Evidence map›Paper›PMID 30429338›Full record

ArticleJournal of virology2019

A Measles Virus-Based Vaccine Candidate Mediates Protection against Zika Virus in an Allogeneic Mouse Pregnancy Model.

Cindy Nürnberger, Bianca S Bodmer, Anna H Fiedler, Gülsah Gabriel, Michael D Mühlebach

Open access · bronzeAbstract read
In one paragraph

Article in Journal of virology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed
5.8field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

48 citing papers in PubMed, 67 citations in OpenAlex.

  1. Trial
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  4. An updated review of Zika virus vaccine development.Clinical and experimental vaccine research · 2025
    Review
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  6. Article
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  9. A review on Zika vaccine development.Pathogens and disease · 2024
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Cindy Nürnberger *Veterinary Medicine Division, Paul-Ehrlich-Institut, Langen, Germany.
Bianca S Bodmer *Veterinary Medicine Division, Paul-Ehrlich-Institut, Langen, Germany.
Anna H FiedlerVeterinary Medicine Division, Paul-Ehrlich-Institut, Langen, Germany.
Gülsah GabrielHeinrich Pette Institute, Leibniz Institute for Experimental Virology, Hamburg, Germany.
Michael D MühlebachVeterinary Medicine Division, Paul-Ehrlich-Institut, Langen, Germany Michael.Muehlebach@pei.de.ORCID 0000-0002-7069-5018
German Center for Infection Research · DELeibniz Institute of Virology (LIV) · DEPaul Ehrlich Institut · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The impact of the Zika virus (ZIKV) epidemic highlights the need for vaccines that reduce or prevent infection and reliably prevent teratogenic complications. The live-attenuated measles virus (MV) vaccine strains are a promising vaccine platform, since they induce robust humoral and cellular immune responses against additional antigens and have an excellent safety record. To explore its potential to protect against ZIKV, we compared a recombinant Schwarz strain MV that encodes ZIKV prM and soluble E proteins (MV-Zika-sE) with a prototypic alum-adjuvanted whole inactivated ZIKV particle vaccine. Analysis of MV-Zika-sE-infected cells confirmed antigen expression, and the virus replicated with vaccine strain characteristics. Immunized IFNAR

Indexed as

Disease Models, AnimalAnimalsAntibodies, ViralFemaleGenome, ViralImmunity, CellularImmunity, HumoralMeasles VaccineMeasles virusMembrane Cofactor ProteinMiceMice, Inbred BALB CMice, KnockoutPregnancyReceptor, Interferon alpha-betaVaccinationAntibodies, ViralIfnar1 protein, mouseMcp protein, mouseMeasles VaccineMembrane Cofactor ProteinReceptor, Interferon alpha-betaVaccines, AttenuatedViral Envelope Proteinsallogeneic pregnancy modelimmunizationmeasles virusteratogenic infectionvaccinesZika virusZIKV pathology

Identifiers

PMID30429338
PMCPMC6340036
OpenAlexW2899717028

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.