Evidence map›Paper›PMID 30428613›Full record

ReviewMedicines (Basel, Switzerland)2018

The Biological Efficacy of Natural Products against Acute and Chronic Inflammatory Diseases in the Oral Region.

Toshiaki Ara, Sachie Nakatani, Kenji Kobata, Norio Sogawa, Chiharu Sogawa

Open access · goldAbstract readReview
In one paragraph

Review in Medicines (Basel, Switzerland), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
3.2field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 34 citations in OpenAlex.

  1. [Research Advances on Natural Products in Maintaining Oral Microecological Balance].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2026
    Review
  2. Review
  3. Article
  4. Article
  5. Pharmacological Activity of Cepharanthine.Molecules (Basel, Switzerland) · 2023
    Review
  6. Article
  7. Pharmaceuticals (Basel, Switzerland) · 2022
    Article
  8. Article
  9. Article
  10. Article
  11. Plants as Sources of Anti-Inflammatory Agents.Molecules (Basel, Switzerland) · 2020
    Review
  12. Review
  13. Antimicrobial Activity ofJournal of pharmacy & bioallied sciences · 2019
    Article
  14. Article
  15. Effects of shokyo (PeerJ · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Toshiaki AraDepartment of Dental Pharmacology, Matsumoto Dental University, 1780 Gobara Hirooka, Shiojiri 399-0781, Japan. toshiaki.ara@mdu.ac.jp.ORCID 0000-0003-4005-9122
Sachie NakataniFaculty of Pharmacy and Pharmaceutical Sciences, Josai University, 1-1 Keyakidai, Sakado, Saitama 350-0295, Japan. s-nakata@josai.ac.jp.
Kenji KobataFaculty of Pharmacy and Pharmaceutical Sciences, Josai University, 1-1 Keyakidai, Sakado, Saitama 350-0295, Japan. kobata@josai.ac.jp.
Norio SogawaDepartment of Dental Pharmacology, Matsumoto Dental University, 1780 Gobara Hirooka, Shiojiri 399-0781, Japan. norio.sogawa@mdu.ac.jp.
Chiharu SogawaDepartment of Dental Pharmacology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Okayama 700-8525, Japan. caoki@md.okayama-u.ac.jp.ORCID 0000-0002-5606-0710
Josai University · JPMatsumoto Dental University · JPOkayama University · JP

Funding

JSPS KAKENHI JP16H05144
6 · The paper itself

Abstract

The oral inflammatory diseases are divided into two types: acute and chronic inflammatory diseases. In this review, we summarize the biological efficacy of herbal medicine, natural products, and their active ingredients against acute and chronic inflammatory diseases in the oral region, especially stomatitis and periodontitis. We review the effects of herbal medicines and a biscoclaurin alkaloid preparation, cepharamthin, as a therapy against stomatitis, an acute inflammatory disease. We also summarize the effects of herbal medicines and natural products against periodontitis, a chronic inflammatory disease, and one of its clinical conditions, alveolar bone resorption. Recent studies show that several herbal medicines such as kakkonto and ninjinto reduce LPS-induced PGE 2 production by human gingival fibroblasts. Among herbs constituting these herbal medicines, shokyo (

Indexed as

anti-osteoclast activityarachidonic acid cascadecepharanthinherbal medicineinflammatory diseasenatural productperiodontitisstomatitis

Identifiers

PMID30428613
PMCPMC6313758
OpenAlexW2900672060

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.