Evidence map›Paper›PMID 30428875›Full record

ArticleJournal of nanobiotechnology2018

A novel microemulsion-based isotonic perfusate modulated by Ringer's solution for improved microdialysis recovery of liposoluble substances.

Yong-Tai Zhang, Zhi Wang, Li-Na Shen, Yan-Yan Li, Ze-Hui He, Qing Xia, Nian-Ping Feng

Open access · goldAbstract read
In one paragraph

Article in Journal of nanobiotechnology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Yong-Tai ZhangDepartment of Pharmaceutical Sciences, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, People's Republic of China.
Zhi WangDepartment of Pharmaceutical Sciences, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, People's Republic of China.
Li-Na ShenDepartment of Pharmaceutical Sciences, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, People's Republic of China.
Yan-Yan LiDepartment of Pharmaceutical Sciences, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, People's Republic of China.
Ze-Hui HeDepartment of Pharmaceutical Sciences, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, People's Republic of China.
Qing XiaDepartment of Pharmaceutical Sciences, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, People's Republic of China.
Nian-Ping FengDepartment of Pharmaceutical Sciences, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, People's Republic of China. npfeng@hotmail.com.
Shanghai University of Traditional Chinese Medicine · CN

Funding

National Natural Science Fundation of China 81673612
6 · The paper itself

Abstract

backgroundMicrodialysis is promising technique for dynamic microbiochemical sampling from tissues. However, the application of typical aqueous perfusates to liposoluble substances is limited. In this study, a novel microemulsion (ME)-based isotonic perfusate (RS-ME) was prepared to improve the recovery of liposoluble components using microdialysis probes.

resultsBased on pseudo-ternary phase diagrams and comparisons of the ME area, Kolliphor

conclusionsOwing to the nanosized droplets formed by lipid components in the RS-ME and the limited dispersion out of the dialysis membrane, we obtained good biocompatibility and reliable dialysis results, without affecting the tissue microenvironment. As a novel perfusate, RS-ME provides an easy and reliable approach to the microdialysis sampling of fat-soluble components.

Indexed as

AnimalsDrug CarriersEmulsionsFibroblastsHumansIsotonic SolutionsLipidsMaleMembranes, ArtificialMicrodialysisNanoparticlesOleic AcidsParticle SizePerfusionPolyethylene GlycolsQuinazolinesDrug CarriersEmulsionsethyl oleateevodiamineIsotonic SolutionsLipidsMembranes, ArtificialOleic Acidspolyethylene glycol 400Polyethylene GlycolsQuinazolinesRinger's SolutionRutheniumSurface-Active AgentsBiocompatibilityMicrodialysisMicroemulsionNanocarrierSolubilization

Identifiers

PMID30428875
PMCPMC6237007
OpenAlexW2900832819

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.