ArticleNature2018
Autophagy maintains tumour growth through circulating arginine.
Erratum issuedAbstract read
In one paragraph
Article in Nature, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 223 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
223citing papers in PubMed, 1 pooled it
30.5field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
223 citing papers in PubMed, 1 synthesis or guideline pooled it, 371 citations in OpenAlex.
- Emerging roles of ATG7 in human health and disease.EMBO molecular medicine · 2021Pooled it
- Lysosomal metabolism in pancreatic cancer and its crosstalk with host physiology.Genes & development · 2026Review
- Drugging small-molecule compounds in autophagy-dependent cell death to overcome cancer therapy resistance.Apoptosis : an international journal on programmed cell death · 2026Review
- Autophagy modulation in cancer.Nature reviews. Drug discovery · 2026Review
- Metabolism, autophagy, and cell death: The triangular axis in tumor survival and therapeutic resistance.Redox biology · 2026Review
- Article
- Article
- The Role of Crosstalk Between the Unfolded Protein Response and Autophagy in Diseases Associated with Sympathetic Nervous System Imbalance: Mechanisms and Therapeutic Perspectives.International journal of molecular sciences · 2026Review
- Autophagy in the liver.Autophagy reports · 2026Review
- XPC Deficiency Activate Cisplatin-Mediated Autophagy in Bladder Cancer by Limiting Novel PHRF1-Mediated Ubiquitination of the p53 Protein.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Ammonia metabolic reprogramming in the tumor microenvironment: emergence of an immunosuppressive niche.Frontiers in cell and developmental biology · 2026Review
- Targeting autophagy and metabolism for ewing sarcoma.Molecular biology reports · 2025Review
- A autophagy related gene signature to predict the prognosis of pancreatic carcinoma and tumor immune microenvironment evaluation.Scientific reports · 2025Article
- Attack cancer: Through autophagic modulations as suppressor or promoter.World journal of clinical oncology · 2025Review
- The role and application prospects of ANXA1 in gastric cancer cells.Medical oncology (Northwood, London, England) · 2025Review
- Nutrient stress diverts RRN3 from rRNA transcription to alternative polyadenylation of autophagy mRNAs in ovarian cancer.Cell death & disease · 2025Article
- Acute liver failure-induced arginine deficiency impairs blood-brain barrier via inhibiting mTORC1-S6K1/4EBP1 pathway and inducing autophagy.Cell death & disease · 2025Article
- Autophagy acts as a brake on obesity-related fibrosis by controlling purine nucleoside signalling.Nature communications · 2025Article
- Autophagy disruption primes CAR-T cell metabolism for sustained rejection of ovarian tumors.bioRxiv : the preprint server for biology · 2025Article
- Respiration defects limit serine synthesis required for lung cancer growth and survival.Nature communications · 2025Article
163 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
- Commented on by
- Commented on by
- Erratum issued
Authors and funding
17 authors at 5 institutions in 1 country.
Laura Poillet-PerezRutgers Cancer Institute of New Jersey, New Brunswick, NJ, USA.
Xiaoqi XieRutgers Cancer Institute of New Jersey, New Brunswick, NJ, USA.
Le ZhanRutgers Cancer Institute of New Jersey, New Brunswick, NJ, USA.
Yang YangRutgers Cancer Institute of New Jersey, New Brunswick, NJ, USA.
Daniel W SharpRutgers Cancer Institute of New Jersey, New Brunswick, NJ, USA.
Zhixian Sherrie HuRutgers Cancer Institute of New Jersey, New Brunswick, NJ, USA.
Xiaoyang SuRutgers Cancer Institute of New Jersey, New Brunswick, NJ, USA.
Anurag MagantiRutgers Cancer Institute of New Jersey, New Brunswick, NJ, USA.
Cherry JiangRutgers Cancer Institute of New Jersey, New Brunswick, NJ, USA.
Wenyun LuDepartment of Chemistry and Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ, USA.
