ArticlePloS one2018
Uncoupling protein-1 deficiency promotes brown adipose tissue inflammation and ER stress.
Article in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 35 citations in OpenAlex.
- A small‑molecule HDAC/PDE modulator activates human adipocyte UCP1 and resolves inflammatory signaling.Journal of translational medicine · 2026Article
- Purinergic adipocyte-macrophage crosstalk promotes degeneration of thermogenic brown adipose tissue.EMBO reports · 2025Article
- Climate Change, Air Pollution and the Global Obesity Syndemic: a Review of Current Evidence.Current obesity reports · 2025Review
- Relationship between uncoupling protein 1 (UCP1) levels and psoriasis.Turkish journal of medical sciences · 2025Article
- PCPE-1, a brown adipose tissue-derived cytokine, promotes obesity-induced liver fibrosis.The EMBO journal · 2024Article
- Brown fat ATP-citrate lyase links carbohydrate availability to thermogenesis and guards against metabolic stress.Nature metabolism · 2024Article
- Letter-to-the-editor on "A low-carbohydrate diet induces hepatic insulin resistance and metabolic associated fatty liver disease in mice".Molecular metabolism · 2024Article
- Loss of growth differentiation factor 15 exacerbates lung injury in neonatal mice.American journal of physiology. Lung cellular and molecular physiology · 2023Article
- Thermoneutral housing shapes hepatic inflammation and damage in mouse models of non-alcoholic fatty liver disease.Frontiers in immunology · 2023Article
- Insights by which TUDCA is a potential therapy against adiposity.Frontiers in endocrinology · 2023Review
- Thermoneutrality and severe malaria: investigating the effect of warmer environmental temperatures on the inflammatory response and disease progression.Frontiers in immunology · 2023Article
- Browning of the white adipose tissue regulation: new insights into nutritional and metabolic relevance in health and diseases.Nutrition & metabolism · 2022Review
- ADH5-mediated NO bioactivity maintains metabolic homeostasis in brown adipose tissue.Cell reports · 2021Article
- Endoplasmic reticulum stress as the basis of obesity and metabolic diseases: focus on adipose tissue, liver, and pancreas.European journal of nutrition · 2021Review
- The pesticide chlorpyrifos promotes obesity by inhibiting diet-induced thermogenesis in brown adipose tissue.Nature communications · 2021Article
- Differences in [EJNMMI research · 2020Article
- Brown adipose tissue lipoprotein and glucose disposal is not determined by thermogenesis in uncoupling protein 1-deficient mice.Journal of lipid research · 2020Article
- Intrauterine exposure to low-dose DBP in the mice induces obesity in offspring via suppression of UCP1 mediated ER stress.Scientific reports · 2020Article
- Depot-specific UCP1 expression in human white adipose tissue and its association with obesity-related markers.International journal of obesity (2005) · 2020Article
- Thermoneutrality and Immunity: How Does Cold Stress Affect Disease?Frontiers in immunology · 2020Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Inflammation and endoplasmic reticulum (ER) stress are hallmarks of metabolic syndrome. While these metabolic derangements have been well-investigated in white adipose tissue, their existence and etiology in brown adipose tissue (BAT) are poorly understood. Here, we aimed to investigate ER homeostasis and the inflammatory status and of BAT lacking uncoupling protein-1 (UCP1), a protein required for BAT thermogenesis. H&E staining illustrated lipid accumulation and crown-like structures surrounding adipocytes in BAT of UCP1-/- mice housed at room temperature compared to control mice. Further, immunohistological evaluation of F4/80 and gene expression studies demonstrated BAT macrophage infiltration and robust elevation of pro-inflammatory markers in UCP1-/- BAT. ER stress was also present in BAT of UCP1-/- mice, as evidenced by elevated gene expression and post-translational modifications of unfolded protein response components. After four weeks of thermoneutral housing, UCP1-/- mice did not exhibit elevated BAT inflammation and ER stress gene expression compared to WT mice, but depot expansion persisted. Collectively, we demonstrate that the effects of UCP1 deficiency in BAT are not restricted to mitochondrial uncoupling. We conclude that brown adipose tissue of UCP1-/- mice exhibits pro-inflammatory immune cell infiltration and perturbations in ER homeostasis and that this phenotype is driven by cold exposure rather than lipid accumulation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.