ArticleNature2018
Improved reference genome of Aedes aegypti informs arbovirus vector control.
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Article in Nature, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 341 papers.
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341citing papers in PubMed
69.8field-weighted citation impact, top 1% of its field
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Who cites it
341 citing papers in PubMed, 671 citations in OpenAlex.
- Article
- Transcriptional responses of Aedes aegypti chemosensory tissues in response to volatile DEET and citronella oil.Insect molecular biology · 2026Article
- Introgression Shapes Genetic Variation Associated With Humid Environments in Aedes aegypti Mosquitoes From Saudi Arabia.Molecular ecology · 2026Article
- Convergent evolutionary loss of chemosensory and blood-feeding pathways in non-blood-feeding mosquitoes.bioRxiv : the preprint server for biology · 2026Article
- Split suppression gene drives reveal a design tradeoff between inheritance and reproductive load inbioRxiv : the preprint server for biology · 2026Article
- Article
- Resistance to pyrethroids in Aedes aegypti: Insights into transcriptomic response to different insecticide concentrations.PLoS neglected tropical diseases · 2026Article
- Vector competence acrossJournal of virology · 2026Review
- Gustatory function of Aedes aegypti opsins and TRPA1 in avoiding a natural insect repellent.Current biology : CB · 2026Article
- Odorant receptor coexpression and multi-expression in the dengue mosquito.Nature communications · 2026Article
- Advances in mosquito olfaction: Genetic, genomic, and behavioral approaches in Aedes aegypti.Current opinion in neurobiology · 2026Review
- Interactions Between Inbreeding, Fitness and the Bacterial Microbiome inEvolutionary applications · 2026Article
- The sensory biology of mosquito gustation.Current opinion in neurobiology · 2026Review
- A Molecular and Cellular Mechanism for Bitter Taste in the mosquitobioRxiv : the preprint server for biology · 2026Article
- LncRNA modulates Dpp-mediated wing development to influence flight in Aedes aegypti.Cellular and molecular life sciences : CMLS · 2026Article
- Rapid urban evolution of the dengue mosquito in West African cities.bioRxiv : the preprint server for biology · 2026Article
- Transcriptional response of spermathecal secretory cells to mating and receipt of seminal fluid proteins iniScience · 2026Article
- Distinct genomic architectures but the same gene underlie the convergent evolution of a plant supergene.Science advances · 2026Article
- The first chromosome-scale genome assembly for Dermacentor reticulatus: a key vector of tick-borne pathogens of public and veterinary health importance in Europe.BMC biology · 2026Article
- Self-limiting population suppression gene drive design in the West Nile vector mosquito, Culex quinquefasciatus.Nature communications · 2026Article
281 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
72 authors at 20 institutions in 7 countries.
Benjamin J MatthewsLaboratory of Neurogenetics and Behavior, The Rockefeller University, New York, NY, USA. bnmtthws@gmail.com.
Olga DudchenkoThe Center for Genome Architecture, Baylor College of Medicine, Houston, TX, USA.
Sarah B KinganPacific Biosciences, Menlo Park, CA, USA.
Sergey KorenNational Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
Igor AntoshechkinDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA.
Jacob E CrawfordVerily Life Sciences, South San Francisco, CA, USA.
William J GlassfordMortimer B. Zuckerman Mind Brain Behavior Institute, Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY, USA.
Margaret HerreLaboratory of Neurogenetics and Behavior, The Rockefeller University, New York, NY, USA.
Seth N RedmondBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Noah H RoseDepartment of Ecology and Evolutionary Biology, Princeton University, Princeton, NJ, USA.
Gareth D WeedallVector Biology Department, Liverpool School of Tropical Medicine, Liverpool, UK.
Yang WuDepartment of Pathogen Biology, School of Public Health, Southern Medical University, Guangzhou, China.
Sanjit S BatraThe Center for Genome Architecture, Baylor College of Medicine, Houston, TX, USA.
Carlos A Brito-SierraDepartment of Entomology, Purdue University, West Lafayette, IN, USA.
Steven D BuckinghamCentre for Respiratory Biology, UCL Respiratory, University College London, London, UK.
Corey L CampbellDepartment of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO, USA.
Saki ChanBionano Genomics, San Diego, CA, USA.
Eric CoxNational Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD, USA.
Benjamin R EvansDepartment of Ecology and Evolutionary Biology, Yale University, New Haven, CT, USA.
Thanyalak FansiriVector Biology and Control Section, Department of Entomology, Armed Forces Research Institute of Medical Sciences (AFRIMS), Bangkok, Thailand.
Igor FilipovićMosquito Control Laboratory, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Albin FontaineInsect-Virus Interactions Group, Department of Genomes and Genetics, Institut Pasteur, Paris, France.
Andrea Gloria-SoriaDepartment of Ecology and Evolutionary Biology, Yale University, New Haven, CT, USA.
Richard HallPacific Biosciences, Menlo Park, CA, USA.
