ArticleNeurocritical care2019
Expansion-Prone Hematoma: Defining a Population at High Risk of Hematoma Growth and Poor Outcome.
Article in Neurocritical care, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 3 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Guidelines for Neuroprognostication in Critically Ill Adults with Intracerebral Hemorrhage.Neurocritical care · 2024Guideline
- Effects of subarachnoid extension following intracerebral hemorrhage: A systematic review and meta-analysis.Medicine · 2022Pooled it
- Island Sign Predicts Hematoma Expansion and Poor Outcome After Intracerebral Hemorrhage: A Systematic Review and Meta-Analysis.Frontiers in neurology · 2020Pooled it
- Enhancing hematoma expansion prediction in hypertensive intracerebral hemorrhage based on habitat and perihematomal edema radiomics from non-contrast CT: a dual-center study.Frontiers in neuroscience · 2026Article
- Optimal Timing for Stereotactic Minimally Invasive Surgery in Supratentorial Spontaneous Intracerebral Hemorrhage With Tentorial Herniation: A Retrospective Study.Revista de neurologia · 2025Article
- Heterogeneous hematoma density predicts poor outcome in patients with supratentorial intracerebral hemorrhage after craniotomy.BMC neurology · 2025Article
- CT radiomics combined with clinical and radiological factors predict hematoma expansion in hypertensive intracerebral hemorrhage.European radiology · 2025Article
- Is the frequency of imaging markers still a predictor for revised intracerebral hemorrhage expansion?European stroke journal · 2024Article
- NCCT Markers of Intracerebral Hemorrhage Expansion Using Revised Criteria: An External Validation of Their Predictive Accuracy.AJNR. American journal of neuroradiology · 2023Article
- The "SALPARE study" of spontaneous intracerebral haemorrhage-part 2-early CT predictors of outcome in ICH: keeping it simple.Neurological research and practice · 2023Article
- Article
- A predictive nomogram for intracerebral hematoma expansion based on non-contrast computed tomography and clinical features.Neuroradiology · 2022Article
- Advances in computed tomography-based prognostic methods for intracerebral hemorrhage.Neurosurgical review · 2022Review
- Higher Cerebral Small Vessel Disease Burden in Patients With Small Intracerebral Hemorrhage.Frontiers in neuroscience · 2022Article
- Relationship Between Non-contrast Computed Tomography Imaging Markers and Perihemorrhagic Edema Growth in Intracerebral Hemorrhage.Neurocritical care · 2021Article
- Noncontrast Computed Tomography Markers as Predictors of Revised Hematoma Expansion in Acute Intracerebral Hemorrhage.Journal of the American Heart Association · 2021Article
- Different Effects of Hematoma Expansion on Short-Term Functional Outcome in Basal Ganglia and Thalamic Hemorrhages.BioMed research international · 2021Article
- New Prediction Models of Functional Outcome in Acute Intracerebral Hemorrhage: The dICH Score and uICH Score.Frontiers in neurology · 2021Article
- Comparison of Black Hole Sign, Satellite Sign, and Iodine Sign to Predict Hematoma Expansion in Patients with Spontaneous Intracerebral Hemorrhage.BioMed research international · 2021Article
- Hematoma Ventricle Distance on Computed Tomography Predicts Poor Outcome in Intracerebral Hemorrhage.Frontiers in neuroscience · 2020Article
Corrections and comments
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Authors and funding
13 authors.
Funding
Abstract
backgroundNoncontrast computed tomography (CT) markers are increasingly used for predicting hematoma expansion. The aim of our study was to investigate the predictive value of expansion-prone hematoma in predicting hematoma expansion and outcome in patients with intracerebral hemorrhage (ICH).
methodsBetween July 2011 and January 2017, ICH patients who underwent baseline CT scan within 6 h of symptoms onset and follow-up CT scan were recruited into the study. Expansion-prone hematoma was defined as the presence of one or more of the following imaging markers: blend sign, black hole sign, or island sign. The diagnostic performance of blend sign, black hole sign, island sign, and expansion-prone hematoma in predicting hematoma expansion was assessed. Predictors of hematoma growth and poor outcome were analyzed using multivariable logistical regression analysis.
resultsA total of 282 patients were included in our final analysis. Of 88 patients with early hematoma growth, 69 (78.4%) had expansion-prone hematoma. Expansion-prone hematoma had a higher sensitivity and accuracy for predicting hematoma expansion and poor outcome when compared with any single imaging marker. After adjustment for potential confounders, expansion-prone hematoma independently predicted hematoma expansion (OR 28.33; 95% CI 12.95-61.98) and poor outcome (OR 5.67; 95% CI 2.82-11.40) in multivariable logistic model.
conclusionExpansion-prone hematoma seems to be a better predictor than any single noncontrast CT marker for predicting hematoma expansion and poor outcome. Considering the high risk of hematoma expansion in these patients, expansion-prone hematoma may be a potential therapeutic target for anti-expansion treatment in future clinical studies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.