ArticleAlimentary pharmacology & therapeutics2019
Incidence and predictors of new persistent opioid use following inflammatory bowel disease flares treated with oral corticosteroids.
Article in Alimentary pharmacology & therapeutics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06647615 (A Pilot Study to Assess the Safety, Tolerability, and Efficacy of Virtual Reality for the Treatment of Abdominal Pain in Quiescent Crohn's Disease), which is not on this map. Cited by 26 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Pilot Study to Assess the Safety, Tolerability, and Efficacy of Virtual Reality for the Treatment of Abdominal Pain in Quiescent Crohn's Disease
Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.
- The Relationship Between Opioid Use and Healthcare Utilization in Patients With Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis.Inflammatory bowel diseases · 2022Pooled it
- Analgesic Use in Patients with Mild Inflammatory Bowel Disease-A Nationwide Cohort Study Based on Prescription Data.Journal of clinical medicine · 2026Article
- Trends in Use of Prescribed Opioids in Incident and Prevalent Patients With Ulcerative Colitis: A Nationwide Study in Sweden.Inflammatory bowel diseases · 2026Article
- The persistence of chronic opioid use in patients with inflammatory bowel disease-A nationwide cohort study.British journal of clinical pharmacology · 2026Article
- Prevalence of Opioid Use and Associated Healthcare Outcomes in Rome IV Irritable Bowel Syndrome in the United Kingdom.Alimentary pharmacology & therapeutics · 2026Article
- Higher Prescribed Opioid Use Among Adults With Crohn's Disease Than General Population: A Nationwide Cohort Study in Sweden 2006-2021.Alimentary pharmacology & therapeutics · 2025Article
- Article
- Psychiatric Comorbidity Does Not Enhance Prescription Opioid Use in Inflammatory Bowel Disease as It Does in the General Population.Inflammatory bowel diseases · 2025Article
- Impact of chronic opioid use on acute health care utilization in children with IBD and arthritis: a retrospective cohort study.BMC pediatrics · 2024Article
- Opioid use and associated factors in 1676 patients with inflammatory bowel disease: a multicentre quality improvement project.Frontline gastroenterology · 2023Article
- De Novo Ostomy Placement Is Associated with Increased Outpatient Opioid Use In Patients with Inflammatory Bowel Disease.Digestive diseases and sciences · 2022Article
- A Missing Piece of the Puzzle: Patient and Provider Perspectives on Pain Management Needs and Opioid Prescribing in Inflammatory Bowel Disease Care.Crohn's & colitis 360 · 2022Article
- Emerging Comorbidities in Inflammatory Bowel Disease: Eating Disorders, Alcohol and Narcotics Misuse.Journal of clinical medicine · 2021Review
- The Guts of the Opioid Crisis.Physiology (Bethesda, Md.) · 2021Article
- The Reliability of Patient Self-reported Utilization in an Inflammatory Bowel Diseases Learning Health System.Crohn's & colitis 360 · 2021Article
- Variations in Health Care Utilization Patterns Among Inflammatory Bowel Disease Patients at Risk for High Medical Service Utilization Enrolled in High Deductible Health Plans.Inflammatory bowel diseases · 2021Article
- Preoperative opioid use is associated with increased risk of postoperative complications within a colorectal-enhanced recovery protocol.Surgical endoscopy · 2021Article
- Opioid Use Associated With Higher Costs Among Patients With Inflammatory Bowel Disease.Crohn's & colitis 360 · 2021Article
- Trends of 5-Aminosalicylate Medication Use in Patients With Crohn Disease.Inflammatory bowel diseases · 2021Article
- Managing intestinal failure in inflammatory bowel disease - 'when the drugs don't work'.Frontline gastroenterology · 2021Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundOpioids are commonly prescribed to manage pain associated with inflammatory bowel disease (IBD). It is unknown what percentage of patients develop new persistent opioid use following a steroid-treated IBD flare.
aimTo identify the incidence and the predictors of new persistent opioid use following an IBD flare.
methodsWe used a national insurance claim dataset to identify patients with IBD who received an opioid medication around the time of a corticosteroid-treated IBD flare. Patients were stratified as previously opioid naïve, intermittent users, or chronic users. The incidence of persistent opioid use among the opioid-naïve cohort was evaluated along with associated predictors.
resultsWe identified 15 119 IBD patients who received opioids around the time of a flare. 5411 (35.8%) were opioid-naïve patients of which 35.0% developed persistent opioid use after the flare. Factors associated with new persistent opioid use include a history of depression (hazard ratio [HR] 1.29, 95% confidence interval [CI] 1.13-1.47), substance abuse (HR 1.36, 95% CI 1.2-1.54), chronic obstructive pulmonary disease (COPD) (HR 1.17, 95% CI 1.04-1.3), as well as, Crohn's disease (HR 1.26, 95% CI 1.14-1.4) or indeterminate colitis (HR 1.6, 95% CI 1.36-1.88).
conclusionsNew persistent opioid use is common in IBD patients who experience a flare, especially among those with mental health disorders, COPD, and Crohn's disease or indeterminate colitis. These findings can be helpful in risk-stratifying patients when choosing an acute pain therapy and providing counselling before choosing to prescribe opioids to opioid-naïve patients experiencing an IBD flare.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.