Evidence map›Paper›PMID 30426851›Full record

ArticleTissue engineering. Part A2019

The Effect of Laminin-111 Hydrogels on Muscle Regeneration in a Murine Model of Injury.

Madison Marcinczyk, Andrew Dunn, Gabriel Haas, Josh Madsen, Robert Scheidt, Krishna Patel, Muhamed Talovic, Koyal Garg

Abstract read
In one paragraph

Article in Tissue engineering. Part A, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
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  6. Article
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  8. Article
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  10. Article
  11. Review
  12. Article
  13. Next Stage Approach to Tissue Engineering Skeletal Muscle.Bioengineering (Basel, Switzerland) · 2020
    Review
  14. Review
  15. Biomimetic Scaffolds in Skeletal Muscle Regeneration.Discoveries (Craiova, Romania) · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Madison MarcinczykDepartment of Biomedical Engineering, Parks College of Engineering, Aviation, and Technology, St. Louis, Missouri.
Andrew DunnDepartment of Biomedical Engineering, Parks College of Engineering, Aviation, and Technology, St. Louis, Missouri.
Gabriel HaasDepartment of Biomedical Engineering, Parks College of Engineering, Aviation, and Technology, St. Louis, Missouri.
Josh MadsenDepartment of Biomedical Engineering, Parks College of Engineering, Aviation, and Technology, St. Louis, Missouri.
Robert ScheidtDepartment of Biomedical Engineering, Parks College of Engineering, Aviation, and Technology, St. Louis, Missouri.
Krishna PatelDepartment of Biomedical Engineering, Parks College of Engineering, Aviation, and Technology, St. Louis, Missouri.
Muhamed TalovicDepartment of Biomedical Engineering, Parks College of Engineering, Aviation, and Technology, St. Louis, Missouri.
Koyal GargDepartment of Biomedical Engineering, Parks College of Engineering, Aviation, and Technology, St. Louis, Missouri.

Funding

Resource Based Center for Musculoskeletal Biology and Medicine (Overall Application)P30AR074992 · NIAMS · WASHINGTON UNIVERSITY · PI MATTHEW J SILVA · 2019 to 2026
$6.8M
NIAMS NIH HHS P30 AR074992
6 · The paper itself

Abstract

impact statementExtremity injuries make up the most common survivable injuries in vehicular accidents and modern military conflicts. A majority of these injuries involve volumetric muscle loss (VML). The potential for donor site morbidity may limit the clinical use of autologous muscle grafts for VML injuries. Treatments that can improve the regeneration of functional muscle tissue are critically needed to improve limb salvage and reduce the rate of delayed amputations. The development of a laminin-111-enriched fibrin hydrogel will offer a potentially transformative and "off-the-shelf" clinically relevant therapy for functional skeletal muscle regeneration.

Indexed as

AnimalsDisease Models, AnimalHydrogelsLamininMaleMice, Inbred C57BLMuscle ProteinsMuscle, SkeletalOrgan SizeRegenerationHydrogelsLamininMuscle Proteinshydrogelslaminin-111volumetric muscle loss

Identifiers

PMID30426851
PMCPMC9839345

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.