Evidence map›Paper›PMID 30429336›Full record

ArticleJournal of virology2019

RNA Sequencing of the

Joshua A Hill, Minako Ikoma, Danielle M Zerr, Ryan S Basom, Vikas Peddu, Meei-Li Huang, Ruth Hall Sedlak, Keith R Jerome, Michael Boeckh, Serge Barcy

Open access · bronzeAbstract read
In one paragraph

Article in Journal of virology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
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  11. Review
  12. Review
  13. Human Herpesvirus 6B and Lower Respiratory Tract Disease After Hematopoietic Cell Transplantation.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2019
    Article
  14. RNA Sequencing of theJournal of virology · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Joshua A HillDepartment of Medicine, University of Washington, Seattle, Washington, USA jahill3@fredhutch.org.ORCID 0000-0002-7665-7100
Minako IkomaSeattle Children's Research Institute, Seattle, Washington, USA.
Danielle M ZerrVaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.
Ryan S BasomGenomics and Bioinformatics Shared Resource, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.
Vikas PedduDepartment of Laboratory Medicine, University of Washington, Seattle, Washington, USA.
Meei-Li HuangDepartment of Laboratory Medicine, University of Washington, Seattle, Washington, USA.
Ruth Hall SedlakDepartment of Laboratory Medicine, University of Washington, Seattle, Washington, USA.
Keith R JeromeDepartment of Laboratory Medicine, University of Washington, Seattle, Washington, USA.
Michael BoeckhDepartment of Medicine, University of Washington, Seattle, Washington, USA.
Serge BarcySeattle Children's Research Institute, Seattle, Washington, USA.
University of Washington · USFred Hutch Cancer Center · US

Funding

Translational Bioimaging Core Shared ResourceP30CA015704 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI Marian Esvelt · 1985 to 2026
$296.4M
VIRUS-MEDIATED MYELOSUPPRESSIONP01CA018029 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI Evan Newell · 1985 to 2026
$128.4M
Project 3: Stem Cell Allografts for Lymphoid MalignanciesP01CA078902 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI SANDMAIER, BRENDA MARIE · 1999 to 2025
$46.1M
Project 3: Gene Therapy for Correction of Blood DisordersP01HL122173 · NHLBI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI KIEM, HANS-PETER · 2015 to 2019
$12.9M
Notch-Mediated Expansion of Cord Blood Progenitors for Stem Cell TransplantP50HL110787 · NHLBI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI DELANEY, COLLEEN · 2012 to 2017
$12.4M
Infections in Hematopoietic Cell Transplant RecipientsK24HL093294 · NHLBI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI BOECKH, MICHAEL J · 2009 to 2019
$1.5M
Human Herpesvirus 6 in Lower Respiratory Tract Disease and Chromosomal Integration after Hematopoietic Cell TransplantationK23AI119133 · NIAID · FRED HUTCHINSON CANCER RESEARCH CENTER · PI HILL, JOSHUA AIDEN · 2015 to 2019
$922k
Impact of Comorbidities on Outcomes of Allogeneic TransplantationR00HL088021 · NHLBI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI SORROR, MOHAMED · 2011 to 2013
$735k
Impact of Comorbidities on Outcomes of Allogeneic TransplantationK99HL088021 · NHLBI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI SORROR, MOHAMED · 2007 to 2008
$178k
NCI NIH HHS P01 CA018029NCI NIH HHS P01 CA078902NCI NIH HHS P30 CA015704NHLBI NIH HHS K24 HL093294NHLBI NIH HHS K99 HL088021NHLBI NIH HHS P01 HL122173NHLBI NIH HHS P50 HL110787NHLBI NIH HHS R00 HL088021NIAID NIH HHS K23 AI119133
6 · The paper itself

Abstract

Human herpesvirus 6B (HHV-6B) DNA is frequently detected in human samples. Diagnostic assays distinguishing HHV-6B reactivation from latency are limited. This has impaired strategies to diagnose and treat HHV-6B-associated diseases. We used RNA sequencing to characterize and compare the HHV-6B transcriptome in multiple sample types, including (i) whole blood from hematopoietic cell transplant (HCT) recipients with and without HHV-6B plasma viremia, (ii) tumor tissue samples from subjects with large B cell lymphoma infected with HHV-6B, (iii) lymphoblastoid cell lines (LCLs) from subjects with inherited chromosomally integrated HHV-6B or latent infection with HHV-6B, and (iv) HHV-6B Z29 infected SupT1 CD4

Indexed as

TranscriptomeVirus ActivationVirus LatencyAdultAgedBiomarkersCase-Control StudiesCytokinesDNA, ViralFemaleHerpesvirus 6, HumanHigh-Throughput Nucleotide SequencingHumansLymphoma, Large B-Cell, DiffuseMaleMiddle AgedBiomarkersCytokinesDNA, ViralViral Proteinsbone marrow transplantationdiagnosediagnosticsgene sequencingherpesHHV-6human herpesvirusesRNA-seqRNA sequencingtranscriptiontranscriptometransplanttransplant infectious diseases

Identifiers

PMID30429336
PMCPMC6340040
OpenAlexW2888026563

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.