Evidence map›Paper›PMID 30430428›Full record

ReviewInsights into imaging2018

Radiomics and liquid biopsy in oncology: the holons of systems medicine.

Emanuele Neri, Marzia Del Re, Fabiola Paiar, Paola Erba, Paola Cocuzza, Daniele Regge, Romano Danesi

Registry-linked trialAbstract readReview
In one paragraph

Review in Insights into imaging, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06108310 (ATTRACT - ArTificial inTelligence-based RAdiogenomics in Colon Tumors), which is not on this map. Cited by 48 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06108310 unknown statusnot on this mapstarted 2021, after this paper: background citation

ATTRACT - ArTificial inTelligence-based RAdiogenomics in Colon Tumors

TypeobservationalSponsorUniversity of Roma La SapienzaRan2021 to 2025Enrolled500ConditionsColon Cancer Stage II, Colon Cancer Stage III
3 · Its place in the literature

Who cites it

48 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Review
  5. Article
  6. Review
  7. Article
  8. Article
  9. Cholangiocarcinoma: The era of liquid biopsy.World journal of gastroenterology · 2025
    Review
  10. Artificial intelligence for response prediction and personalisation in radiation oncology.Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2025
    Review
  11. Review
  12. Review
  13. Article
  14. Article
  15. Article
  16. Review
  17. Application of radiomics in lung immuno-oncology.Precision radiation oncology · 2023
    Review
  18. Review
  19. Impact of the Rise of Artificial Intelligence in Radiology: What Do Students Think?International journal of environmental research and public health · 2023
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Emanuele NeriDiagnostic and Interventional Radiology, Department of Translational Research, University of Pisa, Pisa, Italy. emanuele.neri@med.unipi.it.
Marzia Del ReClinical Pharmacology and Pharmacogenetics Unit, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.
Fabiola PaiarRadiation Oncology Unit, Department of Translational Research, University of Pisa, Pisa, Italy.
Paola ErbaNuclear Medicine Unit, Department of Translational Research, University of Pisa, Pisa, Italy.
Paola CocuzzaRadiation Oncology Unit, Department of Translational Research, University of Pisa, Pisa, Italy.
Daniele ReggeRadiology Unit, Candiolo Cancer Institute - FPO, IRCCS, Candiolo, Turin, Italy.
Romano DanesiClinical Pharmacology and Pharmacogenetics Unit, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Radiomics is a process of extraction and analysis of quantitative features from diagnostic images. Liquid biopsy is a test done on a sample of blood to look for cancer cells or for pieces of tumourigenic DNA circulating in the blood. Radiomics and liquid biopsy have great potential in oncology, since both are minimally invasive, easy to perform, and can be repeated in patient follow-up visits, enabling the extraction of valuable information regarding tumour type, aggressiveness, progression, and response to treatment. Both methods are in their infancy, with major evidence of application in lung and gastrointestinal cancer, while still undergoing evaluation in other cancer types. In this paper, the main oncologic applications of radiomics and liquid biopsy are reviewed, and a synergistic approach incorporating both tests for cancer diagnosis and follow-up is discussed within the context of systems medicine. TEACHING POINTS: • Radiomics is a process of extraction and analysis of quantitative features from diagnostic images. • Most clinical applications of radiomics are in the field of oncologic imaging. • Radiomics applies to all imaging modalities. • A cluster of radiomic features is a "radiomic signature". • Machine learning may improve the efficacy of radiomics analysis.

Indexed as

Imaging biobanksImaging biomarkersLiquid biopsyPersonalised medicineRadiomics

Identifiers

PMID30430428
PMCPMC6269342

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.