicity.

Indexed as

Administration, IntravenousAnimalsAntidotesApneaCobamidesFemaleHydrogen SulfideHypotensionInjections, IntramuscularKaplan-Meier EstimateSaline SolutionSurvival AnalysisSwineTreatment OutcomeAntidotesCobamidescobinamideHydrogen SulfideSaline SolutionCobinamidehydrogen sulfide toxicityresuscitationswine

Identifiers

PMID30430872
PMCPMC6540978
OpenAlexW2901961148

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.