Vinita S JoardarNational Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD, USA.
Andrew K JonesDepartment of Biological and Medical Sciences, Faculty of Health and Life Sciences, Oxford Brookes University, Oxford, UK.
Raissa G G KayDepartment of Entomology, University of California Riverside, Riverside, CA, USA.
Vamsi K KodaliNational Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD, USA.
Joyce LeeBionano Genomics, San Diego, CA, USA.
Gareth J LycettVector Biology Department, Liverpool School of Tropical Medicine, Liverpool, UK.
Sara N MitchellVerily Life Sciences, South San Francisco, CA, USA.
Jill MuehlingPacific Biosciences, Menlo Park, CA, USA.
Michael R MurphyNational Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD, USA.
Arina D OmerThe Center for Genome Architecture, Baylor College of Medicine, Houston, TX, USA.
Frederick A PartridgeCentre for Respiratory Biology, UCL Respiratory, University College London, London, UK.
Paul PelusoPacific Biosciences, Menlo Park, CA, USA.
Aviva Presser AidenThe Center for Genome Architecture, Baylor College of Medicine, Houston, TX, USA.
Vidya RamasamyDepartment of Biological and Medical Sciences, Faculty of Health and Life Sciences, Oxford Brookes University, Oxford, UK.
Gordana RašićMosquito Control Laboratory, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Sourav RoyDepartment of Entomology, Center for Disease Vector Research and Institute for Integrative Genome Biology, University of California, Riverside, CA, USA.
Karla Saavedra-RodriguezDepartment of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO, USA.
Shruti SharanDepartment of Entomology, Purdue University, West Lafayette, IN, USA.
Atashi SharmaFralin Life Science Institute, Virginia Tech, Blacksburg, VA, USA.
Melissa Laird SmithPacific Biosciences, Menlo Park, CA, USA.
Joe TurnerInstitute of Integrative Biology, University of Liverpool, Liverpool, UK.
Allison M WeakleyVerily Life Sciences, South San Francisco, CA, USA.
Zhilei ZhaoDepartment of Ecology and Evolutionary Biology, Princeton University, Princeton, NJ, USA.
Omar S AkbariDivision of Biological Sciences, University of California, San Diego, La Jolla, CA, USA.
William C BlackDepartment of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO, USA.
Han CaoBionano Genomics, San Diego, CA, USA.
Alistair C DarbyInstitute of Integrative Biology, University of Liverpool, Liverpool, UK.
Catherine A HillDepartment of Entomology, Purdue University, West Lafayette, IN, USA.
J Spencer JohnstonDepartment of Entomology, Texas A&M University, College Station, TX, USA.
Terence D MurphyNational Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD, USA.
Alexander S RaikhelDepartment of Entomology, Center for Disease Vector Research and Institute for Integrative Genome Biology, University of California, Riverside, CA, USA.
David B SattelleCentre for Respiratory Biology, UCL Respiratory, University College London, London, UK.
Igor V SharakhovFralin Life Science Institute, Virginia Tech, Blacksburg, VA, USA.
Bradley J WhiteVerily Life Sciences, South San Francisco, CA, USA.
Li ZhaoLaboratory of Evolutionary Genetics and Genomics, The Rockefeller University, New York, NY, USA.
Erez Lieberman AidenThe Center for Genome Architecture, Baylor College of Medicine, Houston, TX, USA.
Richard S MannMortimer B. Zuckerman Mind Brain Behavior Institute, Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY, USA.
Louis LambrechtsInsect-Virus Interactions Group, Department of Genomes and Genetics, Institut Pasteur, Paris, France.
Jeffrey R PowellDepartment of Ecology and Evolutionary Biology, Yale University, New Haven, CT, USA.
Maria V SharakhovaFralin Life Science Institute, Virginia Tech, Blacksburg, VA, USA.
Zhijian TuDepartment of Biochemistry, Virginia Tech, Blacksburg, VA, USA.
Hugh M RobertsonDepartment of Entomology, University of Illinois at Urbana-Champaign, Urbana, IL, USA.
Carolyn S McBrideDepartment of Ecology and Evolutionary Biology, Princeton University, Princeton, NJ, USA.
Alex R HastieBionano Genomics, San Diego, CA, USA.
Jonas KorlachPacific Biosciences, Menlo Park, CA, USA.
Daniel E NeafseyBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Adam M PhillippyNational Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
Leslie B VosshallLaboratory of Neurogenetics and Behavior, The Rockefeller University, New York, NY, USA.
