ArticlePediatric blood & cancer2019
Using the Patient-Reported Outcomes Measurement Information System (PROMIS) to measure symptom burden reported by patients with brain tumors.
Article in Pediatric blood & cancer, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 48 citations in OpenAlex.
- A critical evaluation of the content validity of patient-reported outcome measures assessing health-related quality of life in children with cancer: a systematic review.Journal of patient-reported outcomes · 2023Pooled it
- Severe fatigue after treatment for childhood cancer.The Cochrane database of systematic reviews · 2020Pooled it
- Effect of Narrative Nursing Intervention Based on Targeted Nursing Intervention on Anxiety and Nursing Satisfaction of Patients with Malignant Tumors Undergoing Chemotherapy.Journal of healthcare engineering · 2021Trial
- Design and rationale of the MIGHTEE study: Motivational interviewing and group heart transplant exercise and education.JHLT open · 2026Article
- Biopsychosocial risk factors for pain in early phases of pediatric cancer treatment.Frontiers in psychology · 2025Article
- Physical Health-Related Quality of Life and Postsurgical Outcomes in Brain Tumor Resection Patients.Asian journal of neurosurgery · 2024Article
- Preoperative patient-reported physical health-related quality of life predicts short-term postoperative outcomes in brain tumor patients.Journal of neuro-oncology · 2024Article
- A Survey of Patient-Relevant Outcomes in Pediatric Craniopharyngioma: Focus on Hypothalamic Obesity.Frontiers in endocrinology · 2022Article
- Measuring Self-Reported Cancer-Related Cognitive Impairment: Recommendations From the Cancer Neuroscience Initiative Working Group.Journal of the National Cancer Institute · 2021Article
- Validity and reliability of the French version of the Pediatric Quality of Life Inventory™ brain tumor module.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2021Article
- Considerations to Support Use of Patient-Reported Outcomes Measurement Information System Pediatric Measures in Ambulatory Clinics.The Journal of pediatrics · 2021Article
- Article
- Expanding construct validity of established and new PROMIS Pediatric measures for children and adolescents receiving cancer treatment.Pediatric blood & cancer · 2020Article
- Pediatric Palliative Care in Oncology.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2020Review
- Advances in pediatric psychooncology.Current opinion in pediatrics · 2020Review
- Optimizing symptom control in children and adolescents with cancer.Pediatric research · 2019Review
Corrections and comments
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Authors and funding
9 authors at 6 institutions in 1 country.
Funding
Abstract
backgroundChildren with brain tumors can experience symptom burden throughout their disease continuum. The aim of the study was to evaluate symptom burden reported by children with brain tumors and factors that potentially were associated with their symptoms.
methodsData from 199 children with brain tumors aged 7-22 (mean age = 14 years; 52% males; 76% white) were analyzed. Symptom burden was assessed using the Patient-Reported Outcomes Measurement Information System (PROMIS) via computerized adaptive testing (CAT)-anxiety, depression, fatigue, mobility, upper extremity function, peer relationship, and cognition. Patients and parents completed Symptom Distress Scales (SDS). Test statistics and ANOVA were used to evaluate relationships between PROMIS measures and potentially influential variables.
resultsSignificant results (P < 0.01) showing impact of symptom burden included: PROMIS measures correlated with SDSs reported by patients and parents on all comparisons. Fatigue, mobility, and upper extremity function were associated with Karnofsky functional performance status, number of treatment modalities (0-3), and time since last treatment (≤1 year, >1 year). Fatigue and cognition were associated with educational program (regular classroom without an individualized education plan vs those that had an individualized education plan); mobility and upper extremity function were associated with time since last radiation. Mobility, upper extremity function, and anxiety were associated with time since last chemotherapy.
conclusionsSignificant associations were found between PROMIS and SDS as well as clinical and demographic characteristics. Brief-yet-precise PROMIS CATs can be used to systematically assess symptom burden experienced by children with brain tumors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.