ArticleScience translational medicine2018
Commensal bacteria contribute to insulin resistance in aging by activating innate B1a cells.
Registry-linked trialOpen access · greenAbstract read
In one paragraph
Article in Science translational medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07422896 (A Phase I First-in-human Trial of Bvax), which is not on this map. Cited by 120 papers.
0numbers the graph read from it
0cells of the map it votes in
120citing papers in PubMed
6.1field-weighted citation impact, top 3% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
NCT07422896 phase1not yet recruitingnot on this mapstarted 2026, after this paper: background citation
A Phase I First-in-human Trial of Bvax (B-cell Vaccination) in Addition to Standard of Care Chemoradiotherapy for Newly Diagnosed Glioblastoma
Who cites it
120 citing papers in PubMed, 178 citations in OpenAlex.
- Akkermansia muciniphila and Its Bioactive Derivatives: Emerging Regulators of Healthy Aging.Aging cell · 2026Review
- The ageing immune system as a driver of systemic ageing.Nature reviews. Immunology · 2026Review
- Gut microbiota-modulated glutamic acid rejuvenates the quality of oocytes deteriorated by advanced reproductive age.EMBO molecular medicine · 2026Article
- Unlocking the role of microbiome through gut-skin axis to alleviate aging: current perspectives and future scope.GeroScience · 2026Review
- B cells drive CD4 T cell immunosenescence and age-associated health decline.Science immunology · 2026Article
- Mental health and gut-brain crosstalk: implications for depression and Alzheimer's disease.Neuroscience applied · 2026Review
- Article
- Balancing harm and harmony: Evolutionary dynamics between gut microbiota-derived flagellin and TLR5-mediated host immunity and metabolism.Virulence · 2025Review
- Comparative gut microbiota, growth performances, and cytokine indices in broiler chickens with or without litter.Journal of animal science and technology · 2025Article
- Therapeutic potential of traditional Chinese medicine and mechanisms for the treatment of type 2 diabetes mellitus.Chinese medicine · 2025Review
- Comparative Pain Expression and Its Association to Intestinal Microbiota Through the MI-RAT© Osteoarthritis Model Induced in LOU/C/Jall and Sprague-Dawley Aged Rats.International journal of molecular sciences · 2025Article
- The Small Intestinal Microbiota and the Gut-Brain Axis in Parkinson's Disease: A Narrative Review.Biomedicines · 2025Review
- Microbiome-based therapeutics towards healthier aging and longevity.Genome medicine · 2025Review
- Gut-vitamin D interplay: key to mitigating immunosenescence and promoting healthy ageing.Immunity & ageing : I & A · 2025Review
- Article
- Aging immunity: unraveling the complex nexus of diet, gut microbiome, and immune function.Immunometabolism (Cobham, Surrey) · 2025Review
- Achieving healthy aging through gut microbiota-directed dietary intervention: Focusing on microbial biomarkers and host mechanisms.Journal of advanced research · 2025Review
- Regulatory Roles for SIRT1 in Aging and Immunosenescence.Results and problems in cell differentiation · 2025Review
- Health and aging trajectories: shared and competing risks and resiliencies for chronic diseases associated with aging. A NIH-wide workshop.Frontiers in public health · 2025Article
- Targeting gut microbiota to regulate the adaptive immune response in atherosclerosis.Frontiers in cardiovascular medicine · 2025Review
60 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
27 authors at 8 institutions in 5 countries.
Monica BodogaiImmunoregulation Section, National Institute on Aging, Baltimore, MD 21224, USA.ORCID 0000-0002-8174-9608
Jennifer O'ConnellLaboratory of Clinical Investigation, National Institute on Aging, Baltimore, MD 21224, USA.ORCID 0000-0002-4679-0023
Ki KimImmunoregulation Section, National Institute on Aging, Baltimore, MD 21224, USA.ORCID 0000-0002-8028-0772
Yoo KimLaboratory of Clinical Investigation, National Institute on Aging, Baltimore, MD 21224, USA.ORCID 0000-0002-4525-1319
Kanako MoritohImmunoregulation Section, National Institute on Aging, Baltimore, MD 21224, USA.ORCID 0000-0001-7501-6806
Chen ChenImmunoregulation Section, National Institute on Aging, Baltimore, MD 21224, USA.
Fedor GusevDepartment of Genomics and Human Genetics, Vavilov Institute of General Genetics, Russian Academy of Sciences, Moscow, Russia.ORCID 0000-0001-9859-4721
Kelli VaughanNonhuman Primate Core Facility, National Institute on Aging, Baltimore, MD 21224, USA.ORCID 0000-0001-5274-582X
Natalia ShulzhenkoCollege of Veterinary Medicine, Oregon State University, Corvallis, OR 97331, USA.
