Evidence map›Paper›PMID 30429231›Full record

ArticleBioscience reports2018

Single-nucleotide polymorphism rs731384 is associated with plasma lipid levels and the risk of coronary artery disease in Chinese populations.

Chenhui Zhao, Mingyue Ji, Jing Zhang, Qiaowei Jia, Jieyin Liu, Fenghui An, Zhaohong Chen, Lihua Li, Liansheng Wang, Wenzhu Ma and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioscience reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Chenhui ZhaoDepartment of Cardiovascular Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, Jiangsu Province, China.
Mingyue JiDepartment of Cardiovascular Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, Jiangsu Province, China.
Jing ZhangDepartment of Cardiovascular Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, Jiangsu Province, China.
Qiaowei JiaDepartment of Cardiovascular Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, Jiangsu Province, China.
Jieyin LiuDepartment of Cardiovascular Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, Jiangsu Province, China.
Fenghui AnDepartment of Cardiovascular Medicine, The Friendship Hospital of Ili Kazakh Autonomous Prefecture, Yining 835000, China.
Zhaohong ChenDepartment of Cardiovascular Medicine, The Friendship Hospital of Ili Kazakh Autonomous Prefecture, Yining 835000, China.
Lihua LiDepartment of Cardiovascular Medicine, The Friendship Hospital of Ili Kazakh Autonomous Prefecture, Yining 835000, China.
Liansheng WangDepartment of Cardiovascular Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, Jiangsu Province, China.
Wenzhu MaDepartment of Cardiovascular Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, Jiangsu Province, China.
Zhijian YangDepartment of Cardiovascular Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, Jiangsu Province, China.
En-Zhi JiaDepartment of Cardiovascular Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, Jiangsu Province, China enzhijia@njmu.edu.cn.
Jiangsu Province Hospital · CNNanjing Medical University · CNYili Friendship Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimsTo investigate the relationship between the miR-130a polymorphism rs731384 and coronary artery disease (CAD) and to further explore the molecular mechanism of the pathogenesis of CAD, an observational single-center study was conducted.

methodA total of 876 subjects were recruited in the present study. Four milliliters of venous blood was drawn after 12 h of fasting to perform biochemical assays. CAD patients and controls were distinguished by coronary angiography. Rs731384 was genotyped on the Agena MassARRAY system according to the manufacturer's user guide. Statistical analysis was conducted using SPSS 16.0 software.

resultsThe study found that the plasma levels of total cholesterol (TC) (

conclusionThe mutant AA genotype of rs731384 seems to be a protective factor against CAD, and rs731384 plays an important role in the human metabolism of plasma lipids.

Indexed as

Genetic Predisposition to DiseaseAdultAllelesApolipoproteins AApolipoproteins BChinaCholesterol, HDLCholesterol, LDLCoronary Artery DiseaseFemaleGenetic Association StudiesGenotypeHumansLipidsMaleMicroRNAsApolipoproteins AApolipoproteins BCholesterol, HDLCholesterol, LDLLipidsMicroRNAsMIRN130 microRNA, humancoronary artery diseasemiR-130aSerum lipidSingle nucleotide polymorphism

Identifiers

PMID30429231
PMCPMC6435504
OpenAlexW2900758712

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.