Haiyan ZhengBiological Mass Spectrometry Facility, Rutgers University, Robert Wood Johnson Medical School, Rutgers University, Piscataway, NJ, USA.
Marcus W BosenbergDepartment of Pathology, Yale University School of Medicine, New Haven, CT, USA.
Janice M MehnertRutgers Cancer Institute of New Jersey, New Brunswick, NJ, USA.
Jessie Yanxiang GuoRutgers Cancer Institute of New Jersey, New Brunswick, NJ, USA.
Edmund LattimeRutgers Cancer Institute of New Jersey, New Brunswick, NJ, USA.
Joshua D RabinowitzRutgers Cancer Institute of New Jersey, New Brunswick, NJ, USA.
Eileen WhiteRutgers Cancer Institute of New Jersey, New Brunswick, NJ, USA. epwhite@cinj.rutgers.edu.
Rutgers, The State University of New Jersey · USRutgers Cancer Institute of New JerseyJohnson University · USPrinceton University · USYale University · US
Funding
TRANSCRIPTIONAL PROFILINGP30CA072720 · NCI · UNIV OF MED/DENT NJ-R W JOHNSON MED SCH · PI Tracie Saunders · 1997 to 2026
$94.5MTumor cell metabolism in actionR01CA163591 · NCI · RUTGERS, THE STATE UNIV OF N.J. · PI JOSHUA D RABINOWITZ, Eileen P. White · 2012 to 2026
$7.0MRole of Autophagy in CancerR01CA130893 · NCI · RUTGERS, THE STATE UNIV OF N.J. · PI WHITE, EILEEN P. · 2008 to 2017
$3.4MTargeting Autophagy in Hereditary Breast CancerR01CA188096 · NCI · RBHS -CANCER INSTITUTE OF NEW JERSEY · PI WHITE, EILEEN P., XIA, BING · 2015 to 2019
$2.4MPromoting Bim-driven apoptosis through MAPK inhibition: A therapeutic strategy in advanced melanomaR01CA193970 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI MEHNERT, JANICE M., SULLIVAN, RYAN J · 2016 to 2020
$2.3MCongenic Mouse Medels of Melanoma for the Characterization of Tumor Immune ResponsesR01CA196660 · NCI · YALE UNIVERSITY · PI BOSENBERG, MARCUS W · 2016 to 2018
$1.7MRevealing cancer metabolism via mass spectrometry and isotope tracersR50CA211437 · NCI · PRINCETON UNIVERSITY · PI Wenyun Lu · 2016 to 2026
$1.3MThe role of autophagy in Kras-driven lung cancerK22CA190521 · NCI · RBHS -CANCER INSTITUTE OF NEW JERSEY · PI GUO, YANXIANG · 2015 to 2017
$629kA Mass Spectrometry System for Quantitative ProteomicsS10OD016400 · OD · RBHS-ROBERT WOOD JOHNSON MEDICAL SCHOOL · PI LOBEL, PETER · 2014 to 2014
$561kNCI NIH HHS K22 CA190521NCI NIH HHS P30 CA072720NCI NIH HHS R01 CA130893NCI NIH HHS R01 CA163591NCI NIH HHS R01 CA188096NCI NIH HHS R01 CA193970NCI NIH HHS R01 CA196660NCI NIH HHS R50 CA211437NIH HHS S10 OD016400
Abstract
Autophagy captures intracellular components and delivers them to lysosomes, where they are degraded and recycled to sustain metabolism and to enable survival during starvation
Indexed as
AutophagyAllograftsAnimalsArginaseArginineAutophagy-Related Protein 5Autophagy-Related Protein 7CarcinogenesisCell ProliferationDietary SupplementsHepatocytesLiverMaleMiceNeoplasmsNeoplasm TransplantationArg1 protein, mouseArginaseArginineAtg5 protein, mouseAtg7 protein, mouseAutophagy-Related Protein 5Autophagy-Related Protein 7Ornithine
Identifiers
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.