ArticleStem cell reports2018
Intestinal Stem Cells Exhibit Conditional Circadian Clock Function.
Article in Stem cell reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 48 citations in OpenAlex.
- Chrono-atlas of cell-type specific daily gene expression rhythms in the regenerating colon.Nature communications · 2026Article
- Bidirectional regulation between circadian feeding behavior and specialized midgut clocks inbioRxiv : the preprint server for biology · 2026Article
- The circadian-microbiome-immune axis in colorectal cancer: mechanisms of spatiotemporal immunosuppression and chronotherapeutic horizons.Frontiers in immunology · 2026Review
- Crosstalk between the circadian clock, intestinal stem cell niche, and epithelial cell fate decision.Genes & diseases · 2025Review
- The mutual impacts of stem cells and sleep: opportunities for improved stem cell therapy.Stem cell research & therapy · 2025Review
- Disruption of the intestinal clock drives dysbiosis and impaired barrier function in colorectal cancer.Science advances · 2024Article
- Review
- The circadian clock protein Cryptochrome 1 is a direct target and feedback regulator of the Hippo pathway.iScience · 2023Article
- Adult and Larval Tracheal Systems Exhibit Different Molecular Architectures inInternational journal of molecular sciences · 2023Article
- Circadian Clock Dysregulation and Prostate Cancer: A Molecular and Clinical Overview.Clinical Medicine Insights. Oncology · 2023Review
- Circadian clocks in health and disease: Dissecting the roles of the biological pacemaker in cancer.F1000Research · 2023Review
- Article
- Disruption of the circadian clock drivesScience advances · 2022Article
- Article
- Diurnal Interplay between Epithelium Physiology and Gut Microbiota as a Metronome for Orchestrating Immune and Metabolic Homeostasis.Metabolites · 2022Review
- Nutrient Sensing via Gut inInternational journal of molecular sciences · 2022Review
- Roles of peripheral clocks: lessons from the fly.FEBS letters · 2022Review
- Central and Peripheral Clock Control of Circadian Feeding Rhythms.Journal of biological rhythms · 2021Article
- The Circadian Clock Gene, Bmal1, Regulates Intestinal Stem Cell Signaling and Represses Tumor Initiation.Cellular and molecular gastroenterology and hepatology · 2021Article
- Extensive tissue-specific expression variation and novel regulators underlying circadian behavior.Science advances · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
The circadian clock is a molecular pacemaker that produces 24-hr physiological cycles known as circadian rhythms. How the clock regulates stem cells is an emerging area of research with many outstanding questions. We tested clock function in vivo at the single cell resolution in the Drosophila intestine, a tissue that is exquisitely sensitive to environmental cues and has circadian rhythms in regeneration. Our results indicate that circadian clocks function in intestinal stem cells and enterocytes but are downregulated during enteroendocrine cell differentiation. Drosophila intestinal cells are principally synchronized by the photoperiod, but intestinal stem cell clocks are highly responsive to signaling pathways that comprise their niche, and we find that the Wnt and Hippo signaling pathways positively regulate stem cell circadian clock function. These data reveal that intestinal stem cell circadian rhythms are regulated by cellular signaling and provide insight as to how clocks may be altered during physiological changes such as regeneration and aging.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.