Evidence map›Paper›PMID 30426385›Full record

ArticleMolecular biology reports2019

Cytotoxic and cell cycle arrest induction of pentacyclic triterpenoides separated from Lantana camara leaves against MCF-7 cell line in vitro.

Zahraa R Shamsee, Ali Z Al-Saffar, Ahmed F Al-Shanon, Jameel R Al-Obaidi

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Article in Molecular biology reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Review
  2. Article
  3. Characterization of soil-derived Bacillus subtilis metabolites against breast cancer: In vitro and in silico studies.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2025
    Article
  4. Review
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Zahraa R ShamseeDepartment of Molecular and Medical Biotechnology, College of Biotechnology, Al-Nahrain University, Baghdad, Iraq.
Ali Z Al-SaffarDepartment of Molecular and Medical Biotechnology, College of Biotechnology, Al-Nahrain University, Baghdad, Iraq. ali_btc@biotech.nahrainuniv.edu.iq.
Ahmed F Al-ShanonBiotechnology Research Center, Al-Nahrain University, Baghdad, Iraq.
Jameel R Al-ObaidiAgro-Biotechnology Institute Malaysia (ABI), C/O MARDI Headquarters, 43400, Serdang, Selangor, Malaysia. jr_alobaidi@yahoo.com.ORCID http://orcid.org/0000-0002-5705-0223

Funding

Al-Nahrain University Grant No. COB-85
6 · The paper itself

Abstract

Lantana camara is an important medicinal plant that contains many active compounds, including pentacyclic triterpenoids, with numerous biological activities. The present study was conducted to evaluate the anti-oxidant, anti-tumour, and cell cycle arrest properties of chemical compounds extracted from L. camara leaves. Four compounds were identified after subjecting the plant methanolic extract to LC-MS/MS analysis: lantadene A, lantadene B, icterogenin, and lantadene C. Potential antioxidant activity was examined using 2, 2-diphenyl-1-picrylhydrazyl and compared with vitamin C as a control. Lantadene A and B were confirmed to possess the highest scavenging activity, while icterogenin and lantadene C exhibited a lesser antioxidant effect. All extracted compounds exerted a dose-dependent reduction in MCF-7 cell viability; however, lantadene B showed the highest anti-cancer activity, with an IC

Indexed as

AntioxidantsCell Cycle CheckpointsChromatography, LiquidHumansLantanaMCF-7 CellsOleanolic AcidPentacyclic TriterpenesPlant ExtractsPlant LeavesTandem Mass SpectrometryTriterpenesAntioxidantsicterogeninlantadene Blantadene COleanolic AcidPentacyclic TriterpenesPlant Extractsrehmannic acidTriterpenesCell cycleLantadeneLantana camaraMCF-7Plant antioxidants

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What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.