SynthesisInternational journal of molecular sciences2018
Potential Causes of Titanium Particle and Ion Release in Implant Dentistry: A Systematic Review.
Synthesis in International journal of molecular sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 89 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
89 citing papers in PubMed, 2 syntheses or guidelines pooled it, 212 citations in OpenAlex.
- Is titanium alloy Ti-6Al-4 V cytotoxic to gingival fibroblasts-A systematic review.Clinical and experimental dental research · 2021Pooled it
- Cytotoxic effects of submicron- and nano-scale titanium debris released from dental implants: an integrative review.Clinical oral investigations · 2021Pooled it
- A Randomised Controlled Trial Comparing a One-Piece Zirconia Tissue-Level Implant and Two-Piece Titanium Bone-Level Implant for Maxillary Single Tooth Replacement-3 year Results.Clinical oral implants research · 2026Trial
- The microbiome of dental and peri-implant subgingival plaque during peri-implant mucositis therapy: A randomized clinical trial.Journal of clinical periodontology · 2022Trial
- Oxidized-Lipid Signaling and Ferroptosis as Downstream Mechanisms of Titanium-Associated Peri-Implant Bone Loss.Antioxidants (Basel, Switzerland) · 2026Review
- Influence of cement composition and scaler selection on dental cement removal and surface damage.Odontology · 2026Article
- Detection of submicron titanium debris associated with peri-implantitis.Discover nano · 2026Review
- Cleansability of zirconia implants after exposure to different contamination media: a methodological assessment.Scientific reports · 2026Article
- Simulated Body Fluids for Dental Implant Corrosion: A Practical Guide.Dentistry journal · 2026Review
- Review
- Titanium migration and bone response in loaded osseointegrated implants: ESEM-EDX analysis in Macaca fascicularis.Journal of periodontology · 2026Article
- Analysis of Salivary Levels of Titanium and Nickel Levels among Patients Treated with Dental Implants Therapy.Journal of pharmacy & bioallied sciences · 2026Article
- Oral-fluid inflammatory and oxidative-stress biomarkers for peri-implantitis in Asian adults: a systematic review and stratified random-effects meta-analysis.Open life sciences · 2026Article
- Release of Titanium Particles After Implantoplasty in the Treatment of Peri-Implantitis: Local and Systemic Implications-An Integrative Systematic Review.Journal of clinical medicine · 2025Review
- Salivary Titanium Level as a Non-invasive Biomarker for Peri-Implantitis: A Prospective Study.Cureus · 2025Article
- Critical Questions Surrounding the Shot-Blasting Treatment of Titanium Dental Implants.Materials (Basel, Switzerland) · 2025Review
- Towards Enhanced Osteointegration: A Comparative and In-Depth Study of the Biocompatibility of an Innovative Calcium-Doped Zirconia Coating for Biomedical Implants.Journal of functional biomaterials · 2025Article
- Comparative analysis of gingival crevicular fluid and peri-implant crevicular fluid by mid-infrared spectroscopy: a split mouth study.Clinical oral investigations · 2025Article
- Comparative Evaluation of Corrosion Resistance of AISI 316L and Ti6Al4V Dental Materials Under Simulated Inflammatory Conditions.Materials (Basel, Switzerland) · 2025Article
- Antibacterial potential of silver and zinc loaded plasma-electrolytic oxidation coatings for dental titanium implants.International journal of implant dentistry · 2025Article
29 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Implant surface characteristics, as well as physical and mechanical properties, are responsible for the positive interaction between the dental implant, the bone and the surrounding soft tissues. Unfortunately, the dental implant surface does not remain unaltered and changes over time during the life of the implant. If changes occur at the implant surface, mucositis and peri-implantitis processes could be initiated; implant osseointegration might be disrupted and bone resorption phenomena (osteolysis) may lead to implant loss. This systematic review compiled the information related to the potential sources of titanium particle and ions in implant dentistry. Research questions were structured in the Population, Intervention, Comparison, Outcome (PICO) framework. PICO questionnaires were developed and an exhaustive search was performed for all the relevant studies published between 1980 and 2018 involving titanium particles and ions related to implant dentistry procedures. Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines were followed for the selection and inclusion of the manuscripts in this review. Titanium particle and ions are released during the implant bed preparation, during the implant insertion and during the implant decontamination. In addition, the implant surfaces and restorations are exposed to the saliva, bacteria and chemicals that can potentially dissolve the titanium oxide layer and, therefore, corrosion cycles can be initiated. Mechanical factors, the micro-gap and fluorides can also influence the proportion of metal particles and ions released from implants and restorations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.