Evidence map›Paper›PMID 30429227›Full record

ArticlemSphere2018

The Protective Role of

Yun Kyung Lee, Parpi Mehrabian, Silva Boyajian, Wei-Li Wu, Jane Selicha, Steven Vonderfecht, Sarkis K Mazmanian

Open access · goldAbstract read
In one paragraph

Article in mSphere, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 75 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
75citing papers in PubMed, 1 pooled it
4.3field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

75 citing papers in PubMed, 1 synthesis or guideline pooled it, 132 citations in OpenAlex.

  1. Pooled it
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  15. Identification of a secreted protease frombioRxiv : the preprint server for biology · 2025
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15 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 3 countries.

Yun Kyung LeeDivision of Biology & Biological Engineering, California Institute of Technology, Pasadena, California, USA yunklee@sch.ac.kr.
Parpi MehrabianDivision of Biology & Biological Engineering, California Institute of Technology, Pasadena, California, USA.
Silva BoyajianDivision of Biology & Biological Engineering, California Institute of Technology, Pasadena, California, USA.
Wei-Li WuDivision of Biology & Biological Engineering, California Institute of Technology, Pasadena, California, USA.
Jane SelichaDivision of Biology & Biological Engineering, California Institute of Technology, Pasadena, California, USA.
Steven VonderfechtCenter for Comparative Medicine, Beckman Research Institute, City of Hope, Duarte, California, USA.
Sarkis K MazmanianDivision of Biology & Biological Engineering, California Institute of Technology, Pasadena, California, USA.
California Institute of Technology · USBeckman Research InstituteNational Cheng Kung University · TWSoonchunhyang University · KR

Funding

Protection from Mucosal Pathology by Gut Microflora during Experimental ColitisR01DK078938 · NIDDK · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI MAZMANIAN, SARKIS K · 2009 to 2020
$5.1M
Protection from Mucosal Pathology by Gut Microbiota During Experimentas ColitisR56DK078938 · NIDDK · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI MAZMANIAN, SARKIS K · 2016 to 2016
$618k
NIDDK NIH HHS R01 DK078938NIDDK NIH HHS R56 DK078938
6 · The paper itself

Abstract

Many patients with chronic inflammation of the gut, such as that observed in inflammatory bowel disease (IBD), develop colorectal cancer (CRC). Recent studies have reported that the development of IBD and CRC partly results from an imbalanced composition of intestinal microbiota and that intestinal inflammation in these diseases can be modulated by the microbiota. The human commensal

Indexed as

AnimalsAzoxymethaneBacteroides fragilisColitisColonic NeoplasmsDextran SulfateDisease Models, AnimalMiceReceptors, CCR5AzoxymethaneCCR5 protein, mouseDextran SulfateReceptors, CCR5Bacteroides fragiliscolitis-associated colorectal cancerinflammationpolysaccharide AToll-like receptor 2

Identifiers

PMID30429227
PMCPMC6236802
OpenAlexW2901689633

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.