ArticleJournal of the Royal Society, Interface2018
Cellular geometry controls the efficiency of motile sperm aggregates.
Article in Journal of the Royal Society, Interface, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Topological defects lead to energy transfer in active nematics.Nature communications · 2026Article
- Elucidating motion patterns in sperm cell motion with dynamic mode decomposition.Journal of biological physics · 2026Article
- Self-organized vortex phases and hydrodynamic interactions in Bos taurus sperm cells.Physical review. E · 2024Article
- Human sperm cooperate to transit highly viscous regions on the competitive pathway to fertilization.Communications biology · 2023Article
- Locomotion of bovine spermatozoa during the transition from individual cells to bundles.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Sperm bauplan and function and underlying processes of sperm formation and selection.Physiological reviews · 2022Review
- Bundle formation of sperm: Influence of environmental factors.Frontiers in endocrinology · 2022Article
- The social shape of sperm: using an integrative machine-learning approach to examine sperm ultrastructure and collective motility.Proceedings. Biological sciences · 2021Article
- Apical Sperm Hook Morphology Is Linked to Sperm Swimming Performance and Sperm Aggregation inCells · 2021Article
- Modelling Motility: The Mathematics of Spermatozoa.Frontiers in cell and developmental biology · 2021Review
- Collective dynamics of sperm cells.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2020Review
- Methodological considerations for examining the relationship between sperm morphology and motility.Molecular reproduction and development · 2020Review
- Postcopulatory sexual selection is associated with sperm aggregate quality inBehavioral ecology : official journal of the International Society for Behavioral EcologyArticle
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Sperm that swim collectively to the fertilization site have been observed across several vertebrate and invertebrate species, with groups ranging in size from sperm pairs to massive aggregates containing hundreds of cells. Although the molecular mechanisms that regulate sperm-sperm adhesion are still unclear, aggregation can enhance sperm motility and thus offer a fertilization advantage. Here, we report a thorough computational investigation on the role of cellular geometry in the performance of sperm aggregates. The sperm head is modelled as a persistent random walker characterized by a non-trivial three-dimensional shape and equipped with an adhesive region where cell-cell binding occurs. By considering both, a simple parametric head shape and a computer reconstruction of a real head shape based on morphometric data, we demonstrate that the geometry of the head and the structure of the adhesive region crucially affects both the stability and motility of the aggregates. Our analysis further suggests that the apical hook commonly found in the sperm of muroid rodents might serve to shield portions of the adhesive region and promote efficient alignment of the velocities of the interacting cells.
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