Evidence map›Paper›PMID 30428359›Full record

ArticleCell reports2018

Microanatomic Distribution of Myeloid Heme Oxygenase-1 Protects against Free Radical-Mediated Immunopathology in Human Tuberculosis.

Krishna C Chinta, Md Aejazur Rahman, Vikram Saini, Joel N Glasgow, Vineel P Reddy, Jeremie M Lever, Shepherd Nhamoyebonde, Alasdair Leslie, Ryan M Wells, Amie Traylor and 10 more

Erratum issuedOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 46 citations in OpenAlex.

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  12. The Role of NRF2 in Mycobacterial Infection.Antioxidants (Basel, Switzerland) · 2021
    Review
  13. Article
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  18. Article
  19. Immune Modulation by Inhibitors of the HO System.International journal of molecular sciences · 2020
    Review
  20. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

20 authors at 4 institutions in 2 countries.

Krishna C ChintaDepartment of Microbiology, School of Medicine, The University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Md Aejazur RahmanAfrica Health Research Institute, Durban 4001, South Africa.
Vikram SainiDepartment of Microbiology, School of Medicine, The University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Joel N GlasgowDepartment of Microbiology, School of Medicine, The University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Vineel P ReddyDepartment of Microbiology, School of Medicine, The University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Jeremie M LeverNephrology Research and Training Center, Division of Nephrology, The University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Shepherd NhamoyebondeAfrica Health Research Institute, Durban 4001, South Africa.
Alasdair LeslieAfrica Health Research Institute, Durban 4001, South Africa.
Ryan M WellsDepartment of Microbiology, School of Medicine, The University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Amie TraylorNephrology Research and Training Center, Division of Nephrology, The University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Rajhmun MadanseinInkosi Albert Luthuli Central Hospital, Durban 4041, South Africa.
Gene P SiegalDepartment of Pathology, The University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Veena B AntonyDivision of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, The University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Jessy DeshaneDivision of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, The University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Gordon WellsAfrica Health Research Institute, Durban 4001, South Africa.
Kievershen NarganAfrica Health Research Institute, Durban 4001, South Africa.
James F GeorgeDivision of Cardiothoracic Surgery, Department of Surgery, The University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Pratistadevi K RamdialDepartment of Anatomical Pathology, NHLS, Inkosi Albert Luthuli Central Hospital, University of KwaZulu-Natal, Durban 4091, South Africa.
Anupam AgarwalNephrology Research and Training Center, Division of Nephrology, The University of Alabama at Birmingham, Birmingham, AL 35294, USA; Department of Veterans Affairs, Birmingham, AL 35294, USA.
Adrie J C SteynDepartment of Microbiology, School of Medicine, The University of Alabama at Birmingham, Birmingham, AL 35294, USA; Africa Health Research Institute, Durban 4001, South Africa; UAB Center for AIDS Research, The University of Alabama at Birmingham, Birmingham, AL 35294, USA; Center for Free Radical Biology, The University of Alabama at Birmingham, Birmingham, AL 35294, USA. Electronic address: asteyn@uab.edu.
University of Alabama at Birmingham · USAfrica Health Research Institute · ZAPediatric Nephrology of Alabama · USUniversity of KwaZulu-Natal · ZA

Funding

Human Heme Oxygenase-1 Gene Regulation in Renal InjuryR01DK059600 · NIDDK · UNIVERSITY OF FLORIDA · PI AGARWAL, ANUPAM, GEORGE, JAMES F · 2002 to 2019
$4.5M
Environmental Cadmium and COPDR01ES029981 · NIEHS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI ANTONY, VEENA B. · 2018 to 2022
$2.5M
Heme oxygenase-1 and the bioenergetic threshold of latent TB and HIV co-infectionR01AI111940 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI STEYN, ADRIE JC · 2015 to 2019
$2.0M
Myeloid Expression of Heme Oxygenase-1 in the AKI to CKD TransitionF31DK115169 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI LEVER, JEREMIE MATTHEW PEABODY · 2017 to 2020
$160k
NIAID NIH HHS R01 AI111940NIDDK NIH HHS F31 DK115169NIDDK NIH HHS R01 DK059600NIEHS NIH HHS R01 ES029981
6 · The paper itself

Abstract

Heme oxygenase-1 (HO-1) is a cytoprotective enzyme that controls inflammatory responses and redox homeostasis; however, its role during pulmonary tuberculosis (TB) remains unclear. Using freshly resected human TB lung tissue, we examined the role of HO-1 within the cellular and pathological spectrum of TB. Flow cytometry and histopathological analysis of human TB lung tissues showed that HO-1 is expressed primarily in myeloid cells and that HO-1 levels in these cells were directly proportional to cytoprotection. HO-1 mitigates TB pathophysiology by diminishing myeloid cell-mediated oxidative damage caused by reactive oxygen and/or nitrogen intermediates, which control granulocytic karyorrhexis to generate a zonal HO-1 response. Using whole-body or myeloid-specific HO-1-deficient mice, we demonstrate that HO-1 is required to control myeloid cell infiltration and inflammation to protect against TB progression. Overall, this study reveals that zonation of HO-1 in myeloid cells modulates free-radical-mediated stress, which regulates human TB immunopathology.

Indexed as

AnimalsArginaseCD4-Positive T-LymphocytesCytokinesFree RadicalsGranulomaHeme Oxygenase-1HumansInflammationLungMice, Inbred C57BLMice, KnockoutMycobacterium tuberculosisMyeloid CellsNeutrophilsNF-E2-Related Factor 2ArginaseCytokinesFree RadicalsHeme Oxygenase-1NFE2L2 protein, humanNF-E2-Related Factor 2Nitric Oxide Synthase Type IIfree radicalheme oxygenase-1histopathological spectrumhuman pulmonary tuberculosishuman TB pathologykaryorrhexismacrophagemycobacterium tuberculosismyeloid cell inflammationneutrophil

Identifiers

PMID30428359
PMCPMC6250977
OpenAlexW2901673493

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.