ArticleNature2018
Sensitive tumour detection and classification using plasma cell-free DNA methylomes.
2 registry-linked trialsOpen access · greenAbstract read
In one paragraph
Article in Nature, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 583 papers, 3 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
583citing papers in PubMed, 3 pooled it
29.4field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Concordance Between Liquid and Tissue Biopsy in Newly Diagnosed Metastatic Breast Cancer
Comparison of Diagnostic Sensitivity Between Circulating Tumor DNA Methylation and Carcinoembryonic Antigen in Colorectal Cancer
Who cites it
583 citing papers in PubMed, 3 syntheses or guidelines pooled it, 987 citations in OpenAlex.
- Clinical utility of liquid biopsy in distinguishing true progression from radiation necrosis and pseudoprogression in malignant brain tumor.Journal of neuro-oncology · 2026Pooled it
- [Liquid Biopsy Revolutionizes the Precise Management of Tumors Across the Entire Course: Current Situation and Future Prospects].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2026Pooled it
- Blood-Based Circulating Tumor DNA for Early Detection of Colorectal Cancer: A Systematic Review and Meta-Analysis.Digestive diseases (Basel, Switzerland) · 2026Pooled it
- Diagnostic Performance of cfDNA-Based Liquid Biopsy for Hepatocellular Carcinoma: A Systematic Review and Meta-Analysis.Cancer science · 2026Review
- Article
- Liquid surrogates of spatial tumor ecosystems.Cell research · 2026Article
- Nutrigenomics and Epigenetic Regulation in Cancer Prevention: Molecular Mechanisms, Dietary Bioactives, and Translational Perspectives.Nutrients · 2026Review
- Exercise-associated epigenetic remodeling and TCR repertoire dynamics in Lynch syndrome carriers.iScience · 2026Article
- Identification of a G-quadruplex-forming cell-free DNA fragment as a biomarker for the precise diagnosis of hepatocellular carcinoma.Chemical science · 2026Article
- Circulating Cell-Free DNA Methylation Profiling Enables Detection, Distinction, and Estrogen Receptor Status Classification of Advanced Breast Cancer.Cancer research · 2026Article
- Written in blood: DNA methylation in liquid biopsy.Nature reviews. Genetics · 2026Article
- LINE-1 Deregulation in Ovarian Cancer: Implications for Diagnosis, Prognosis, and Therapeutic Targeting.Molecular diagnosis & therapy · 2026Review
- Beyond Detection Limits: Integrated Biosensors for Molecular Diagnostics, Longitudinal Monitoring, and Clinical Translation.Biosensors · 2026Review
- Liquid biopsy in solid tumours: expert opinion paper of the European society of pathology.Virchows Archiv : an international journal of pathology · 2026Review
- Epigenetic Profiling for Early Detection and Treatment Response Monitoring in Non-Small Cell Lung Cancer: Protocol for a Prospective Translational Biomarker Study.JMIR research protocols · 2026Article
- Epigenetics in development, disease, and therapy: from mechanisms to clinical interventions.Science China. Life sciences · 2026Review
- Protocol for detecting cancer in blood using targeted DNA methylation.STAR protocols · 2026Article
- Cerebrospinal fluid cell-free DNA sequencing in pediatric CNS tumors: towards liquid molecular neuropathology.Acta neuropathologica · 2026Review
- Integration of breaking-point transition probabilities and specific open chromatin region features for early cancer detection.Cell communication and signaling : CCS · 2026Article
- Genome-wide methylome profiling of cell-free DNA enables prognostication of patients with castration-resistant prostate cancer.British journal of cancer · 2026Article
523 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
Authors and funding
38 authors at 9 institutions in 3 countries.
Shu Yi ShenPrincess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.
Rajat SinghaniaPrincess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.
Gordon FehringerLunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, Ontario, Canada.
Ankur ChakravarthyPrincess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.
Michael H A RoehrlPrincess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.
Dianne ChadwickPrincess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.
Philip C ZuzarteGenome Technologies, Ontario Institute for Cancer Research, Toronto, Ontario, Canada.
Ayelet BorgidaLunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, Ontario, Canada.
Ting Ting WangPrincess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.
Tiantian LiPrincess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.
Olena KisPrincess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.
Zhen ZhaoPrincess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.
Anna SpreaficoPrincess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.
Tiago da Silva MedinaPrincess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.
Yadon WangPrincess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.
David RouloisPrincess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.
Ilias EttayebiPrincess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.
Zhuo ChenPrincess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.
Signy ChowPrincess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.
Tracy MurphyPrincess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.
Andrea ArrudaPrincess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.
Grainne M O'KanePrincess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.
Jessica LiuDepartment of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada.
Mark MansourDepartment of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada.
John D McPhersonDepartment of Biochemistry and Molecular Medicine, UC Davis Comprehensive Cancer Center, Sacramento, CA, USA.
Catherine O'BrienPrincess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.
Natasha LeighlPrincess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.
Philippe L BedardPrincess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.
Neil FleshnerPrincess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.
Geoffrey LiuPrincess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.
Mark D MindenPrincess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.
Steven GallingerFred Litwin Centre for Cancer Genetics, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada.
Anna GoldenbergDepartment of Computer Science, University of Toronto, Toronto, Ontario, Canada.
Trevor J PughPrincess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.
Michael M HoffmanPrincess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.
Scott V BratmanPrincess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.
Rayjean J HungLunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, Ontario, Canada. rayjean.hung@lunenfeld.ca.
Daniel D De CarvalhoPrincess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada. ddecarv@uhnresearch.ca.
University Health Network · CAPrincess Margaret Cancer Centre · CAUniversity of Toronto · CALunenfeld-Tanenbaum Research Institute · CASinai Health System · CAInserm · FRMemorial Sloan Kettering Cancer Center · USOntario Institute for Cancer Research · CAUniversity of California, Davis · US
Funding
No grant is acknowledged in the PubMed record.
Abstract
The use of liquid biopsies for cancer detection and management is rapidly gaining prominence
Indexed as
DNA MethylationAdenocarcinomaAnimalsBiomarkers, TumorCell-Free Nucleic AcidsCell Line, TumorColorectal NeoplasmsDNA Mutational AnalysisDNA, NeoplasmEarly Detection of CancerEpigenesis, GeneticFemaleHeterograftsHumansLiquid BiopsyMaleBiomarkers, TumorCell-Free Nucleic AcidsDNA, Neoplasm
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
NCT04241237ClinicalTrials.gov
NCT05558436ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.