Evidence map›Paper›PMID 30429889›Full record

ArticleTheranostics2018

Theranostic pretargeted radioimmunotherapy of internalizing solid tumor antigens in human tumor xenografts in mice: Curative treatment of HER2-positive breast carcinoma.

Sarah M Cheal, Hong Xu, Hong-Fen Guo, Mitesh Patel, Blesida Punzalan, Edward K Fung, Sang-Gyu Lee, Meghan Bell, Manisha Singh, Achim A Jungbluth and 4 more

Open access · goldAbstract read
In one paragraph

Article in Theranostics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
4.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 38 citations in OpenAlex.

  1. Review
  2. PretargetedTheranostics · 2026
    Article
  3. Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2025
    Article
  4. Article
  5. Article
  6. Review
  7. [European journal of nuclear medicine and molecular imaging · 2024
    Article
  8. Review
  9. Pretargeted Radioimmunotherapy of Ovarian Cancer withJournal of nuclear medicine : official publication, Society of Nuclear Medicine · 2023
    Article
  10. Efficacy of HER2-Targeted IntraperitonealJournal of nuclear medicine : official publication, Society of Nuclear Medicine · 2023
    Article
  11. Optical image-guided therapy of pancreatic cancer with an ultra-small bispecific protein.European journal of nuclear medicine and molecular imaging · 2023
    Article
  12. Clearing and Masking Agents in Pretargeting Strategies.Pharmaceuticals (Basel, Switzerland) · 2023
    Review
  13. Article
  14. Pretargeting: A Path Forward for Radioimmunotherapy.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2022
    Review
  15. Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2022
    Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 1 institution in 1 country.

Sarah M ChealMolecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Hong XuDepartment of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Hong-Fen GuoDepartment of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Mitesh PatelDepartment of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Blesida PunzalanMolecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Edward K FungDepartment of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Sang-Gyu LeeDepartment of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Meghan BellDepartment of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Manisha SinghMolecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Achim A JungbluthDepartment of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Pat B ZanzonicoDepartment of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Alessandra PiersigilliTri-Institutional Laboratory of Comparative Pathology, Memorial Sloan Kettering Cancer Center, Weill Cornell Medicine, and The Rockefeller University, New York, NY 10065, USA.
Steven M LarsonMolecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Nai-Kong V CheungMolecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Memorial Sloan Kettering Cancer Center · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4M
NCI NIH HHS P30 CA008748
6 · The paper itself

Abstract

In recent reports, we have shown that optimized pretargeted radioimmunotherapy (PRIT) based on molecularly engineered antibody conjugates and

Indexed as

AnimalsAntibodies, NeoplasmAntigens, NeoplasmBreast NeoplasmsDisease Models, AnimalErb-b2 Receptor Tyrosine KinasesHeterograftsHumansMiceMice, NudeMolecular Targeted TherapyNeoplasm TransplantationOctreotideOrganometallic CompoundsRadioimmunotherapyTheranostic NanomedicineAntibodies, NeoplasmAntigens, NeoplasmERBB2 protein, humanErb-b2 Receptor Tyrosine Kinaseslutetium Lu 177 dotatateOctreotideOrganometallic Compoundsbispecific antibodiesHER2lutetium-177multistep targetingpretargetingradioimmunotherapy

Identifiers

PMID30429889
PMCPMC6217068
OpenAlexW2898436197

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.