Evidence map›Paper›PMID 30430209›Full record

Trial reportIntensive care medicine2018

Targeting two different levels of both arterial carbon dioxide and arterial oxygen after cardiac arrest and resuscitation: a randomised pilot trial.

Pekka Jakkula, Matti Reinikainen, Johanna Hästbacka, Pekka Loisa, Marjaana Tiainen, Ville Pettilä, Jussi Toppila, Marika Lähde, Minna Bäcklund, Marjatta Okkonen and 7 more

2 registry-linked trialsOpen access · hybridAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Intensive care medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 90 papers, 13 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
90citing papers in PubMed, 13 pooled it
23.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02698917 nacompletednot on this map

Carbon Dioxide, Oxygen and Mean Arterial Pressure After Cardiac Arrest and Resuscitation - Targeting High vs. Low Normal Values

TypeinterventionalSponsorHelsinki University Central HospitalRan2016 to 2018Enrolled123ConditionsOut-of-Hospital Cardiac ArrestArmsLow normal PaCO2, High normal PaCO2, Low normal PaO2, High normal PaO2, Low normal MAP
NCT04608825 completednot on this mapstarted 2020, after this paper: background citation

Intensive Care Unit Management After Cardiac ARrest in Russia. - a Retrospective Observational Multi-center Cohort Study

TypeobservationalSponsorRussian Federation of Anesthesiologists and ReanimatologistsRan2020 to 2023Enrolled500ConditionsPost Cardiac Arrest Syndrome
3 · Its place in the literature

Who cites it

90 citing papers in PubMed, 13 syntheses or guidelines pooled it, 216 citations in OpenAlex.

  1. Pooled it
  2. Guideline
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  4. Conservative versus liberal oxygen therapy in mechanically ventilated patients: A systematic review with meta-analysis.Canadian journal of respiratory therapy : CJRT = Revue canadienne de la therapie respiratoire : RCTR · 2025
    Pooled it
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  10. Guideline
  11. Guideline
  12. Pooled it
  13. Pooled it
  14. Trial
  15. Trial
  16. Trial
  17. Review
  18. Review
  19. Article
  20. Article

30 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

17 authors at 2 institutions in 2 countries.

Pekka JakkulaDepartment of Anaesthesiology, Intensive Care and Pain Medicine, University of Helsinki and Helsinki University Hospital, Helsinki, Finland. pekka.jakkula@hus.fi.ORCID http://orcid.org/0000-0002-7858-1365
Matti ReinikainenDepartment of Intensive Care, North Karelia Central Hospital, Joensuu, Finland.
Johanna HästbackaDepartment of Anaesthesiology, Intensive Care and Pain Medicine, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Pekka LoisaDepartment of Intensive Care, Päijät-Häme Central Hospital, Lahti, Finland.
Marjaana TiainenDepartment of Neurology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Ville PettiläDepartment of Anaesthesiology, Intensive Care and Pain Medicine, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Jussi ToppilaClinical Neurophysiology, HUS Medical Imaging Center, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Marika LähdeDepartment of Anaesthesia and Intensive Care, Päijät-Häme Central Hospital, Lahti, Finland.
Minna BäcklundDepartment of Anaesthesiology, Intensive Care and Pain Medicine, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Marjatta OkkonenDepartment of Anaesthesiology, Intensive Care and Pain Medicine, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Stepani BendelDepartment of Intensive Care, Kuopio University Hospital, Kuopio, Finland.
Thomas BirkelundAarhus University Hospital, Aarhus, Denmark.
Anni PulkkinenDepartment of Anaesthesia and Intensive Care, Central Finland Central Hospital, Jyväskylä, Finland.
Jonna HeinonenDepartment of Anaesthesiology, Intensive Care and Pain Medicine, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Tuukka TikkaDepartment of Anaesthesiology, Intensive Care and Pain Medicine, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Markus B SkrifvarsDepartment of Anaesthesiology, Intensive Care and Pain Medicine, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
COMACARE study group
University of Helsinki · FIAarhus University Hospital · DK

Funding

Finska Läkaresällskapet -Helsingin ja Uudenmaan Sairaanhoitopiiri VTR-TYH2016132Helsingin Yliopisto H3702Helsingin Yliopisto WBS 73702705Instrumentariumin Tiedesäätiö -Laerdal Foundation for Acute Medicine -Medicinska Understödsföreningen Liv och Hälsa -Orionin Tutkimussäätiö -Stiftelsen Dorothea Olivia, Karl Walter och Jarl Walter Perkléns Minne -Suomen Anestesiologiyhdistys -Svenska Kulturfonden -
6 · The paper itself

Abstract

purposeWe assessed the effects of targeting low-normal or high-normal arterial carbon dioxide tension (PaCO

methodsUsing a 2

resultsIn total 120 patients were included in the analyses. There was a clear separation in PaCO

conclusionsBoth high-normal PaCO REGISTRATION: ClinicalTrials.gov, NCT02698917. Registered on January 26, 2016.

Indexed as

AdultAgedArterial PressureBlood Gas AnalysisCarbon DioxideCardiopulmonary ResuscitationCritical CareFemaleHumansHypercapniaHyperoxiaHypocapniaHypoxia-Ischemia, BrainMaleMiddle AgedOut-of-Hospital Cardiac ArrestCarbon DioxideOxygenPhosphopyruvate HydrataseCarbon dioxideCardiac arrestHypoxic ischemic encephalopathyIntensive careMechanical ventilationNeuron-specific enolase (NSE)Oxygen

Identifiers

PMID30430209
PMCPMC6280824
OpenAlexW2901800937

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.