Evidence map›Paper›PMID 30429332›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2018

Global impacts of chromosomal imbalance on gene expression in

Jie Hou, Xiaowen Shi, Chen Chen, Md Soliman Islam, Adam F Johnson, Tatsuo Kanno, Bruno Huettel, Ming-Ren Yen, Fei-Man Hsu, Tieming Ji and 5 more

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed
9.8field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 81 citations in OpenAlex.

  1. Nonlinearities and Switch-Like Behavior in Gene Expression: From Genetics to Biochemistry and Back.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026
    Review
  2. Article
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  7. Gene Dosage Sensitivity and Human Genetic Diseases.Journal of inherited metabolic disease · 2025
    Review
  8. Article
  9. Global modulation of gene expression and transcriptome size in aneuploid combinations of maize.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  10. Article
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  17. Aneuploidy effects on human gene expression across three cell types.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  18. Article
  19. A fitness trade-off explains the early fate of yeast aneuploids with chromosome gains.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 5 countries.

Jie HouDepartment of Electrical Engineering and Computer Science, University of Missouri, Columbia, MO 65211.
Xiaowen ShiDivision of Biological Sciences, University of Missouri, Columbia, MO 65211.
Chen ChenDepartment of Electrical Engineering and Computer Science, University of Missouri, Columbia, MO 65211.
Md Soliman IslamDepartment of Electrical Engineering and Computer Science, University of Missouri, Columbia, MO 65211.
Adam F JohnsonDivision of Biological Sciences, University of Missouri, Columbia, MO 65211.
Tatsuo KannoInstitute of Plant and Microbial Biology, Academia Sinica, Taipei, Taiwan 11529.
Bruno HuettelMax Planck Institute for Plant Breeding, Cologne, Germany 50829.
Ming-Ren YenInstitute of Plant and Microbial Biology, Academia Sinica, Taipei, Taiwan 11529.ORCID 0000-0002-9012-3244
Fei-Man HsuInstitute of Plant and Microbial Biology, Academia Sinica, Taipei, Taiwan 11529.ORCID 0000-0002-9901-7464
Tieming JiDepartment of Statistics, University of Missouri, Columbia, MO 65211.ORCID 0000-0002-1915-5892
Pao-Yang ChenInstitute of Plant and Microbial Biology, Academia Sinica, Taipei, Taiwan 11529.ORCID 0000-0002-7402-3075
Marjori MatzkeInstitute of Plant and Microbial Biology, Academia Sinica, Taipei, Taiwan 11529; marjorimatzke@gate.sinica.edu.tw antoniusmatzke@gate.sinica.edu.tw birchlerj@missouri.edu.
Antonius J M MatzkeInstitute of Plant and Microbial Biology, Academia Sinica, Taipei, Taiwan 11529; marjorimatzke@gate.sinica.edu.tw antoniusmatzke@gate.sinica.edu.tw birchlerj@missouri.edu.
Jianlin ChengDepartment of Electrical Engineering and Computer Science, University of Missouri, Columbia, MO 65211.
James A BirchlerDivision of Biological Sciences, University of Missouri, Columbia, MO 65211; marjorimatzke@gate.sinica.edu.tw antoniusmatzke@gate.sinica.edu.tw birchlerj@missouri.edu.
University of Missouri · USInstitute of Plant and Microbial Biology, Academia Sinica · TWDuy Tan University · VNMax Planck Institute for Plant Breeding Research · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Changes in dosage of part of the genome (aneuploidy) have long been known to produce much more severe phenotypic consequences than changes in the number of whole genomes (ploidy). To examine the basis of these differences, global gene expression in mature leaf tissue for all five trisomies and in diploids, triploids, and tetraploids of

Indexed as

AneuploidyAnimalsArabidopsisChromosomesChromosomes, PlantDNA MethylationDrosophilaGene ExpressionMicePolyploidyTrisomyYeastsaneuploidydosage compensationgene balance hypothesispolyploidytrisomy

Identifiers

PMID30429332
PMCPMC6275517
OpenAlexW2900900829

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.