Evidence map›Paper›PMID 30430416›Full record

ArticleHead and neck pathology2019

Immunolocalization of Cancer Stem Cells Marker ALDH1 and its Association with Tumor Budding in Oral Squamous Cell Carcinoma.

Helvécio Marangon Junior, Victória Vasconcellos Moreira Melo, Ângela Braga Caixeta, Giovanna Ribeiro Souto, Paulo Eduardo Alencar Souza, Maria Cássia Ferreira de Aguiar, Martinho Campolina Rebello Horta

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Head and neck pathology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
0.7field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 34 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Predictive value of tumor budding in head and neck squamous cell carcinoma: an update.Virchows Archiv : an international journal of pathology · 2023
    Review
  5. Microvascular density and tumor budding in oral squamous cell carcinoma.Medicina oral, patologia oral y cirugia bucal · 2023
    Article
  6. Review
  7. Review
  8. Article
  9. Tumour budding in solid cancers.Nature reviews. Clinical oncology · 2021
    Review
  10. Article
  11. Article
  12. [Cancer stem cells in oral squamous cell carcinoma. Literature review].Revista cientifica odontologica (Universidad Cientifica del Sur)
    Review
  13. Article
  14. Review
  15. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Helvécio Marangon JuniorOral Pathology Section, School of Dentistry, Pontifical Catholic University of Minas Gerais (PUC Minas), Belo Horizonte, MG, Brazil.
Victória Vasconcellos Moreira MeloOral Pathology Section, School of Dentistry, Pontifical Catholic University of Minas Gerais (PUC Minas), Belo Horizonte, MG, Brazil.
Ângela Braga CaixetaOral Pathology Section, School of Dentistry, Pontifical Catholic University of Minas Gerais (PUC Minas), Belo Horizonte, MG, Brazil.
Giovanna Ribeiro SoutoOral Pathology Section, School of Dentistry, Pontifical Catholic University of Minas Gerais (PUC Minas), Belo Horizonte, MG, Brazil.
Paulo Eduardo Alencar SouzaOral Pathology Section, School of Dentistry, Pontifical Catholic University of Minas Gerais (PUC Minas), Belo Horizonte, MG, Brazil.
Maria Cássia Ferreira de AguiarDepartment of Oral Diagnosis and Pathology, School of Dentistry, Federal University of Minas Gerais (UFMG), Belo Horizonte, MG, Brazil.
Martinho Campolina Rebello HortaOral Pathology Section, School of Dentistry, Pontifical Catholic University of Minas Gerais (PUC Minas), Belo Horizonte, MG, Brazil. martinhohorta@pucminas.br.ORCID http://orcid.org/0000-0003-0192-5614
Pontifícia Universidade Católica de Minas Gerais · BRUniversidade Federal de Minas Gerais · BR

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico CNPq fellowshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior CAPES fellowshipFundação de Amparo à Pesquisa do Estado de Minas Gerais FAPEMIG CDS-APQ-01806/14Fundação de Amparo à Pesquisa do Estado de Minas Gerais FAPEMIG CDS-PPM-00653-16Fundação de Amparo à Pesquisa do Estado de Minas Gerais PROBIC 10499/2016
6 · The paper itself

Abstract

Tumor budding is a prognostic marker for oral squamous cell carcinoma (OSCC) characterized by the presence of isolated or small clusters of neoplastic cells at the tumor invasive front. Aldehyde dehydrogenase-1 (ALDH1) is associated with tumorigenesis, linked to treatment resistance and shown to identify cancer stem cells (CSC)-like cells. This study aimed to evaluate the expression of ALDH1 and its association with tumor budding in OSCC. Immunohistochemistry was employed in 163 OSCC samples to identify pancytokeratin (AE1/AE3) and ALDH1. While pancytokeratin (AE1/AE3) identified squamous tumor buds, the CSC-like cells were identified using ALDH1. A Chi square test was used to evaluate association between ALDH1 expression and tumor budding, while McNemar's test was used to identify differences in ALDH1 expression between the budding area and the area outside the budding. A positive expression of ALDH1 was observed in 47.24% of the samples and in 70% of anatomic locations affected. No association was observed between ALDH1 expression and tumor budding (p > 0.05). In tumors with high-intensity tumor budding, ALDH1 expression was higher in the budding area than in the area outside the budding (p < 0.05). The finding that tumor bud cells in OSCC show phenotypic characteristics of CSC-like cells reinforces the relevance of tumor budding in determining the biological behavior of this malignant neoplasm. Moreover, the presence of CSC-like cells in nearly half of evaluated samples of OSCC and in most of the affected anatomic locations is in accordance with the CSC model of oral carcinogenesis.

Indexed as

AdultAgedAldehyde Dehydrogenase 1 FamilyBiomarkers, TumorFemaleHumansImmunohistochemistryMaleMiddle AgedMouth NeoplasmsNeoplastic Stem CellsSquamous Cell Carcinoma of Head and NeckAldehyde Dehydrogenase 1 FamilyBiomarkers, TumorAldehyde dehydrogenase-1Cancer stem cellsOral cancerSquamous cell carcinomaTumor budding

Identifiers

PMID30430416
PMCPMC6854139
OpenAlexW2901714801

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.