Evidence map›Paper›PMID 30429335›Full record

ArticleJournal of virology2019

Endosomal Toll-Like Receptors 7 and 9 Cooperate in Detection of Murine Gammaherpesvirus 68 Infection.

Kendra A Bussey, Sripriya Murthy, Elisa Reimer, Baca Chan, Bastian Hatesuer, Klaus Schughart, Britt Glaunsinger, Heiko Adler, Melanie M Brinkmann

Open access · bronzeAbstract read
In one paragraph

Article in Journal of virology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 28 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 2 countries.

Kendra A BusseyInstitute of Genetics, Technische Universität Braunschweig, Braunschweig, Germany.
Sripriya MurthyViral Immune Modulation Research Group, Helmholtz Centre for Infection Research, Braunschweig, Germany.
Elisa ReimerViral Immune Modulation Research Group, Helmholtz Centre for Infection Research, Braunschweig, Germany.
Baca ChanViral Immune Modulation Research Group, Helmholtz Centre for Infection Research, Braunschweig, Germany.
Bastian HatesuerDepartment of Infection Genetics, Helmholtz Centre for Infection Research, Braunschweig, Germany.
Klaus SchughartDepartment of Infection Genetics, Helmholtz Centre for Infection Research, Braunschweig, Germany.
Britt GlaunsingerDepartment of Plant and Microbial Biology, University of California Berkeley, Howard Hughes Medical Institute, Berkeley, California, USA.
Heiko AdlerComprehensive Pneumology Center, Research Unit Lung Repair and Regeneration, Helmholtz Zentrum München-German Research Center for Environmental Health, German Center of Lung Research, Munich, Germany.
Melanie M BrinkmannInstitute of Genetics, Technische Universität Braunschweig, Braunschweig, Germany m.brinkmann@tu-braunschweig.de.
Helmholtz Centre for Infection Research · DETechnische Universität Braunschweig · DEHelmholtz Zentrum München · DEUniversity of California, Berkeley · USUniversity of Tennessee Health Science Center · US

Funding

Disruption of Cellular RNA Processing by Kaposi's Sarcoma-Associated HerpesvirusR01CA136367 · NCI · UNIVERSITY OF CALIFORNIA BERKELEY · PI Britt A Glaunsinger · 2010 to 2026
$5.8M
NCI NIH HHS R01 CA136367
6 · The paper itself

Abstract

Murine gammaherpesvirus 68 (MHV68) is a small-animal model suitable for study of the human pathogens Epstein-Barr virus and Kaposi's sarcoma-associated herpesvirus. Here, we have characterized the roles of the endosomal Toll-like receptor (TLR) escort protein UNC93B, endosomal TLR7, -9, and -13, and cell surface TLR2 in MHV68 detection. We found that the alpha interferon (IFN-α) response of plasmacytoid dendritic cells (pDC) to MHV68 was reduced in

Indexed as

AnimalsDendritic CellsEndosomesFemaleGammaherpesvirinaeHerpesviridae InfectionsMembrane GlycoproteinsMesenchymal Stem CellsMiceMice, Inbred C57BLMice, KnockoutSignal TransductionToll-Like Receptor 7Toll-Like Receptor 9Virus ActivationVirus LatencyMembrane GlycoproteinsTlr7 protein, mouseTlr9 protein, mouseToll-Like Receptor 7Toll-Like Receptor 9dendritic cellsherpesvirusesMHV68murine gammaherpesvirus 68pattern recognition receptorToll-like receptortype I interferon

Identifiers

PMID30429335
PMCPMC6340039
OpenAlexW2899856583

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.