Evidence map›Paper›PMID 30430783›Full record

ArticleAnnals of laboratory medicine2019

Cluster Containing More Than 20 CD3-Positive Cells in Bone Marrow Biopsy Is a Candidate Prognostic Indicator in Peripheral T-Cell Lymphoma, Not Otherwise Specified.

Hyoeun Shim, Seongsoo Jang, Jooryung Huh, Dok Hyun Yoon, Cheolwon Suh, Chan Jeoung Park

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of laboratory medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 86% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Hyoeun ShimDepartment of Laboratory Medicine, National Cancer Center, Goyang, Korea.
Seongsoo JangDepartment of Laboratory Medicine, University of Ulsan College of Medicine and Asan Medical Center, Seoul, Korea.
Jooryung HuhDepartment of Pathology, University of Ulsan College of Medicine and Asan Medical Center, Seoul, Korea.
Dok Hyun YoonDepartment of Oncology, University of Ulsan College of Medicine and Asan Medical Center, Seoul, Korea.
Cheolwon SuhDepartment of Oncology, University of Ulsan College of Medicine and Asan Medical Center, Seoul, Korea.
Chan Jeoung ParkDepartment of Laboratory Medicine, University of Ulsan College of Medicine and Asan Medical Center, Seoul, Korea. cjpark@amc.seoul.kr.ORCID https://orcid.org/0000-0003-4396-8348
Ulsan College · KRNational Cancer Center · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Assessment of bone marrow (BM) involvement in peripheral T-cell lymphoma, not otherwise specified (PTCL) is straightforward in cases of extensive involvement but difficult in cases of minimal to partial involvement. We evaluated the usefulness of CD3 as an immunohistochemical marker for assessing BM involvement in PTCL patients. BM biopsies of 92 PTCL patients were immunohistochemically stained for CD3, CD4, CD8, CD20, and CD56, and evaluated by two hematopathologists. CD3 positivity was graded according to the proportion of CD3-positive cells and the number of CD3-positive cells in a cluster. These criteria were used to determine the cut-offs at which significant differences in progression-free survival (PFS) and overall survival (OS) were observed. Multivariate analysis controlling the International Prognostic Index (IPI) score and its individual factors revealed that >20 CD3-positive cells in a cluster adversely affected PFS (relative risk [RR], 2.1; 95% confidence interval [CI], 1.0-4.3;

Indexed as

AdolescentAdultAgedAged, 80 and overBone MarrowCD3 ComplexFemaleHumansImmunohistochemistryLymphoma, T-Cell, PeripheralMaleMiddle AgedMultivariate AnalysisPrognosisProgression-Free SurvivalProportional Hazards ModelsCD3 ComplexBone marrow involvementCD3 positivityPeripheral T-cell lymphoma

Identifiers

PMID30430783
PMCPMC6240518
OpenAlexW2901885857

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.