ArticleCancer science2019
T cell receptor β-chain repertoire analysis of tumor-infiltrating lymphocytes in pancreatic cancer.
Article in Cancer science, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 17 citations in OpenAlex.
- Liver transplant-facilitated CD161Nature communications · 2025Article
- Combination of oligo-fractionated irradiation with nivolumab can induce immune modulation in gastric cancer.Journal for immunotherapy of cancer · 2024Article
- T-cell repertoire diversity: friend or foe for protective antitumor response?Journal of experimental & clinical cancer research : CR · 2022Review
- Evaluation of the TCR Repertoire as a Predictive and Prognostic Biomarker in Cancer: Diversity or Clonality?Cancers · 2022Review
- Immune Microenvironment Characteristics of Urachal Carcinoma and Its Implications for Prognosis and Immunotherapy.Cancers · 2022Article
- Intratumor heterogeneity: the hidden barrier to immunotherapy against MSI tumors from the perspective of IFN-γ signaling and tumor-infiltrating lymphocytes.Journal of hematology & oncology · 2021Review
- Analysis of T-cell receptor repertoire in peripheral blood of patients with pancreatic cancer and other pancreatic diseases.Journal of cellular and molecular medicine · 2021Article
- UXT antisense RNA 1 sever as a novel prognostic long non-coding RNA in early stage pancreatic ductal adenocarcinoma patients after receiving pancreaticoduodenectomy.Journal of Cancer · 2021Article
- Tumor-Infiltrating B- and T-Cell Repertoire in Pancreatic Cancer Associated With Host and Tumor Features.Frontiers in immunology · 2021Article
- Liquid biopsy and tumor heterogeneity in metastatic solid tumors: the potentiality of blood samples.Journal of experimental & clinical cancer research : CR · 2020Review
- Measuring Intratumoral Heterogeneity of Immune Repertoires.Frontiers in oncology · 2020Article
- Comprehensive immune characterization and T-cell receptor repertoire heterogeneity of retroperitoneal liposarcoma.Cancer science · 2019Article
- Spatial heterogeneity of the T cell receptor repertoire reflects the mutational landscape in lung cancer.Nature medicine · 2019Article
- A PD-L2-based immune marker signature helps to predict survival in resected pancreatic ductal adenocarcinoma.Journal for immunotherapy of cancer · 2019Article
- T cell receptor β-chain repertoire analysis of tumor-infiltrating lymphocytes in pancreatic cancer.Cancer science · 2019Article
Corrections and comments
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Authors and funding
10 authors at 1 institution in 2 countries.
Funding
Abstract
Pancreatic cancer is lethal due to lack of perceptible symptoms and effective treatment methods. Immunotherapy may provide promising therapeutic choices for malignant tumors like pancreatic cancer. Tumor-infiltrating lymphocytes (TIL) in tumor mesenchyme could recognize peptide antigens presented on the surface of tumor cells. The present study aimed to test the relationship between the T cell receptor (TCR) β repertoire of the tumor and peripheral blood, and also to investigate the intra-tumor spatial heterogeneity of the TCR β repertoire in pancreatic cancer. To the best of our knowledge, this is the first study to evaluate the clonal composition of TCR β repertoire in TIL across the spatial extent of pancreatic cancer. In this study, we studied 5 patients who were diagnosed with primary pancreatic cancer. Ultra-deep sequencing was used to assess the rearrangement of the TCR β-chain (TCR β) gene. HE staining and immunohistochemistry of CD3, CD4, CD8 and HLA class I were used to show histopathology and immune conditions macroscopically. TIL repertoire showed that different regions of the same tumor showed a greater number of repertoire overlaps between each other than between peripheral blood, which suggested that T cell clones in pancreatic cancer might be quite different from those in peripheral blood. In contrast, intra-tumoral TCR β repertoires were spatially homogeneous between different regions of a single tumor tissue. Based on these results, we speculated that the cellular adaptive immune response in pancreatic cancer was spatially homogeneous; this may pave the way for immunotherapy for the treatment of pancreatic cancer patients.
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