Evidence map›Paper›PMID 30429218›Full record

ArticleThe Journal of biological chemistry2019

Acyl-chain selectivity and physiological roles of

Maxime G Cuypers, Chitra Subramanian, Jessica M Gullett, Matthew W Frank, Stephen W White, Charles O Rock

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 38 citations in OpenAlex.

  1. Enhancement of low-temperature growth ofbioRxiv : the preprint server for biology · 2026
    Article
  2. Article
  3. High-quality genome assembly ofMicrobiology resource announcements · 2025
    Article
  4. Article
  5. Review
  6. Article
  7. Bacterial acquisition of host fatty acids has far-reaching implications on virulence.Microbiology and molecular biology reviews : MMBR · 2024
    Review
  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Lipid and fatty acid metabolism in trypanosomatids.Microbial cell (Graz, Austria) · 2021
    Review
  17. Article
  18. Proceedings of the National Academy of Sciences of the United States of America · 2021
    Article
  19. Frontiers in microbiology · 2021
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Maxime G CuypersDepartment of Structural Biology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105.
Chitra SubramanianDepartment of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee 38105.
Jessica M GullettDepartment of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee 38105.
Matthew W FrankDepartment of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee 38105.
Stephen W WhiteDepartment of Structural Biology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105.
Charles O RockDepartment of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee 38105. Electronic address: charles.rock@stjude.org.
St. Jude Children's Research Hospital · US

Funding

Viral Vector Technology (VVTSR)P30CA021765 · NCI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI CHARLES ROBERTS · 1985 to 2026
$166.9M
REGULATION OF LIPID METABOLISM IN E COLIR01GM034496 · NIGMS · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI ROCK, CHARLES O · 1985 to 2022
$9.2M
REGULATION OF LIPID METABOLISM IN BACTERIAR37GM034496 · NIGMS · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI ROCK, CHARLES O · 2001 to 2010
$5.7M
NCI NIH HHS P30 CA021765NIGMS NIH HHS R01 GM034496NIGMS NIH HHS R37 GM034496
6 · The paper itself

Abstract

Fatty acid (FA) kinase produces acyl-phosphate for the synthesis of membrane phospholipids in Gram-positive bacterial pathogens. FA kinase consists of a kinase protein (FakA) that phosphorylates an FA substrate bound to a second module, an FA-binding protein (FakB).

Indexed as

Bacterial ProteinsFatty Acid-Binding ProteinsOleic AcidStaphylococcus aureusSubstrate SpecificityBacterial ProteinsFatty Acid-Binding ProteinsOleic Acidacyl-phosphatefatty acid binding proteinfatty acid kinasefatty acid metabolismmembrane lipidmembrane phospholipidnutrient acquisitionStaphylococcus aureus (S. aureus)X-ray crystallography

Identifiers

PMID30429218
PMCPMC6322867
OpenAlexW2900524446

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.