Evidence map›Paper›PMID 30427188›Full record

ArticleMolecular pharmaceutics2019

Labeling Single Domain Antibody Fragments with Fluorine-18 Using 2,3,5,6-Tetrafluorophenyl 6-[

Zhengyuan Zhou, Darryl McDougald, Nick Devoogdt, Michael R Zalutsky, Ganesan Vaidyanathan

Abstract read
In one paragraph

Article in Molecular pharmaceutics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 33 citations in OpenAlex.

  1. Article
  2. A novelEJNMMI radiopharmacy and chemistry · 2026
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  6. Radiosynthesis and preclinical evaluations of [American journal of nuclear medicine and molecular imaging · 2024
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  9. Review
  10. Evaluation of anScientific reports · 2022
    Article
  11. Site-Specific and Residualizing Linker forJournal of nuclear medicine : official publication, Society of Nuclear Medicine · 2021
    Article
  12. Review
  13. Review
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  16. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Zhengyuan ZhouDepartment of Radiology , Duke University Medical Center , Durham , North Carolina 27710 , United States.
Darryl McDougaldDepartment of Radiology , Duke University Medical Center , Durham , North Carolina 27710 , United States.
Nick DevoogdtIn vivo Cellular and Molecular Imaging laboratory , Vrije Universiteit Brussel, (VUB) , 1090 , Brussels , Belgium.
Michael R ZalutskyDepartment of Radiology , Duke University Medical Center , Durham , North Carolina 27710 , United States.
Ganesan VaidyanathanDepartment of Radiology , Duke University Medical Center , Durham , North Carolina 27710 , United States.ORCID 0000-0003-3041-8275
Duke Medical Center · USVrije Universiteit Brussel · BE

Funding

RADIOTHERAPY USING MONOCLONAL ANTIBODIES AND ASTATINER01CA042324 · NCI · DUKE UNIVERSITY · PI ZALUTSKY, MICHAEL ROD · 1985 to 2020
$4.6M
ASTATINE AND IODINE RADIOLABELED MONOCLONAL ANTIBODIESR37CA042324 · NCI · DUKE UNIVERSITY · PI ZALUTSKY, MICHAEL ROD · 1999 to 2008
$3.8M
Labeling nanobodies with 18F residualizing labels for HER2 specific PET imagingR01CA188177 · NCI · DUKE UNIVERSITY · PI VAIDYANATHAN, GANESAN · 2015 to 2019
$1.8M
NCI NIH HHS R01 CA042324NCI NIH HHS R01 CA188177NCI NIH HHS R37 CA042324
6 · The paper itself

Abstract

ImmunoPET agents are being investigated to assess the status of epidermal growth factor receptor 2 (HER2) in breast cancer patients with the goal of selecting those likely to benefit from HER2-targeted therapies and monitoring their progress after these treatments. We have been exploring the use of single domain antibody fragments (sdAbs) labeled with

Indexed as

AnimalsApoptosisBenzoatesBlotting, WesternBreast NeoplasmsCell Cycle CheckpointsCell Line, TumorCytochromes cDNA FragmentationErb-b2 Receptor Tyrosine KinasesFemaleFlow CytometryFluorine RadioisotopesHumansIodine RadioisotopesKidneyBenzoatesCytochromes cErb-b2 Receptor Tyrosine KinasesFluorine-18Fluorine RadioisotopesIodine RadioisotopesN-succinimidyl-4-fluorobenzoateRadiopharmaceuticalsSingle-Domain AntibodiesSuccinimides2,3,5,6-etrafluorophenyl 6-fluoronicotinatefluorine-18HER2immunoPETN-succinimidyl 4-fluorobenzoatesingle domain antibody fragment

Identifiers

PMID30427188
PMCPMC6465114
OpenAlexW2901028592

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.