Evidence map›Paper›PMID 30429216›Full record

ArticleThe Journal of biological chemistry2019

Neuraminidase 1-mediated desialylation of the mucin 1 ectodomain releases a decoy receptor that protects against

Erik P Lillehoj, Wei Guang, Sang W Hyun, Anguo Liu, Nicolas Hegerle, Raphael Simon, Alan S Cross, Hideharu Ishida, Irina G Luzina, Sergei P Atamas and 1 more

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. MUC1 in the upper-lower airway inflammatory continuum: an endotype-centered perspective.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2025
    Review
  4. iScience · 2024
    Article
  5. Review
  6. Article
  7. Review
  8. Review
  9. Sialidase Inhibitors with Different Mechanisms.Journal of medicinal chemistry · 2022
    Review
  10. Article
  11. [Biofilm Eradication Four-Step Strategy: Study of Using Self-Assembled Azithromycin/Rhamnolipid Nanoparticles for RemovingSichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2021
    Article
  12. Decoy Technology as a Promising Therapeutic Tool for Atherosclerosis.International journal of molecular sciences · 2021
    Review
  13. Article
  14. Review
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 2 countries.

Erik P LillehojFrom the Departments of Pediatrics, elillehoj@som.umaryland.edu.
Wei GuangFrom the Departments of Pediatrics.
Sang W HyunMedicine, and.
Anguo LiuMedicine, and.
Nicolas HegerleMedicine, and.
Raphael SimonMedicine, and.
Alan S CrossMedicine, and.
Hideharu IshidaDepartment of Applied Bio-organic Chemistry, Gifu University, Gifu 501-1193 Japan.
Irina G LuzinaMedicine, and.
Sergei P AtamasMedicine, and.
Simeon E GoldblumMedicine, and.
University of Maryland, Baltimore · USVeterans Health Administration · USUnited States Department of Veterans Affairs · USGifu University · JPPediatrics and Genetics · US

Funding

Role of Sialidase in Pulmonary Host Defenses and Acute Lung InjuryR01HL086933 · NHLBI · UNIVERSITY OF MARYLAND BALTIMORE · PI CROSS, ALAN S. · 2007 to 2010
$1.8M
EXPLORATION OF PROTECTIVE IMMUNITY INDUCED BY SALMONELLA COPS: FLIC CONJUGATESR01AI110627 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI TENNANT, SHARON MEI · 2014 to 2017
$1.5M
The Mechanisms of Profibrotic Sensitization by IL33R01HL126897 · NHLBI · UNIVERSITY OF MARYLAND BALTIMORE · PI LUZINA, IRINA G. · 2015 to 2018
$1.4M
Cryo Upgrade of UMB EM Core FacilityS10RR026870 · NCRR · UNIVERSITY OF MARYLAND BALTIMORE · PI HSIA, RU-CHING · 2010 to 2010
$421k
NEU1 Sialidase Disrupts CD31-Driven Angiogenesis in Human Lung EndotheliaI01BX002352 · VA · BALTIMORE VA MEDICAL CENTER · PI GOLDBLUM, SIMEON EMANUEL · 2015 to 2018
–
BLRD VA I01 BX002352NCRR NIH HHS S10 RR026870NHLBI NIH HHS R01 HL086933NHLBI NIH HHS R01 HL126897NIAID NIH HHS R01 AI110627
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AnimalsFemaleFlagellinHost-Pathogen InteractionsHumansLungMaleMice, Inbred BALB CMucin-1NeuraminidasePneumonia, BacterialProtective FactorsPseudomonas aeruginosaPseudomonas InfectionsFlagellinMucin-1Neu1 protein, mouseNeuraminidaseadhesincell surface associated (MUC1)decoy proteinflagellinmucin 1neuraminidasePseudomonas aeruginosa (P. aeruginosa)sialic acidsialidasevirulence

Identifiers

PMID30429216
PMCPMC6333888
OpenAlexW2901664219

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.