Trial reportTrials2018
Recruitment of patients with de novo Parkinson disease: successful strategies in a randomized exercise clinical trial.
Trial report in Trials, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01506479 (Exploratory Study of Different Doses of Endurance Exercise in People With Parkinson Disease), which is not on this map. Cited by 10 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Exploratory Study of Different Doses of Endurance Exercise in People With Parkinson Disease
Who cites it
10 citing papers in PubMed, 2 syntheses or guidelines pooled it, 13 citations in OpenAlex.
- Physical exercise for people with Parkinson's disease: a systematic review and network meta-analysis.The Cochrane database of systematic reviews · 2024Pooled it
- Physical exercise for people with Parkinson's disease: a systematic review and network meta-analysis.The Cochrane database of systematic reviews · 2023Pooled it
- Differential Temporal Perception Abilities in Parkinson's Disease Patients Based on Timing Magnitude.Scientific reports · 2019Trial
- Interventions for promoting physical activity in people with newly diagnosed Parkinson's disease: scoping review.Systematic reviews · 2025Article
- Taxonomy of chronic illness research recruitment: a restricted scoping review.BMC health services research · 2025Article
- Diffusion tensor metrics, motor and non-motor symptoms in de novo Parkinson's disease.Neuroradiology · 2024Article
- Rapid Metabolic Profiling of 1 μL Crude Cerebrospinal Fluid by Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry Imaging Can DifferentiateAnalytical chemistry · 2023Article
- Does MDS-UPDRS Provide Greater Sensitivity to Mild Disease than UPDRS in De Novo Parkinson's Disease?Movement disorders clinical practice · 2021Article
- Barriers to Participation in Therapeutic Clinical Trials as Perceived by Community Oncologists.JCO oncology practice · 2020Article
- "I Want to Do It, But I Want to Make Sure That I Do It Right." Views of Patients with Parkinson's Disease Regarding Early Stem Cell Clinical Trial Participation.AJOB empirical bioethicsArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
introductionRecruitment of sufficient patients with Parkinson disease into clinical trials is a barrier to successful, timely study completion. Non-pharmacologic studies have shown to be even more challenging for recruitment, despite some studies focusing on de novo Parkinson disease populations. This paper describes successful recruitment techniques from a randomized exercise clinical trial in Parkinson disease.
methodsSeveral recruitment strategies were used to enroll de novo patients with Parkinson disease into a year-long clinical trial. Strategies focused on infrastructure included fast-track clinic scheduling, weekly research meetings, an established clinical repository, real-time clinic recruitment, and outreach to the community. The nature of the study facilitated recruitment by offering a wait-listed control group, exercise at a local fitness center with a paid membership, and collection of data by shipping equipment foregoing some visits. An experienced nurse study coordinator involved in recruitment and training of the principal investigator in recruitment of minorities enhanced overall recruitment. Finally, the patient population chosen for this study, patients with de novo Parkinson disease, may be more likely to enroll in an exercise study than patients with later stage disease.
resultsSeventy-six patients with de novo Parkinson disease were successfully enrolled into the exercise clinical trial from a single site.
conclusionTargeted recruitment strategies were successful in this study. Additional modifications to the study protocol, such as eliminating treadmill stress tests before randomization, travel to an urban downtown location for study visits, and a relatively healthy Parkinson disease population, may also have impacted this study. These strategies could all be adopted for other studies in Parkinson disease, neurodegenerative diseases, or other chronic disorders.
trial registrationClinicaltrials.gov, NCT01506479 . Registered on 10 January 2012.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.