ReviewJournal of oral & maxillofacial research
Dental Implant Placement in Patients on Bisphosphonate Therapy: a Systematic Review.
Review in Journal of oral & maxillofacial research. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Dental implant failure and retrieval techniques; a scoping review.Frontiers in oral health · 2025Pooled it
- Do dental implants placed in patients with osteoporosis have higher risks of failure and marginal bone loss compared to those in healthy patients? A systematic review with meta-analysis.Clinical oral investigations · 2023Pooled it
- An Evaluation of the Peri-Implant Tissue in Patients Starting Antiresorptive Agent Treatment After Implant Placement: A Nested Case-Control Study.Medicina (Kaunas, Lithuania) · 2025Article
- Histological and morphometrical evaluation of non-critical bone defects after treatment with biomaterial and bisphosphonates.Medicina oral, patologia oral y cirugia bucal · 2025Article
- Optimization of Peri-Implant Bone Repair in Estrogen-Deficient Rats on a Cafeteria Diet: The Combined Effects of Systemic Risedronate and Genistein-Functionalized Implants.Materials (Basel, Switzerland) · 2025Article
- Treatment strategies for dental implant removal: A literature review.The Japanese dental science review · 2024Review
- A study of peri-implant tissue clinical parameters in patients starting anti-osteoporosis medication after existing implant function: a prospective cohort study.International journal of implant dentistry · 2024Article
- Review
- Expert consensus on endodontic therapy for patients with systemic conditions.International journal of oral science · 2024Review
- Review
- Bisphosphonates and Their Connection to Dental Procedures: Exploring Bisphosphonate-Related Osteonecrosis of the Jaws.Cancers · 2023Review
- Review
- A clinical retrospective study of implant as a risk factor for medication-related osteonecrosis of the jaw: surgery vs loading?Maxillofacial plastic and reconstructive surgery · 2023Article
- Evaluation of health screening data for factors associated with peri-implant bone loss.Journal of periodontal & implant science · 2022Article
- Antiresorptive therapy and dental implant survival: an up to 20-year retrospective cohort study in women.Clinical oral investigations · 2022Article
- Customized Titanium Mesh for Guided Bone Regeneration in the Posterior Mandible in a Patient Previously Treated with Bisphosphonates.Case reports in dentistry · 2022Article
- Inhibitory Effects of Alendronate on Adhesion and Viability of Preosteoblast Cells on Titanium Discs.European journal of dentistry · 2021Article
- Histomorphometric Evaluation of Peri-Implant Bone Response to Intravenous Administration of Zoledronate (ZometaMaterials (Basel, Switzerland) · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThe review aims to study dental implant placement purposefulness for patients who have been treated or are on treatment with bisphosphonate medication. MATERIAL AND
methodsStructured search strategy was applied on electronic databases: MEDLINE, PubMed, PubMed Central and ResearchGate. Scientific publications in English between 2006 and 2017 were identified in accordance with inclusion, exclusion criteria. Publication screening, data extraction, and quality assessment were performed. Outcome measures included implant failure or implant-related osteonecrosis of the jaw.
resultsIn total, 32 literature sources were reviewed, and 9 of the most relevant articles that are suitable to the criteria were selected. Heterogeneity between the studies was found and no meta-analysis could be done. Five studies analysed intraoral bisphosphonate medication in relation with implant placement, three studies investigated intravenous bisphosphonate medication in relation with implant placement and one study evaluated both types of medication given in relation with implant placement. Patients with intraoral therapy appeared to have a better implant survival (5 implants failed out of 423) rate at 98.8% vs. patients treated intravenously (6 implants failed out of 68) at 91%; the control group compared with intraoral bisphosphonate group appeared with 97% success implant survival rate (27 implants failed out of 842), showing no significant difference in terms of success in implant placement.
conclusionsPatients treated with intravenous bisphosphonates seemed to have a higher chance of developing implant-related osteonecrosis of the jaw. The intraorally treated patient group appeared to have more successful results. Implant placement in patients treated intraorally could be considered safe with precautions.
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