ArticleCell biology and toxicology2019
The insect, Galleria mellonella, is a compatible model for evaluating the toxicology of okadaic acid.
Article in Cell biology and toxicology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 60 citations in OpenAlex.
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- Insights into the pathophysiological, molecular, and ultrastructural alterations induced by cadmium oxide nanoparticle toxicity in the midgut of Galleria mellonella.Scientific reports · 2025Article
- Galleria mellonella possesses the essential nutritional needs to host the fastidious Huanglongbing bacterial pathogen 'Candidatus Liberibacter asiaticus'.Communications biology · 2025Article
- Oxidative, Genotoxic and Epigenotoxic Effects of Pimpla turionellae Venom at Pharmacological Perspective.Neotropical entomology · 2025Article
- Galleria mellonella as a drug discovery model to study oxidative stress.Scientific reports · 2025Article
- Impacts of CombiningInsects · 2024Article
- Insights into the biocompatibility of biodegradable metallic molybdenum for cardiovascular applications-a critical review.Frontiers in bioengineering and biotechnology · 2024Review
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- In Vitro and In Vivo Biocompatibility of Natural and SyntheticInternational journal of molecular sciences · 2023Article
- Lepidopteran insects: emerging model organisms to study infection by enteropathogens.Folia microbiologica · 2023Review
- A Review of In Situ Methods-Solid Phase Adsorption Toxin Tracking (SPATT) and Polar Organic Chemical Integrative Sampler (POCIS) for the Collection and Concentration of Marine Biotoxins and Pharmaceuticals in Environmental Waters.Molecules (Basel, Switzerland) · 2022Review
- Insect Models in Nutrition Research.Biomolecules · 2022Review
- Antimicrobial Efficacy of Green Synthesized Nanosilver with Entrapped Cinnamaldehyde against Multi-Drug-Resistant EnteroaggregativePharmaceutics · 2022Article
- Octanoic Acid-An Insecticidal Metabolite ofInternational journal of molecular sciences · 2022Article
- Inhibiting DHN- and DOPA-melanin biosynthesis pathway increased the therapeutic value of itraconazole in Madurella mycetomatis infected Galleria mellonella.Medical mycology · 2022Article
- The Spread of Antibiotic Resistance Genes In Vivo Model.The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale · 2022Review
- Differential immune responses in new and old fruit fly-parasitoid associations: Implications for their management.Frontiers in physiology · 2022Article
- The diarrhetic shellfish-poisoning toxin, okadaic acid, provokes gastropathy, dysbiosis and susceptibility to bacterial infection in a non-rodent bioassay, Galleria mellonella.Archives of toxicology · 2021Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The polyether toxin, okadaic acid, causes diarrhetic shellfish poisoning in humans. Despite extensive research into its cellular targets using rodent models, we know little about its putative effect(s) on innate immunity. We inoculated larvae of the greater wax moth, Galleria mellonella, with physiologically relevant doses of okadaic acid by direct injection into the haemocoel (body cavity) and/or gavage (force-feeding). We monitored larval survival and employed a range of cellular and biochemical assays to assess the potential harmful effects of okadaic acid. Okadaic acid at concentrations ≥ 75 ng/larva (≥ 242 μg/kg) led to significant reductions in larval survival (> 65%) and circulating haemocyte (blood cell) numbers (> 50%) within 24 h post-inoculation. In the haemolymph, okadaic acid reduced haemocyte viability and increased phenoloxidase activities. In the midgut, okadaic acid induced oxidative damage as determined by increases in superoxide dismutase activity and levels of malondialdehyde (i.e. lipid peroxidation). Our observations of insect larvae correspond broadly to data published using rodent models of shellfish-poisoning toxidrome, including complementary LD
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