ArticleMedChemComm2018
Synthesis of dihydronaphthalene analogues inspired by combretastatin A-4 and their biological evaluation as anticancer agents.
Abstract read
In one paragraph
Article in MedChemComm, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.4field-weighted citation impact, top 21% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 22 citations in OpenAlex.
- Targeting Tumor-Associated Hypoxia with Bioreductively Activatable Prodrug Conjugates Derived from Dihydronaphthalene, Benzosuberene, and Indole-based Inhibitors of Tubulin Polymerization.RSC medicinal chemistry · 2025Article
- Benzosuberene and Tetracyclic Analogues as Colchicine Site Inhibitors of Tubulin Polymerization.ACS medicinal chemistry letters · 2025Article
- Drug-Linker Constructs Bearing Unique Dual-Mechanism Tubulin Binding Payloads Tethered through Cleavable and Non-Cleavable Linkers.Tetrahedron · 2025Article
- Application of Chlorosulfonyl Isocyanate (CSI) in the Synthesis of Fused Tetracyclic Ketone Ring Systems.The Journal of organic chemistry · 2024Article
- Chemical synthesis and application of aryldihydronaphthalene derivatives.RSC advances · 2024Review
- Medicinal chemistry perspective on the structure-activity relationship of stilbene derivatives.RSC advances · 2024Review
- Synthesis and biological evaluation of structurally diverse 6-aryl-3-aroyl-indole analogues as inhibitors of tubulin polymerization.European journal of medicinal chemistry · 2024Article
- Structure Guided Design, Synthesis, and Biological Evaluation of Oxetane-Containing Indole Analogues.Bioorganic & medicinal chemistry · 2023Article
- Article
- 3-D Super-Resolution Ultrasound Imaging for Monitoring Early Changes in Breast Cancer after Treatment with a Vascular-Disrupting Agent.IEEE International Ultrasonics Symposium : [proceedings]. IEEE International Ultrasonics Symposium · 2021Article
- Non-Invasive Evaluation of Acute Effects of Tubulin Binding Agents: A Review of Imaging Vascular Disruption in Tumors.Molecules (Basel, Switzerland) · 2021Review
- More Than Resveratrol: New Insights into Stilbene-Based Compounds.Biomolecules · 2020Review
- Colchicine-Binding Site Inhibitors from Chemistry to Clinic: A Review.Pharmaceuticals (Basel, Switzerland) · 2020Review
- Synthesis and biological evaluation of structurally diverse α-conformationally restricted chalcones and related analogues.MedChemComm · 2019Article
- Structure Guided Design, Synthesis, and Biological Evaluation of Novel Benzosuberene Analogues as Inhibitors of Tubulin Polymerization.Journal of medicinal chemistry · 2019Article
- Efficient Synthetic Methodology for the Construction of Dihydronaphthalene and Benzosuberene Molecular Frameworks.Tetrahedron letters · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 3 institutions in 1 country.
Casey J MaguireDepartment of Chemistry and Biochemistry , Baylor University , One Bear Place #97348 , Waco , TX 76798-7348 , USA . Email: Kevin_Pinney@baylor.edu ; Tel: +(254) 710 4117.
Zhi ChenDepartment of Chemistry and Biochemistry , Baylor University , One Bear Place #97348 , Waco , TX 76798-7348 , USA . Email: Kevin_Pinney@baylor.edu ; Tel: +(254) 710 4117.
Vani P MocharlaDepartment of Chemistry and Biochemistry , Baylor University , One Bear Place #97348 , Waco , TX 76798-7348 , USA . Email: Kevin_Pinney@baylor.edu ; Tel: +(254) 710 4117.
Madhavi SriramDepartment of Chemistry and Biochemistry , Baylor University , One Bear Place #97348 , Waco , TX 76798-7348 , USA . Email: Kevin_Pinney@baylor.edu ; Tel: +(254) 710 4117.
Tracy E StreckerDepartment of Chemistry and Biochemistry , Baylor University , One Bear Place #97348 , Waco , TX 76798-7348 , USA . Email: Kevin_Pinney@baylor.edu ; Tel: +(254) 710 4117.
Ernest HamelScreening Technologies Branch , Developmental Therapeutics Program , Division of Cancer Treatment and Diagnosis , National Cancer Institute , Frederick National Laboratory for Cancer Research , National Institutes of Health , Frederick , MD 21702 , USA.
Heling ZhouDepartment of Radiology , The University of Texas Southwestern Medical Center , 5323 Harry Hines Boulevard , Dallas , TX 75390-9058 , USA.
Ramona LopezDepartment of Radiology , The University of Texas Southwestern Medical Center , 5323 Harry Hines Boulevard , Dallas , TX 75390-9058 , USA.
Yifan WangDepartment of Chemistry and Biochemistry , Baylor University , One Bear Place #97348 , Waco , TX 76798-7348 , USA . Email: Kevin_Pinney@baylor.edu ; Tel: +(254) 710 4117.
Ralph P MasonDepartment of Radiology , The University of Texas Southwestern Medical Center , 5323 Harry Hines Boulevard , Dallas , TX 75390-9058 , USA.ORCID 0000-0001-7517-3721
David J ChaplinDepartment of Chemistry and Biochemistry , Baylor University , One Bear Place #97348 , Waco , TX 76798-7348 , USA . Email: Kevin_Pinney@baylor.edu ; Tel: +(254) 710 4117.
Mary Lynn TrawickDepartment of Chemistry and Biochemistry , Baylor University , One Bear Place #97348 , Waco , TX 76798-7348 , USA . Email: Kevin_Pinney@baylor.edu ; Tel: +(254) 710 4117.ORCID 0000-0002-3734-7329
Kevin G PinneyDepartment of Chemistry and Biochemistry , Baylor University , One Bear Place #97348 , Waco , TX 76798-7348 , USA . Email: Kevin_Pinney@baylor.edu ; Tel: +(254) 710 4117.ORCID 0000-0003-1262-8631
Baylor University · USThe University of Texas Southwestern Medical Center · USNational Institutes of Health · US
Funding
UT Southwestern Medical Center Simmons Comprehensive Cancer CenterP30CA142543 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI MELANIE H. COBB · 2010 to 2026
$53.7MUT Southwestern Small Animal Imaging ResourceU24CA126608 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI MASON, RALPH P., SHERRY, DEAN · 2007 to 2011
$2.3MChemotherapeutic Agents with Enhanced Selectivity for the Tumor MicroenvironmentR01CA140674 · NCI · BAYLOR UNIVERSITY · PI PINNEY, KEVIN G., TRAWICK, MARY LYNN · 2010 to 2014
$1.4MSmall Animal Bioluminescence and Fluorescence Imaging System (with 3D capability)S10RR024757 · NCRR · UT SOUTHWESTERN MEDICAL CENTER · PI MASON, RALPH P. · 2007 to 2007
$335kZEISS PALM MicroBeam IV module Rel 4.2S10RR031859 · NCRR · OHIO STATE UNIVERSITY · PI ROY, SASHWATI · 2011 to 2011
$297kNCI NIH HHS P30 CA142543NCI NIH HHS R01 CA140674NCI NIH HHS U24 CA126608NCRR NIH HHS S10 RR024757NCRR NIH HHS S10 RR031859
Abstract
The natural products colchicine and combretastatin A-4 (
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.