Evidence map›Paper›PMID 30430632›Full record

ArticleInternational journal of geriatric psychiatry2019

The recency ratio is related to CSF amyloid beta 1-42 levels in MCI-AD.

Davide Bruno, Carey E Gleason, Rebecca L Koscik, Nunzio Pomara, Henrik Zetterberg, Kaj Blennow, Sterling C Johnson

Abstract read
In one paragraph

Article in International journal of geriatric psychiatry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.8field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 14 citations in OpenAlex.

  1. Abnormal Forgetting Rate from the Recency Portion of a Word-List in Patients with Subjective Cognitive Decline.Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists · 2026
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  6. The recency ratio assessed by story recall is associated with cerebrospinal fluid levels of neurodegeneration biomarkers.Cortex; a journal devoted to the study of the nervous system and behavior · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 3 countries.

Davide BrunoSchool of Natural Science and Psychology, Liverpool John Moores University, Liverpool, UK.ORCID 0000-0003-1943-9905
Carey E GleasonDivision of Geriatrics, Department of Medicine, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, USA.
Rebecca L KoscikWisconsin Alzheimer's Institute, School of Medicine and Public Health, University of Wisconsin- Madison, Madison, WI, USA.
Nunzio PomaraNathan Kline Institute for Psychiatric Research, Orangeburg, NY, USA.
Henrik ZetterbergClinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden.
Kaj BlennowClinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden.
Sterling C JohnsonDivision of Geriatrics, Department of Medicine, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, USA.
University of Wisconsin–Madison · USSahlgrenska University Hospital · SELiverpool John Moores University · GBNathan Kline Institute for Psychiatric Research · US

Funding

Wisconsin Alzheimer's Disease Research CenterP50AG033514 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI SAGER, MARK · 2009 to 2018
$16.2M
African Americans Fighting Alzheimer’s in Midlife (AA-FAIM)R01AG054059 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI CAREY E GLEASON · 2016 to 2026
$15.3M
NIA NIH HHS P50 AG033514NIA NIH HHS R01 AG054059
6 · The paper itself

Abstract

objectiveAs anti-amyloid therapeutic interventions shift from enrolling patients with Alzheimer's disease (AD) dementia to individuals with pre-clinical disease, the need for sensitive measures that allow for non-invasive, fast, disseminable, and cost-effective identification of preclinical status increases in importance. The recency ratio (Rr) is a memory measure that relies on analysis of serial position performance, which has been found to predict cognitive decline and conversion to early mild cognitive impairment (MCI). The aim of this study was to test Rr's sensitivity to cerebrospinal fluid (CSF) levels of the core AD biomarkers in individuals with MCI-AD and controls.

methodsBaseline data from 126 (110 controls and 16 MCI-AD) participants from the Wisconsin Alzheimer's Disease Research Center were analysed. Partial correlations adjusting for demographics were carried out between CSF measure of amyloid beta (Aβ40, Aβ42, and the 40/42 ratio) and tau (total and phosphorylated), and memory measures (Rr, delayed recall, and total recall) derived from the Rey's Auditory Verbal Learning Test.

resultsResults indicated that Rr was the most sensitive memory score to Aβ42 levels in MCI-AD, while no memory score correlated significantly with any biomarker in controls.

conclusionsThis study shows that Rr is a sensitive cognitive index of underlying amyloid β pathology in MCI-AD.

Indexed as

Memory, Short-TermMental RecallAgedAged, 80 and overAlzheimer DiseaseAmyloid beta-PeptidesBiomarkersCognitive DysfunctionEarly DiagnosisFemaleGenetic Diseases, X-LinkedHumansMaleMiddle AgedPeptide Fragmentstau ProteinsAmyloid beta-Peptidesamyloid beta-protein (1-42)BiomarkersPeptide Fragmentstau ProteinsAlzheimer's diseaseamyloid βA/T/N biomarkersrecency ratio

Identifiers

PMID30430632
PMCPMC6710624
OpenAlexW2901174614

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.