Evidence map›Paper›PMID 30427704›Full record

ArticleDNA and cell biology2019

Consumer Antimicrobials on Gut Microbiota and Gut Health.

Haixia Yang, Weicang Wang, Guodong Zhang

Abstract read
In one paragraph

Article in DNA and cell biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Haixia Yang1 Department of Food Science and University of Massachusetts , Amherst, Massachusetts.
Weicang Wang1 Department of Food Science and University of Massachusetts , Amherst, Massachusetts.
Guodong Zhang1 Department of Food Science and University of Massachusetts , Amherst, Massachusetts.
University of Massachusetts Amherst · US

Funding

Prevention of colorectal cancer via targeting CYP epoxygenasesR03CA218520 · NCI · UNIVERSITY OF MASSACHUSETTS AMHERST · PI ZHANG, GUODONG · 2018 to 2019
$147k
NCI NIH HHS R03 CA218520
6 · The paper itself

Abstract

Triclosan (TCS) is a high-volume chemical used as an antimicrobial ingredient in over 2000 consumer products such as toothpastes, cosmetics, and toys. Due to its widespread use, it causes ubiquitous contamination in the environment and is frequently detected in the human body, raising concerns about its impact on environmental pollution and human health. Our recent study showed that short-time exposure to low-dose TCS causes colonic inflammation, increases severity of colitis, and exacerbates colitis-associated colon tumorigenesis in mice, through gut microbiota- and Toll-like receptor 4 (TLR4)-dependent mechanisms. In addition, we demonstrate that beyond TCS, other antimicrobial chemicals used in consumer products also exaggerate colitis and colon cancer in mice. Together, these results highlight the importance to further evaluate these consumer antimicrobials on gut health, to develop potential further regulatory policies.

Indexed as

AnimalsAnti-Infective AgentsCarcinogenesisColitisColonGastrointestinal MicrobiomeHumansMiceTriclosanAnti-Infective AgentsTriclosancolon cancercolon inflammationgut microbiotatriclosan

Identifiers

PMID30427704
PMCPMC6350052
OpenAlexW2901376653

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.