Julie A MattisonNonhuman Primate Core Facility, National Institute on Aging, Baltimore, MD 21224, USA.
Catalina Lee-ChangBrudnick Neuropsychiatric Research Institute, University of Massachusetts Medical School, Worcester, MA 01604, USA.
Weixuan ChenJanssen Research & Development, San Diego, CA 92121, USA.
Olga CarlsonLaboratory of Clinical Investigation, National Institute on Aging, Baltimore, MD 21224, USA.
Kevin G BeckerLaboratory of Genetics, National Institute on Aging, Baltimore, MD 21224, USA.ORCID 0000-0002-6794-6656
Manoj GurungCollege of Veterinary Medicine, Oregon State University, Corvallis, OR 97331, USA.ORCID 0000-0002-5652-5688
Andrey MorgunCollege of Pharmacy, Oregon State University, Corvallis, OR 97331, USA.
James WhiteResphera Biosciences, Baltimore, MD 21231, USA.
Theresa MeadeComparative Medicine Section, National Institute on Aging, Baltimore, MD 21224, USA.ORCID 0000-0002-4237-6829
Kathy PerdueComparative Medicine Section, National Institute on Aging, Baltimore, MD 21224, USA.
Matthias MackDepartment of Nephrology, Universitätsklinikum Regensburg, Regensburg 93001-93059, Germany.
Luigi FerrucciLongitudinal Studies Section, Translational Gerontology Branch, National Institute on Aging, Baltimore, MD 21224, USA.ORCID 0000-0002-6273-1613
Giorgio TrinchieriCancer Inflammation Program, National Cancer Institute, Frederick, MD 21701, USA.
Rafael de CaboLongitudinal Studies Section, Translational Gerontology Branch, National Institute on Aging, Baltimore, MD 21224, USA.
Evgeny RogaevDepartment of Genomics and Human Genetics, Vavilov Institute of General Genetics, Russian Academy of Sciences, Moscow, Russia.
Josephine EganLaboratory of Clinical Investigation, National Institute on Aging, Baltimore, MD 21224, USA.
Jiejun WuJanssen Research & Development, San Diego, CA 92121, USA.ORCID 0000-0003-0132-8211
Arya BiragynImmunoregulation Section, National Institute on Aging, Baltimore, MD 21224, USA. biragyna@mail.nih.gov.ORCID 0000-0001-5276-6102
National Institute on Aging · USOregon State University · USJanssen (Belgium) · BEUniversity of Massachusetts Chan Medical School · USFrederick National Laboratory for Cancer Research · USResphera Biosciences · USUniversity Hospital Regensburg · DEVavilov Institute of General Genetics · RU
Funding
Role of mouse microbiome in cancer and inflammationZIABC011153 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI TRINCHIERI, GIORGIO · 2009 to 2025
$22.0MAging Intervention StudiesZIAAG000356 · NIA · NATIONAL INSTITUTE ON AGING · PI MATTISON, JULIE · 2013 to 2025
$21.7MAnalysis of complex biological systems by microarray based gene expressionZICAG000616 · NIA · NATIONAL INSTITUTE ON AGING · PI DE, SUPRIYO · 2009 to 2025
$15.5MNovel immunotherapeutic strategies to treat cancer and diseases of old peopleZIAAG000770 · NIA · NATIONAL INSTITUTE ON AGING · PI BIRAGYN, ARYA · 2009 to 2025
$13.0MCalorie restriction and agingZIAAG000368 · NIA · NATIONAL INSTITUTE ON AGING · PI DE CABO, RAFAEL · 2009 to 2025
$6.9MEpigenetic-Genetic Modulations in Aging and Alzheimer's Disease NeuronsR01AG054712 · NIA · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI ROGAEV, EVGENY I · 2017 to 2021
$3.3MGut microbiota mediates the interplay between immunity and glucose metabolismR01DK103761 · NIDDK · OREGON STATE UNIVERSITY · PI SHULZHENKO, NATALIA · 2015 to 2019
$1.7MIntramural NIH HHS Z99 AG999999NIA NIH HHS R01 AG054712NIDDK NIH HHS R01 DK103761
Abstract
Aging in humans is associated with increased hyperglycemia and insulin resistance (collectively termed IR) and dysregulation of the immune system. However, the causative factors underlying their association remain unknown. Here, using "healthy" aged mice and macaques, we found that IR was induced by activated innate 4-1BBL
Indexed as
Immunity, InnateInsulin ResistanceAgingAnimalsBacteriaButyratesCell LineDysbiosisEnrofloxacinFemaleGastrointestinal MicrobiomeMacacaMice, Inbred C57BLMonocytesOmentumReceptors, CCR2ButyratesEnrofloxacinReceptors, CCR2
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Read underepoch 390
Registered trials
NCT07422896ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.