ArticleTraffic (Copenhagen, Denmark)2019
Rab-mediated trafficking in the secondary cells of Drosophila male accessory glands and its role in fecundity.
Article in Traffic (Copenhagen, Denmark), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Membrane lipid composition and rapid endocytic retrieval modulate Wingless secretion.The EMBO journal · 2026Article
- Abdominal-B regulates the male seminal fluid transferome and new fecundity factors required for sperm sex peptide binding.PLoS genetics · 2026Article
- Characterization of the post-mating responses of Drosophila hydei, a species that lacks Sex-Peptide.Communications biology · 2026Article
- Rab4 spatially and functionally converges with Rab7 in the degradative endolysosomal network.Molecular biology of the cell · 2026Article
- Amyloid-β disrupts APP-regulated protein aggregation and dissociation from recycling endosomal membranes.The EMBO journal · 2025Article
- Upstream open reading frames repress the translation from the iab-8 RNA.PLoS genetics · 2024Article
- Cell cycle variants during Drosophila male accessory gland development.G3 (Bethesda, Md.) · 2024Article
- Impairment of the Glial Phagolysosomal System Drives Prion-Like Propagation in aThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Impairment of the glial phagolysosomal system drives prion-like propagation in abioRxiv : the preprint server for biology · 2024Article
- A Rab6 to Rab11 transition is required for dense-core granule and exosome biogenesis in Drosophila secondary cells.PLoS genetics · 2023Article
- Accessory ESCRT-III proteins are conserved and selective regulators of Rab11a-exosome formation.Journal of extracellular vesicles · 2023Article
- Recovery from heat-induced infertility-A study of reproductive tissue responses and fitness consequences in maleEcology and evolution · 2022Article
- Male-female communication enhances release of extracellular vesicles leading to high fertility in Drosophila.Communications biology · 2022Article
- Single-nucleus transcriptomes reveal evolutionary and functional properties of cell types in the Drosophila accessory gland.Genetics · 2022Article
- Identification of a micropeptide and multiple secondary cell genes that modulateProceedings of the National Academy of Sciences of the United States of America · 2021Article
- Glutamine deprivation alters the origin and function of cancer cell exosomes.The EMBO journal · 2020Article
- Extracellular vesicles: eat glutamine and spit acidic bubbles.The EMBO journal · 2020Article
- Rab-mediated trafficking in the secondary cells of Drosophila male accessory glands and its role in fecundity.Traffic (Copenhagen, Denmark) · 2019Article
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8 authors.
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Abstract
The male seminal fluid contains factors that affect female post-mating behavior and physiology. In Drosophila, most of these factors are secreted by the two epithelial cell types that make up the male accessory gland: the main and secondary cells. Although secondary cells represent only ~4% of the cells of the accessory gland, their contribution to the male seminal fluid is essential for sustaining the female post-mating response. To better understand the function of the secondary cells, we investigated their molecular organization, particularly with respect to the intracellular membrane transport machinery. We determined that large vacuole-like structures found in the secondary cells are trafficking hubs labeled by Rab6, 7, 11 and 19. Furthermore, these organelles require Rab6 for their formation and many are essential in the process of creating the long-term postmating behavior of females. In order to better serve the intracellular membrane and protein trafficking communities, we have created a searchable, online, open-access imaging resource to display our complete findings regarding Rab localization in the accessory gland.
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