ArticleBMC nephrology2018
Serum levels of tumor necrosis factor alpha in patients with IgA nephropathy are closely associated with disease severity.
Article in BMC nephrology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.
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Who cites it
33 citing papers in PubMed, 1 synthesis or guideline pooled it, 60 citations in OpenAlex.
- Impact of tumor necrosis factor-alpha gene variant in pediatric nephrotic syndrome: a meta-analysis.Scientific reports · 2025Pooled it
- Effect of Fish-Derived Lipids on Inflammation Status and Health-Related Quality of Life in Women with Endometriosis.Nutrients · 2026Trial
- Pro-inflammatory biomarkers associated with depression severity among adults with HIV in New York City.Journal of psychiatric research · 2025Trial
- The effect of an orally-dosed Gynostemma pentaphyllum extract (ActivAMP®) on body composition in overweight, adult men and women: A double-blind, randomised, placebo-controlled study.Journal of human nutrition and dietetics : the official journal of the British Dietetic Association · 2022Trial
- Effect of pentoxifylline on inflammatory markers in non-diabetic chronic kidney disease patients: A prospective, interventional, open label.World journal of nephrology · 2026Article
- PMEnvironment & health (Washington, D.C.) · 2026Article
- Article
- Similar Individual Serum Levels of MCP-1, TNF-α, and IL-6 From Periodontitis Patients Before and 1 Year After Treatment.Scandinavian journal of immunology · 2026Article
- Multiple circulating inflammatory proteins are associated with pathological lesions and kidney function decline in IgA nephropathy.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2025Article
- Profile of serum levels of TNF-α, IL-1β, IL-6, IL-8, IL-12, adiponectin, and vitamin DClinical and experimental hepatology · 2025Article
- New and Emerging Biomarkers in Chronic Kidney Disease.Biomedicines · 2025Review
- Dental amalgam associated with SAPHO syndrome and IgA nephropathy: a case report and literature review.BMC nephrology · 2025Review
- Effect of a polyphenol-rich dietary pattern on subjects aged ≥ 60 years with higher levels of inflammatory markers: insights into microbiome and metabolome.Microbiome research reports · 2025Article
- Identification of inflammatory biomarkers in IgA nephropathy using the NanoString technology: a validation study in Caucasians.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2024Article
- Serum tumor necrosis factor-alpha status in hospitalized patients with coronavirus disease-2019 (COVID-19).Caspian journal of internal medicine · 2024Article
- Duration-sensitive association between air pollution exposure and changes in cardiometabolic biomarkers: Evidence from a predominantly African American cohort.Environmental research · 2024Article
- IgA nephropathy associated with Crohn's disease.World journal of methodology · 2023Review
- Specific S100 Proteins Bind Tumor Necrosis Factor and Inhibit Its Activity.International journal of molecular sciences · 2022Article
- Crohn's disease may promote inflammation in IgA nephropathy: a case-control study of patients undergoing kidney biopsy.Virchows Archiv : an international journal of pathology · 2022Article
- No increase in inflammation in late-life major depression screened to exclude physical illness.Translational psychiatry · 2022Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTumor necrosis factor alpha (TNF-α) is considered to play an important role in the pathogenesis in IgA nephropathy (IgAN). The correlations between serum TNF-α and disease severity in patients with IgAN remain controversial.
methodsConcentrations of serum TNF-α of 147 patients with IgAN and 126 healthy subjects were measured by chemiluminescence immunoassay. Correlations with clinicopathological features of patients with IgAN were evaluated.
resultsSerum levels of TNF-α [9.20 (7.70-10.60) pg/mL vs. 6.04 (5.11-7.23) pg/mL, P < 0.0001] were higher in patients with IgAN than that in healthy subjects. Receiver operating characteristic curve analysis revealed that TNF-α had better discrimination between patients with IgAN and healthy controls than estimated glomerular filtration rate [TNF-α: (AUC, 0.87; 95% CI, 0.83-0.91; P < 0.0001) vs. estimated glomerular filtration rate: (AUC, 0.76; 95% CI, 0.71-0.82; P < 0.0001), P = 0.007]. Multivariate linear regression analyses showed that serum levels of TNF-α were positively correlated with 24-h urine protein excretion (r = 0.33, P = 0.04), urinary protein to serum creatinine ratio (r = 0.33, P = 0.03), serum creatinine (r = 0.46, P < 0.0001) and Cystatin C (r = 0.59, P < 0.0001) in IgAN and negatively correlated with estimated glomerular filtration rate (r = - 0.49, P < 0.0001) after adjustment for sex, systolic blood pressure and diastolic blood pressure. Patients with higher mesangial hypercellularity or tubular atrophy/interstitial fibrosis score according to Oxford classification showed higher serum levels of TNF-α.
conclusionsOur data showed that serum levels of TNF-α detected by chemiluminescence immunoassay was a potential biomarker for evaluating the disease severity in IgAN.
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