Evidence map›Paper›PMID 30428465›Full record

ArticleAmerican journal of nephrology2018

Association of Abdominal Adiposity with Cardiovascular Mortality in Incident Hemodialysis.

Jessica Fitzpatrick, Stephen M Sozio, Bernard G Jaar, Mara A McAdams-DeMarco, Michelle M Estrella, Larisa G Tereshchenko, Jose M Monroy-Trujillo, Rulan S Parekh

Abstract readEvaluation Study
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of nephrology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
0.3field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.

  1. Pooled it
  2. Anthropometric Measures of Adiposity as Markers of Kidney Dysfunction: A Cross-Sectional Study.High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension · 2023
    Article
  3. Article
  4. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 6 institutions in 2 countries.

Jessica FitzpatrickChild Health Evaluative Sciences, Research Institute, The Hospital for Sick Children, Toronto, Ontario, Canada.
Stephen M SozioDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Bernard G JaarDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Mara A McAdams-DeMarcoWelch Center for Prevention, Epidemiology, and Clinical Research, Baltimore, Maryland, USA.
Michelle M EstrellaKidney Health Research Collaborative, Department of Medicine, University of California, San Francisco and Department of Medicine, San Francisco VA Medical Center, San Francisco, California, USA.
Larisa G TereshchenkoKnight Cardiovascular Institute, Oregon Health and Science University, Portland, Ontario, USA.
Jose M Monroy-TrujilloDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Rulan S ParekhChild Health Evaluative Sciences, Research Institute, The Hospital for Sick Children, Toronto, Ontario, Canada, rulan.parekh@sickkids.ca.
Johns Hopkins University · USInstitute for Clinical Evaluative Sciences · CAJohns Hopkins Medicine · USOregon Health & Science University · USUniversity of California, San Francisco · USWelch Foundation · US

Funding

Technological Assessment and Solutions Core - RC4P30AG021334 · NIA · JOHNS HOPKINS UNIVERSITY · PI Jeremy D Walston · 2003 to 2026
$33.2M
Kidney transplantation in older, frail and cognitively impaired adults with ESRD: Balancing utility vs. justiceR01AG055781 · NIA · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI MCADAMS DEMARCO, MARA A. · 2017 to 2021
$4.2M
Longitudinal Study of DialysisR01DK072367 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI PAREKH, RULAN S · 2007 to 2011
$3.7M
Novel ECG Measures and Risk of Sudden Cardiac DeathR01HL118277 · NHLBI · OREGON HEALTH & SCIENCE UNIVERSITY · PI TERESHCHENKO, LARISA GENNADIEVNA · 2013 to 2016
$1.5M
Frailty and Adverse Health Outcomes of Aging in Older Adults with Kidney FailureK01AG043501 · NIA · JOHNS HOPKINS UNIVERSITY · PI MCADAMS DEMARCO, MARA A. · 2014 to 2018
$624k
NIA NIH HHS K01 AG043501NIA NIH HHS P30 AG021334NIA NIH HHS R01 AG055781NIDDK NIH HHS R01 DK072367
6 · The paper itself

Abstract

backgroundThe risk of cardiovascular mortality is high among adults with end-stage renal disease (ESRD) undergoing hemodialysis. Waist-to-hip ratio (WHR), a metric of abdominal adiposity, is a predictor of cardiovascular disease (CVD) and mortality in the general population; however, no studies have examined the association with CVD mortality, particularly sudden cardiac death (SCD), in incident hemodialysis.

methodsAmong 379 participants incident (< 6 months) to hemodialysis enrolled in the Predictors of Arrhythmic and Cardiovascular Risk in ESRD study, we evaluated associations between WHR and risk of CVD mortality, SCD, and non-CVD mortality in Cox proportional hazards regression models.

resultsAt study enrollment, mean age was 55 years with 41% females, 73% African Americans, and 57% diabetics. Mean body mass index was 29.3 kg/m2, and mean WHR was 0.95. During a median follow-up time of 2.5 years, there were 35 CVD deaths, 15 SCDs, and 48 non-CVD deaths. Every 0.1 increase in WHR was associated with higher risk (hazard ratio [95% CI]) of CVD mortality (1.75 [1.06-2.86]) and SCD (2.45 [1.20-5.02]), but not non-CVD mortality (0.93 [0.59-1.45]), independently of demographics, body mass index, comorbidities, inflammation, and traditional CVD risk factors.

conclusionsWHR is significantly associated with CVD mortality including SCD, independently of other CVD risk factors in incident hemodialysis. This simple, easily obtained bedside metric may be useful in dialysis patients for CVD risk stratification.

Indexed as

AdiposityAdultAgedBody Mass IndexCause of DeathDeath, Sudden, CardiacFemaleFollow-Up StudiesHumansKidney Failure, ChronicMaleMiddle AgedObesityProspective StudiesRenal DialysisRisk AssessmentAbdominal adiposityEnd stage renal diseaseMortalitySudden cardiac deathWaist-to-hip ratio

Identifiers

PMID30428465
PMCPMC6510390
OpenAlexW2900863454

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.