Evidence map›Paper›PMID 30428350›Full record

ArticleCell reports2018

Circadian Clock Regulation of Hepatic Lipid Metabolism by Modulation of m

Xiang Zhong, Jiayao Yu, Katya Frazier, Xiaocheng Weng, Yi Li, Candace M Cham, Kyle Dolan, Xiaorong Zhu, Nathaniel Hubert, Yun Tao and 8 more

Open access · goldAbstract read
In one paragraph

Article in Cell reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 168 papers.

0numbers the graph read from it
0cells of the map it votes in
168citing papers in PubMed
10.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

168 citing papers in PubMed, 274 citations in OpenAlex.

  1. Article
  2. Review
  3. Dysregulated mScience advances · 2026
    Article
  4. Article
  5. Review
  6. Article
  7. WTAP-Mediated mAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  8. FTO-mediated NR1D1 mScientific reports · 2026
    Article
  9. Co-expression network analysis reveals repression ofbioRxiv : the preprint server for biology · 2026
    Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. The regulatory role of mFrontiers in cell and developmental biology · 2026
    Review
  15. Review
  16. Review
  17. Molecular mechanisms in MASLD/MASH-related HCC.Hepatology (Baltimore, Md.) · 2025
    Review
  18. Review
  19. Article
  20. mCell · 2025
    Article

108 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 3 institutions in 2 countries.

Xiang ZhongCollege of Animal Science and Technology, Nanjing Agricultural University, Jiangsu, Nanjing 210095, PR China; Department of Medicine, University of Chicago, Chicago, IL 60637, USA. Electronic address: zhongxiang@njau.edu.cn.
Jiayao YuCollege of Animal Science and Technology, Nanjing Agricultural University, Jiangsu, Nanjing 210095, PR China.
Katya FrazierDepartment of Medicine, University of Chicago, Chicago, IL 60637, USA.
Xiaocheng WengDepartment of Chemistry, University of Chicago, Chicago, IL 60637, USA; Department of Biochemistry and Molecular Biology, University of Chicago, Chicago, IL 60637, USA; Howard Hughes Medical Institute, University of Chicago, Chicago, IL 60637, USA.
Yi LiCollege of Animal Science and Technology, Nanjing Agricultural University, Jiangsu, Nanjing 210095, PR China.
Candace M ChamDepartment of Medicine, University of Chicago, Chicago, IL 60637, USA.
Kyle DolanDepartment of Medicine, University of Chicago, Chicago, IL 60637, USA.
Xiaorong ZhuDepartment of Medicine, University of Chicago, Chicago, IL 60637, USA.
Nathaniel HubertDepartment of Medicine, University of Chicago, Chicago, IL 60637, USA.
Yun TaoDepartment of Medicine, University of Chicago, Chicago, IL 60637, USA.
Fanfei LinDepartment of Medicine, University of Chicago, Chicago, IL 60637, USA.
Kristina Martinez-GurynDepartment of Medicine, University of Chicago, Chicago, IL 60637, USA.
Yong HuangDepartment of Medicine, University of Chicago, Chicago, IL 60637, USA.
Tian WangCollege of Animal Science and Technology, Nanjing Agricultural University, Jiangsu, Nanjing 210095, PR China.
Jianzhao LiuDepartment of Chemistry, University of Chicago, Chicago, IL 60637, USA; Department of Biochemistry and Molecular Biology, University of Chicago, Chicago, IL 60637, USA; Howard Hughes Medical Institute, University of Chicago, Chicago, IL 60637, USA.
Chuan HeDepartment of Chemistry, University of Chicago, Chicago, IL 60637, USA; Department of Biochemistry and Molecular Biology, University of Chicago, Chicago, IL 60637, USA; Howard Hughes Medical Institute, University of Chicago, Chicago, IL 60637, USA.
Eugene B ChangDepartment of Medicine, University of Chicago, Chicago, IL 60637, USA. Electronic address: echang@medicine.bsd.uchicago.edu.
Vanessa LeoneDepartment of Medicine, University of Chicago, Chicago, IL 60637, USA. Electronic address: vleone@bsd.uchicago.edu.
University of Chicago · USNanjing Agricultural University · CNHoward Hughes Medical Institute · US

Funding

ULTRASTRUCTURE AND CYTOMORPHOLOGY COREP30DK042086 · NIDDK · UNIVERSITY OF CHICAGO · PI ABADIE, VALERIE · 1990 to 2025
$29.8M
Research Training in Digestive Health, Diseases, and NutritionT32DK007074 · NIDDK · UNIVERSITY OF CHICAGO · PI EUGENE B CHANG · 1986 to 2026
$11.3M
Dietary fat effects on gut microbes, host immune state and experimental colitisR01DK097268 · NIDDK · UNIVERSITY OF CHICAGO · PI CHANG, EUGENE B · 2012 to 2016
$2.2M
Diurnal Oscillations in Gut Microbes and Host Immunity in Health and ObesityK01DK111785 · NIDDK · UNIVERSITY OF WISCONSIN-MADISON · PI LEONE, VANESSA ANNE · 2017 to 2021
$723k
NIDDK NIH HHS K01 DK111785NIDDK NIH HHS P30 DK042086NIDDK NIH HHS R01 DK097268NIDDK NIH HHS T32 DK007074
6 · The paper itself

Abstract

Transcriptional regulation of circadian rhythms is essential for lipid metabolic homeostasis, disruptions of which can lead to metabolic diseases. Whether N

Indexed as

AdenosineAnimalsARNTL Transcription FactorsCell ProliferationCircadian ClocksGene DeletionHep G2 CellsHumansLipid MetabolismLiverMethylationMethyltransferasesMice, KnockoutModels, BiologicalPPAR alphaReactive Oxygen SpeciesAdenosineARNTL Transcription FactorsBmal1 protein, mouseMethyltransferasesMettl3 protein, mouseN-methyladenosinePPAR alphaReactive Oxygen SpeciesRNA-Binding ProteinsRNA, MessengerYTHDF2 protein, humanBmal1circadian clockhepaticlipid metabolismm(6)A RNA methylationMETTL3post-transcriptional regulationPPaRαROSYTHDF2

Identifiers

PMID30428350
PMCPMC6532766
OpenAlexW2901106636

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.