Evidence map›Paper›PMID 30430320›Full record

ArticleJournal of autism and developmental disorders2019

Prevalence and Predictors of Anxiety Disorders in Adolescent and Adult Males with Autism Spectrum Disorder and Fragile X Syndrome.

Jordan Ezell, Abigail Hogan, Amanda Fairchild, Kimberly Hills, Jessica Klusek, Leonard Abbeduto, Jane Roberts

Abstract read
In one paragraph

Article in Journal of autism and developmental disorders, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed, 1 pooled it
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 1 synthesis or guideline pooled it, 46 citations in OpenAlex.

  1. Pooled it
  2. Profile of Behavioral Comorbidities in Children With Fragile X Syndrome.Journal of autism and developmental disorders · 2026
    Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Distinct social attention profiles in preschoolers with autism contrasted to fragile X syndrome.Autism research : official journal of the International Society for Autism Research · 2023
    Article
  11. Article
  12. Change in Maladaptive Behavior Affects Intergenerational Relationships in Fragile X Syndrome.American journal on intellectual and developmental disabilities · 2022
    Article
  13. Attention/Deficit Hyperactivity Disorder in Adolescent and Young Adult Males With Fragile X Syndrome.American journal on intellectual and developmental disabilities · 2022
    Article
  14. Cluttering in the Speech of Young Men With Fragile X Syndrome.Journal of speech, language, and hearing research : JSLHR · 2022
    Article
  15. Review
  16. Daily Living Skills in Adolescent and Young Adult Males With Fragile X Syndrome.American journal on intellectual and developmental disabilities · 2022
    Article
  17. Anxiety in Angelman Syndrome.American journal on intellectual and developmental disabilities · 2022
    Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Jordan EzellDepartment of Psychology, University of South Carolina, 1512 Pendleton Street, Barnwell College, Suite 220, Columbia, SC, 29208, USA.
Abigail HoganDepartment of Psychology, University of South Carolina, 1512 Pendleton Street, Barnwell College, Suite 220, Columbia, SC, 29208, USA.
Amanda FairchildDepartment of Psychology, University of South Carolina, 1512 Pendleton Street, Barnwell College, Suite 220, Columbia, SC, 29208, USA.
Kimberly HillsDepartment of Psychology, University of South Carolina, 1512 Pendleton Street, Barnwell College, Suite 220, Columbia, SC, 29208, USA.
Jessica KlusekCommunication Sciences and Disorders, Arnold School of Public Health, University of South Carolina, Columbia, SC, USA.
Leonard AbbedutoMIND Institute and Department of Psychiatry and Behavioral Sciences, University of California Davis, Sacramento, CA, USA.
Jane RobertsDepartment of Psychology, University of South Carolina, 1512 Pendleton Street, Barnwell College, Suite 220, Columbia, SC, 29208, USA. jerobert@mailbox.sc.edu.
University of South Carolina · USUniversity of California, Davis · US

Funding

LINGUISTIC COMMUNICATION AND MENTAL RETARDATIONR01HD024356 · NICHD · UNIVERSITY OF WISCONSIN-MADISON · PI ABBEDUTO, LEONARD J. · 1987 to 2022
$9.0M
Rodent Behavior CoreU54HD079125 · NICHD · UNIVERSITY OF CALIFORNIA AT DAVIS · PI ABBEDUTO, LEONARD J. · 2013 to 2019
$8.5M
Emergence, Stability and Predictors of Anxiety in Fragile X SyndromeR01MH107573 · NIMH · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI Abigail Lee Hogan · 2016 to 2026
$6.1M
Supplement to The Emergence and Stability of Autism in Fragile X SyndromeR01MH090194 · NIMH · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI ROBERTS, JANE E · 2011 to 2020
$5.4M
UC Davis Clinical and Translational Science CenterTL1TR000133 · NCATS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI BERGLUND, LARS F · 2012 to 2015
$594k
National Institute of Child Health and Human Development 5R01HD024356-20NCATS NIH HHS TL1 TR000133NICHD NIH HHS R01 HD024356NICHD NIH HHS U54 HD079125NIMH NIH HHS R01 MH090194NIMH NIH HHS R01 MH107573
6 · The paper itself

Abstract

Anxiety disorders affect ~ 15-20% of youths without neurodevelopmental disorders, with persons having autism spectrum disorder (ASD) and fragile X syndrome (FXS) at elevated risk for anxiety disorders. Few studies have compared rates and predictors of anxiety disorders in adolescents with FXS or ASD. This study directly compares rates, predictors, and medication of anxiety disorders between age-matched, male adolescents with FXS (n = 31) or ASD (n = 20). Results indicate that 51.6% of FXS and 50.0% of ASD adolescents met criteria for an anxiety disorder. Cognitive scores and ASD severity did not predict anxiety. Of those with anxiety, ~ 40% of the FXS and 20% of the ASD participants were prescribed medications for anxiety.

Indexed as

AdolescentAdultAnxiety DisordersAutism Spectrum DisorderFragile X SyndromeHumansMalePredictive Value of TestsPrevalenceYoung AdultAnxietyAutism spectrum disorderFragile X syndromeIntellectual disability

Identifiers

PMID30430320
PMCPMC6596989
OpenAlexW2898471971

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.