Evidence map›Paper›PMID 30430440›Full record

Observational studyCanadian journal of anaesthesia = Journal canadien d'anesthesie2019

An observational study of end-tidal carbon dioxide trends in general anesthesia.

Annemarie Akkermans, Judith A R van Waes, Aleda Thompson, Amy Shanks, Linda M Peelen, Michael F Aziz, Daniel A Biggs, William C Paganelli, Jonathan P Wanderer, Daniel L Helsten and 3 more

Registry-linked trialOpen access · hybridAbstract readMulticenter StudyObservational Study
In one paragraph

Observational study in Canadian journal of anaesthesia = Journal canadien d'anesthesie, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05550181 (Associations of Intraoperative Hypocapnia With Patient Demographics, Ventilation Characteristics and Outcomes--Statistical Analysis Plan for an Individual Patient Data Analysis of PROVHILO and PROBESE), which is not on this map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.6field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05550181 completednot on this mapstarted 2022, after this paper: background citation

Associations of Intraoperative Hypocapnia With Patient Demographics, Ventilation Characteristics and Outcomes--Statistical Analysis Plan for an Individual Patient Data Analysis of PROVHILO and PROBESE

TypeobservationalSponsorNMC Specialty HospitalRan2022 to 2023Enrolled2,793ConditionsMechanical Ventilation Complication, Surgery, Pulmonary Complication, Intraoperative ComplicationsArmsintraoperative mechanical ventilation with hypocapnia (etCO2 < 35 mm Hg)
3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 27 citations in OpenAlex.

  1. Association of intraoperative end-tidal COBritish journal of anaesthesia · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 8 institutions in 3 countries.

Annemarie AkkermansDepartment of Anesthesiology, University Medical Center Utrecht, Heidelberglaan 100, Local mail: Q04.2.313, P.O. Box 85500, 3508 GA, Utrecht, The Netherlands. a.akkermans@umcutrecht.nl.ORCID http://orcid.org/0000-0002-6949-4913
Judith A R van WaesDepartment of Anesthesiology, University Medical Center Utrecht, Heidelberglaan 100, Local mail: Q04.2.313, P.O. Box 85500, 3508 GA, Utrecht, The Netherlands.
Aleda ThompsonDepartment of Anesthesiology, University of Michigan Health System, Ann Arbor, MI, USA.
Amy ShanksDepartment of Anesthesiology, University of Michigan Health System, Ann Arbor, MI, USA.
Linda M PeelenDepartment of Anesthesiology, University Medical Center Utrecht, Heidelberglaan 100, Local mail: Q04.2.313, P.O. Box 85500, 3508 GA, Utrecht, The Netherlands.
Michael F AzizDepartment of Anesthesiology & Perioperative Medicine, Oregon Health & Science University, Portland, OR, USA.
Daniel A BiggsDepartment of Anesthesiology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
William C PaganelliDepartment of Anesthesiology, University of Vermont Larner College of Medicine, Burlington, VT, USA.
Jonathan P WandererDepartment of Anesthesiology, Vanderbilt University Medical Center, Nashville, TN, USA.
Daniel L HelstenDepartment of Anesthesiology, Washington University School of Medicine, St Louis, MO, USA.
Sachin KheterpalDepartment of Anesthesiology, University of Michigan Health System, Ann Arbor, MI, USA.
Wilton A van KleiDepartment of Anesthesiology, University Medical Center Utrecht, Heidelberglaan 100, Local mail: Q04.2.313, P.O. Box 85500, 3508 GA, Utrecht, The Netherlands.
Leif SaagerDepartment of Anesthesiology, University of Michigan Health System, Ann Arbor, MI, USA.
University of Michigan · USHeidelberg University · DEOregon Health & Science University · USUniversity of Oklahoma Health Sciences Center · USUniversity of Vermont · USUtrecht University · NLVanderbilt University Medical Center · USWashington University in St. Louis · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeDespite growing evidence supporting the potential benefits of higher end-tidal carbon dioxide (ETCO

methodsThis retrospective, observational, multicentre study included 317,445 adult patients who received general anesthesia for non-cardiothoracic procedures between January 2008 and September 2016. The primary outcome was a time-weighted average area-under-the-curve (TWA-AUC) for four ETCO

resultsBoth TWA-AUC and median ETCO

conclusionsBetween 2008 and 2016, intraoperative ETCO

Indexed as

Anesthesia, GeneralAdultAgedCapnographyCarbon DioxideDatabases, FactualFemaleHumansLaparoscopyMaleMiddle AgedNeurosurgical ProceduresPulmonary Disease, Chronic ObstructiveRetrospective StudiesRobotic Surgical ProceduresCarbon Dioxide

Identifiers

PMID30430440
PMCPMC6331507
OpenAlexW2901774428

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.