Evidence map›Paper›PMID 30429329›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2018

DksA-DnaJ redox interactions provide a signal for the activation of bacterial RNA polymerase.

Ju-Sim Kim, Lin Liu, Liam F Fitzsimmons, Yang Wang, Matthew A Crawford, Mauricio Mastrogiovanni, Madia Trujillo, James Karl A Till, Rafael Radi, Shaodong Dai and 1 more

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
4.7field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 47 citations in OpenAlex.

  1. Review
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  7. Development of heat-shock resistance inApplied and environmental microbiology · 2023
    Article
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  11. International journal of molecular sciences · 2023
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  17. InJournal of bacteriology · 2022
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 2 countries.

Ju-Sim KimDepartment of Immunology & Microbiology, University of Colorado School of Medicine, Aurora, CO 80045.
Lin LiuDepartment of Immunology & Microbiology, University of Colorado School of Medicine, Aurora, CO 80045.
Liam F FitzsimmonsDepartment of Immunology & Microbiology, University of Colorado School of Medicine, Aurora, CO 80045.
Yang WangDepartment of Pharmaceutical Sciences, University of Colorado Skaags School of Pharmacy and Pharmaceutical Sciences, Aurora, CO 80045.
Matthew A CrawfordDepartment of Immunology & Microbiology, University of Colorado School of Medicine, Aurora, CO 80045.
Mauricio MastrogiovanniDepartamento de Bioquímica, Facultad de Medicina, Universidad de la República, 11800 Montevideo, Uruguay.
Madia TrujilloDepartamento de Bioquímica, Facultad de Medicina, Universidad de la República, 11800 Montevideo, Uruguay.
James Karl A TillDepartment of Immunology & Microbiology, University of Colorado School of Medicine, Aurora, CO 80045.
Rafael RadiDepartamento de Bioquímica, Facultad de Medicina, Universidad de la República, 11800 Montevideo, Uruguay; rradi@fmed.edu.uy Andres.Vazquez-Torres@ucdenver.edu.
Shaodong DaiDepartment of Immunology & Microbiology, University of Colorado School of Medicine, Aurora, CO 80045.
Andrés Vázquez-TorresDepartment of Immunology & Microbiology, University of Colorado School of Medicine, Aurora, CO 80045; rradi@fmed.edu.uy Andres.Vazquez-Torres@ucdenver.edu.
University of Colorado Denver · USUniversidad de la República · UY

Funding

Salmonella evasion of NADPH oxidase-dependent killingR01AI054959 · NIAID · UNIVERSITY OF COLORADO DENVER · PI VAZQUEZ-TORRES, ANDRES · 2003 to 2018
$5.2M
Molecular Mechanisms of Immune ToleranceT32AI074491 · NIAID · NATIONAL JEWISH HEALTH · PI CAMBIER, JOHN C, PELANDA, ROBERTA · 2009 to 2023
$4.1M
Molecular determinants of oxidative stress in Salmonella pathogenesisR01AI136520 · NIAID · UNIVERSITY OF COLORADO DENVER · PI Andres Vazquez-Torres · 2018 to 2026
$3.7M
Molecular Pathogenesis of Infectious DiseasesT32AI052066 · NIAID · UNIVERSITY OF COLORADO DENVER · PI VAN DYK, LINDA F. · 2002 to 2022
$2.3M
Molecular Basis of T Cell Recognition of Metal IonsR01ES025797 · NIEHS · UNIVERSITY OF COLORADO DENVER · PI DAI, SHAODONG · 2015 to 2019
$1.8M
Heavy Metal Induced AutoimmunityR21ES025885 · NIEHS · UNIVERSITY OF COLORADO DENVER · PI DAI, SHAODONG · 2017 to 2018
$432k
Analysis of intracellular host defenses in Salmonella pathogenesisR56AI054959 · NIAID · UNIVERSITY OF COLORADO DENVER · PI VAZQUEZ-TORRES, ANDRES · 2008 to 2008
$378k
Molecular study of DksA as a smart switch central to Salmonella pathogenesisF32AI108249 · NIAID · UNIVERSITY OF VIRGINIA · PI CRAWFORD, MATTHEW ANTHONY · 2014 to 2016
$155k
Regulation of Nucleotide Pools Mediates Recovery from Nitric Oxide-Induced Cytotoxicity in SalmonellaF31AI118223 · NIAID · UNIVERSITY OF COLORADO DENVER · PI FITZSIMMONS, LIAM FRY · 2016 to 2017
$62k
Molecular Analysis of Bacterial Adaptive Response to Host Reactive SpeciesI01BX002073 · VA · VA EASTERN COLORADO HEALTH CARE SYSTEM · PI Andres Vazquez-Torres · 2013 to 2026
–
BLRD VA I01 BX002073NIAID NIH HHS F31 AI118223NIAID NIH HHS F32 AI108249NIAID NIH HHS R01 AI054959NIAID NIH HHS R01 AI136520NIAID NIH HHS R56 AI054959NIAID NIH HHS T32 AI052066NIAID NIH HHS T32 AI074491NIEHS NIH HHS R01 ES025797NIEHS NIH HHS R21 ES025885
6 · The paper itself

Abstract

RNA polymerase is the only known protein partner of the transcriptional regulator DksA. Herein, we demonstrate that the chaperone DnaJ establishes direct, redox-based interactions with oxidized DksA. Cysteine residues in the zinc finger of DksA become oxidized in

Indexed as

AnimalsBacterial ProteinsDNA-Directed RNA PolymerasesEnzyme ActivationGenes, BacterialGuanosine TetraphosphateHSP40 Heat-Shock ProteinsHydrogen PeroxideMiceModels, MolecularOxidation-ReductionOxidative StressProtein Interaction Domains and MotifsRNA, BacterialSalmonellaSignal TransductionBacterial ProteinsDNA-Directed RNA PolymerasesGuanosine TetraphosphateHSP40 Heat-Shock ProteinsHydrogen PeroxideRNA, BacterialDnaJoxidationredox signalingSalmonellastringent response

Identifiers

PMID30429329
PMCPMC6294903
OpenAlexW2900524236

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.