Evidence map›Paper›PMID 30430161›Full record

ArticleChemical communications (Cambridge, England)2018

Desferrioxamine:gallium-pluronic micelles increase outer membrane permeability and potentiate antibiotic activity against Pseudomonas aeruginosa.

Max Purro, Jing Qiao, Zhi Liu, Morgan Ashcraft, May P Xiong

Open access · greenAbstract read
In one paragraph

Article in Chemical communications (Cambridge, England), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.4field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Max PurroDepartment of Pharmaceutical and Biomedical Sciences, College of Pharmacy, University of Georgia, Athens, GA, USA. mpxiong@uga.edu.
Jing Qiao
Zhi Liu
Morgan Ashcraft
May P Xiong
University of Georgia · USUniversity of Wisconsin–Madison · US

Funding

LipoGels for Chelation of Transfusional Iron-OverloadR01DK099596 · NIDDK · UNIVERSITY OF WISCONSIN-MADISON · PI XIONG, M PANG · 2013 to 2017
$1.5M
NIDDK NIH HHS R01 DK099596
6 · The paper itself

Abstract

The outer membrane of Pseudomonas aeruginosa functions primarily as a permeability barrier and imparts a broad spectrum of intrinsic antibiotic resistance. Herein, we describe the synthesis, characterization, and antimicrobial evaluation of a targeted polymeric micelle that specifically permeabilizes the outer membrane and potentiates antibiotic activity against P. aeruginosa.

Indexed as

Drug SynergismMicellesAnti-Bacterial AgentsCell Membrane PermeabilityDeferoxamineDrug Resistance, BacterialErythromycinEscherichia coliGalliumHeLa CellsHumansMicrobial Sensitivity TestsPoloxamerPseudomonas aeruginosaRifampinSurface-Active AgentsAnti-Bacterial AgentsDeferoxamineErythromycinGalliumMicellesPoloxamerRifampinSurface-Active AgentsVancomycin

Identifiers

PMID30430161
PMCPMC6345168
OpenAlexW2899787598

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.