Pacific Biosciences (United States) · USVirginia Tech · USBioNano Genomics (United States) · USBaylor College of Medicine · USColorado State University · USNational Center for Biotechnology Information · USNational Institutes of Health · USPrinceton University · USPurdue University West Lafayette · USRockefeller University · USUniversity College London · GBUniversity of California, Riverside · USYale University · USColumbia University · USLiverpool School of Tropical Medicine · GBOxford Brookes University · GBQIMR Berghofer Medical Research Institute · AUUniversity of Liverpool · GBArmed Forces Research Institute of Medical Science · THBroad Institute · US
Funding
National Biomedical Information ServicesZIHLM200888 · NLM · NATIONAL LIBRARY OF MEDICINE · PI PALTOO, DINA · 2009 to 2025
$5200.7MViral Genomics: evolution, spread, and host interactionsU19AI110818 · NIAID · BROAD INSTITUTE, INC. · PI NEAFSEY, DANIEL E · 2014 to 2024
$66.5MWeill Cornell/Rockefeller/Sloan-Kettering MST ProgramT32GM007739 · NIGMS · WEILL MEDICAL COLL OF CORNELL UNIV · PI HSU, KATHARINE C · 1985 to 2023
$51.1MTransforming Translational Science and Education to Benefit Human HealthUL1TR000043 · NCATS · ROCKEFELLER UNIVERSITY · PI COLLER, BARRY · 2012 to 2015
$26.8MSingle-molecule sequence assembly and analysisZIAHG200398 · NHGRI · NATIONAL HUMAN GENOME RESEARCH INSTITUTE · PI PHILLIPPY, ADAM · 2016 to 2025
$15.9MInterpreting and Deploying Genomic Information During Animal DevelopmentR35GM118336 · NIGMS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI RICHARD S MANN · 2016 to 2026
$6.9MGENOME WIDE MAPPING OF LOOPS USING IN SITU HI-CUM1HG009375 · NHGRI · BAYLOR COLLEGE OF MEDICINE · PI LIEBERMAN-AIDEN, EREZ · 2017 to 2021
$4.7MSustainable Control of Aedes aegypti and epidemic dengueU01AI088647 · NIAID · COLORADO STATE UNIVERSITY · PI BLACK, WILLIAM C. · 2010 to 2014
$3.1MExploring how the genome folds through proximity ligation and sequencingDP2OD008540 · OD · BROAD INSTITUTE, INC. · PI LIEBERMAN-AIDEN, EREZ · 2011 to 2016
$3.0MMechanism and application of male determination in aedine mosquitoesR01AI123338 · NIAID · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI TU, ZHIJIAN JAKE · 2016 to 2020
$2.9MSupplement - Beyond pairwise DNA contacts: exploring higher-order genome structure using proximity ligationU01HL130010 · NHLBI · BAYLOR COLLEGE OF MEDICINE · PI LIEBERMAN-AIDEN, EREZ · 2015 to 2019
$2.3MGenetics of Vector Populations: Aedes aegypiR01AI101112 · NIAID · YALE UNIVERSITY · PI POWELL, JEFFREY R · 2012 to 2016
$2.1MBiotechnology and Biological Sciences Research Council BB/F021933/1FIC NIH HHS D43 TW001130Medical Research Council MC_PC_16052Medical Research Council MC_PC_16078NCATS NIH HHS UL1 TR000043NHGRI NIH HHS UM1 HG009375NHLBI NIH HHS U01 HL130010NIAID NIH HHS K22 AI113060NIAID NIH HHS R01 AI101112NIAID NIH HHS R01 AI121211NIAID NIH HHS R01 AI123338NIAID NIH HHS R21 AI121853NIAID NIH HHS R21 AI123937NIAID NIH HHS U01 AI088647NIAID NIH HHS U19 AI110818NIDCD NIH HHS F30 DC017658NIDCD NIH HHS R00 DC012069NIDCD NIH HHS R01 DC014247NIGMS NIH HHS R35 GM118336NIGMS NIH HHS T32 GM007739NIH HHS DP2 OD008540
Abstract
Female Aedes aegypti mosquitoes infect more than 400 million people each year with dangerous viral pathogens including dengue, yellow fever, Zika and chikungunya. Progress in understanding the biology of mosquitoes and developing the tools to fight them has been slowed by the lack of a high-quality genome assembly. Here we combine diverse technologies to produce the markedly improved, fully re-annotated AaegL5 genome assembly, and demonstrate how it accelerates mosquito science. We anchored physical and cytogenetic maps, doubled the number of known chemosensory ionotropic receptors that guide mosquitoes to human hosts and egg-laying sites, provided further insight into the size and composition of the sex-determining M locus, and revealed copy-number variation among glutathione S-transferase genes that are important for insecticide resistance. Using high-resolution quantitative trait locus and population genomic analyses, we mapped new candidates for dengue vector competence and insecticide resistance. AaegL5 will catalyse new biological insights and intervention strategies to fight this deadly disease vector.
Indexed as
ArbovirusesInsect ControlAedesAnimalsArbovirus InfectionsDengue VirusDNA Copy Number VariationsFemaleGenetics, PopulationGenetic VariationGenome, InsectGenomicsGlutathione TransferaseInsecticide ResistanceMaleMolecular Sequence AnnotationGlutathione TransferasePyrethrins
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