Evidence map›Paper›PMID 30429194›Full record

ArticleCanadian family physician Medecin de famille canadien2018

Antidepressant and antipsychotic prescribing in primary care for people with dementia.

Neil Drummond, Lynn McCleary, Elizabeth Freiheit, Frank Molnar, William Dalziel, Carole Cohen, Diana Turner, Rebecca Miyagishima, James Silvius

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In one paragraph

Article in Canadian family physician Medecin de famille canadien, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Neil DrummondProfessor and holds the Alberta Health Services Chair in Primary Care Research in the Department of Family Medicine at the University of Alberta in Calgary. ndrummon@ualberta.ca.
Lynn McClearyAssociate Professor in the Department of Nursing at Brock University in St Catharines, Ont.
Elizabeth FreiheitManaging Director in the Statistical Analysis of Biomedical and Educational Research unit in the Department of Biostatistics at the University of Michigan School of Public Health in Ann Arbor.
Frank MolnarSpecialist in geriatric medicine practising in Ottawa, Ont.
William DalzielProfessor of Geriatric Medicine in the Department of Medicine at the University of Ottawa.
Carole CohenClinical Director of the Psychiatric Services for the Elderly at Sunnybrook Health Sciences Centre in Toronto, Ont.
Diana TurnerMedical Director of Carewest of Alberta Health Services.
Rebecca MiyagishimaResearch Coordinator in the Department of Family Medicine at the University of Alberta in Edmonton.
James SilviusClinical Associatie Professor in the Cumming School of Medicine at the University of Calgary.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo use data from the Canadian Primary Care Sentinel Surveillance Network (CPCSSN) to evaluate the prevalence of antidepressant and antipsychotic prescriptions among patients with no previous depression or psychosis diagnoses, and to identify the factors associated with the use of these drugs in this population.

designRetrospective cohort study using data derived from CPCSSN.

settingPrimary care practices associated with CPCSSN.

participantsPatients who were born before 1949; who were associated with a CPCSSN primary care practitioner between October 1, 2007, and September 30, 2013; and whose electronic medical records contained data from at least 6 months before and 12 months after the date of dementia diagnosis.

main outcome measuresPrescription for an antidepressant or antipsychotic medication in the absence of a depression or psychosis diagnosis. Multivariable models were fitted to determine estimated odds ratios (ORs) and were adjusted for age and sex.

resultsOf the 3252 patients without a depression diagnosis, 8.5% received a new prescription for an antidepressant in the 12 months following their diagnosis of dementia. Prescribing was reduced in association with older age (OR of 0.86 per 5-year age increase,

conclusionA substantial number of patients with dementia are being prescribed antidepressant or antipsychotic medications by their primary care practitioners without evidence of depression or psychosis in their electronic medical records.

Indexed as

AgedAged, 80 and overAntidepressive AgentsAntipsychotic AgentsCanadaDatabases, FactualDementiaDepressive DisorderDrug PrescriptionsFemaleHumansMaleMultivariate AnalysisOdds RatioPrimary Health CarePsychotic DisordersAntidepressive AgentsAntipsychotic Agents

Identifiers

PMID30429194
PMCPMC6234938

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.