Evidence map›Paper›PMID 30429891›Full record

ArticleTheranostics2018

Overexpression of HOXC10 promotes angiogenesis in human glioma via interaction with PRMT5 and upregulation of VEGFA expression.

Zhanyao Tan, Kun Chen, Wenjiao Wu, Yanqing Zhou, Jinrong Zhu, Geyan Wu, Lixue Cao, Xin Zhang, Hongyu Guan, Yi Yang and 2 more

Open access · goldAbstract read
In one paragraph

Article in Theranostics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
58citing papers in PubMed, 1 pooled it
3.9field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

58 citing papers in PubMed, 1 synthesis or guideline pooled it, 82 citations in OpenAlex.

  1. Pooled it
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  15. mInternational journal of oncology · 2024
    Article
  16. Article
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  18. Article
  19. Article
  20. Long non-coding RNAAmerican journal of cancer research · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 1 country.

Zhanyao TanProgram of cancer research, Affiliated Guangzhou Women and Children's Hospital, Department of Biochemistry, Zhongshan School of Medicine, Sun Yat-sen University, China.
Kun ChenDepartment of Neurosurgery, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China.
Wenjiao WuDepartment of Neurosurgery, the First Affiliated Hospital of Jinan University, Guangzhou, Guangdong, China.
Yanqing ZhouNeurosurgical Research Institute, the First Affiliated Hospital of Guangdong Pharmaceutics University, Guangzhou, Guangdong, China.
Jinrong ZhuProgram of cancer research, Affiliated Guangzhou Women and Children's Hospital, Department of Biochemistry, Zhongshan School of Medicine, Sun Yat-sen University, China.
Geyan WuProgram of cancer research, Affiliated Guangzhou Women and Children's Hospital, Department of Biochemistry, Zhongshan School of Medicine, Sun Yat-sen University, China.
Lixue CaoProgram of cancer research, Affiliated Guangzhou Women and Children's Hospital, Department of Biochemistry, Zhongshan School of Medicine, Sun Yat-sen University, China.
Xin ZhangClinical Experimental Center, Department of Pathology (Clinical Biobanks), Jiangmen Central Hospital, Affiliated Jiangmen Hospital of Sun Yat-sen University, Jiangmen, Guangdong, China.
Hongyu GuanDepartment of Endocrinology and Diabetes Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China.
Yi YangDepartment of Pharmacology, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, Guangdong, China.
Wei ZhangNeurosurgical Research Institute, the First Affiliated Hospital of Guangdong Pharmaceutics University, Guangzhou, Guangdong, China.
Jun LiProgram of cancer research, Affiliated Guangzhou Women and Children's Hospital, Department of Biochemistry, Zhongshan School of Medicine, Sun Yat-sen University, China.
Sun Yat-sen University · CNThe First Affiliated Hospital, Sun Yat-sen University · CNFirst Affiliated Hospital of Jinan University · CNJiangmen Central Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

High levels of angiogenesis are associated with poor prognosis in patients with gliomas. However, the molecular mechanisms underlying tumor angiogenesis remain unclear.

Indexed as

Neovascularization, PathologicUp-RegulationAngiogenesis InhibitorsAnimalsBevacizumabCell MovementCell ProliferationChick EmbryoChorioallantoic MembraneChromatin ImmunoprecipitationGene ExpressionGene Regulatory NetworksGliomaHeterograftsHistone-Lysine N-MethyltransferaseHomeodomain ProteinsAngiogenesis InhibitorsBevacizumabHistone-Lysine N-MethyltransferaseHomeodomain ProteinsHOXC10 protein, humanIntracellular Signaling Peptides and ProteinsPRMT5 protein, humanProtein-Arginine N-MethyltransferasesVascular Endothelial Growth Factor AVEGFA protein, humanWDR5 protein, humanangiogenesisbevacizumabgliomaHOXC10VEGFA

Identifiers

PMID30429891
PMCPMC6217061
OpenAlexW2898597108

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.