Evidence map›Paper›PMID 30427219›Full record

ArticleAmerican journal of physiology. Renal physiology2019

Role of PKC and AMPK in hypertonicity-stimulated water reabsorption in rat inner medullary collecting ducts.

Josephine K Liwang, Joseph A Ruiz, Lauren M LaRocque, Fitra Rianto, Fuying Ma, Yanhua Wang

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of physiology. Renal physiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. PKA-independent vasopressin signaling in renal collecting duct.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Josephine K LiwangDivision of Renal Medicine, Department of Medicine, Emory University , Atlanta, Georgia.
Joseph A RuizDivision of Renal Medicine, Department of Medicine, Emory University , Atlanta, Georgia.
Lauren M LaRocqueDivision of Renal Medicine, Department of Medicine, Emory University , Atlanta, Georgia.
Fitra RiantoDivision of Renal Medicine, Department of Medicine, Emory University , Atlanta, Georgia.
Fuying MaDivision of Renal Medicine, Department of Medicine, Emory University , Atlanta, Georgia.
Yanhua WangDivision of Renal Medicine, Department of Medicine, Emory University , Atlanta, Georgia.
Emory University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hypertonicity increases water permeability, independently of vasopressin, in the inner medullary collecting duct (IMCD) by increasing aquaporin-2 (AQP2) membrane accumulation. We investigated whether protein kinase C (PKC) and adenosine monophosphate kinase (AMPK) are involved in hypertonicity-regulated water permeability. Increasing perfusate osmolality from 150 to 290 mosmol/kgH

Indexed as

AMP-Activated Protein KinasesAnimalsAquaporin 2Body WaterEndocytosisFemaleKidney Tubules, CollectingMaleOsmolar ConcentrationOsmoregulationPermeabilityPhosphorylationProtein Kinase CRatsRenal ReabsorptionSaline Solution, HypertonicAMP-Activated Protein KinasesAqp2 protein, ratAquaporin 2Protein Kinase CSaline Solution, HypertonicAMPKhypertonicitynephrogenic diabetes insipidusPKCwater transport

Identifiers

PMID30427219
PMCPMC6397368
OpenAlexW2901831456

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.